公开(公告)号：US11691971B2

公开(公告)日：2023-07-04

申请号：US17350470

申请日：2021-06-17

申请人： Incyte Corporation

发明人： Stacey Shepard ,  Lixin Shao ,  Liangxing Wu ,  Wenqing Yao

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present application provides naphthyridinone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：US11046658B2

公开(公告)日：2021-06-29

申请号：US16458530

申请日：2019-07-01

申请人： Incyte Corporation

发明人： Brent Douty ,  Yanran Ai ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Eddy W. Yue ,  Andrew W. Buesking

IPC分类号： C07D241/20 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D471/06 ,  C07D487/04

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US10442803B2

公开(公告)日：2019-10-15

申请号：US15688313

申请日：2017-08-28

申请人： Incyte Corporation

发明人： James D. Rodgers ,  Stacey Shepard ,  Haisheng Wang ,  Lixin Shao

IPC分类号： C07D471/14 ,  A61K31/437

摘要： The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

公开(公告)号：US10065963B2

公开(公告)日：2018-09-04

申请号：US15343375

申请日：2016-11-04

申请人： Incyte Corporation

发明人： Artem Shvartsbart ,  Stacey Shepard ,  Andrew P. Combs ,  Lixin Shao ,  Nikoo Falahatpisheh ,  Ge Zou ,  Eddy W. Yue ,  Ravi Kumar Jalluri

IPC分类号： C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  A61P35/00 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20170129899A1

公开(公告)日：2017-05-11

申请号：US15343375

申请日：2016-11-04

申请人： Incyte Corporation

发明人： Artem Shvartsbart ,  Stacey Shepard ,  Andrew P. Combs ,  Lixin Shao ,  Nikoo Falahatpisheh ,  Ge Zou ,  Andrew W. Buesking ,  Richard B. Sparks ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US09334274B2

公开(公告)日：2016-05-10

申请号：US14250843

申请日：2014-04-11

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： James D Rodgers ,  Stacey Shepard ,  Argyrios G Arvanitis ,  Haisheng Wang ,  Louis Storace ,  Beverly Folmer ,  Wenyu Zhu ,  Joseph Glenn ,  Lixin Shao

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D487/04 ,  C07D519/00 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

摘要： The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

摘要翻译： 本发明涉及式I的N-（杂）芳基 - 吡咯烷衍生物：其是JAK抑制剂，例如选择性JAK1抑制剂，其可用于治疗JAK相关疾病，包括例如炎性和自身免疫性疾病，以及 作为癌症。

公开(公告)号：US09309246B2

公开(公告)日：2016-04-12

申请号：US14575284

申请日：2014-12-18

申请人： Incyte Corporation

发明人： James D. Rodgers ,  Stacey Shepard ,  Haisheng Wang ,  Lixin Shao

IPC分类号： C07D471/14

CPC分类号： C07D471/14 ,  A61K31/437

摘要： The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

摘要翻译： 本发明涉及作为BET蛋白如BRD2，BRD4，BRD4和BRD-t的抑制剂的三环杂环，可用于治疗诸如癌症的疾病。

公开(公告)号：US20240228498A1

公开(公告)日：2024-07-11

申请号：US18430528

申请日：2024-02-01

申请人： Incyte Corporation

发明人： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61P25/28 ,  A61P35/00 ,  C07B2200/07 ,  C07B2200/13

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20220251087A1

公开(公告)日：2022-08-11

申请号：US17183253

申请日：2021-02-23

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Stacey Shepard ,  Eddy W. Yue ,  Artem Shvartsbart ,  David M. Burns ,  Daniel Levy

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20220213107A1

公开(公告)日：2022-07-07

申请号：US17537674

申请日：2021-11-30

申请人： Incyte Corporation

发明人： Brent Douty ,  Andrew W. Buesking ,  David M. Burns ,  Andrew P. Combs ,  Nikoo Falahatpisheh ,  Ravi Kumar Jalluri ,  Daniel Levy ,  Padmaja Polam ,  Lixin Shao ,  Stacey Shepard ,  Artem Shvartsbart ,  Richard B. Sparks ,  Eddy W. Yue

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P25/28

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.