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公开(公告)号：US20170153164A1
公开(公告)日：2017-06-01
申请号：US15431655
申请日：2017-02-13
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/10 , G01N1/14 , G01N1/34 , G01N1/4077 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
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12.发明授权Liquid to liquid biological particle concentrator with disposable fluid path 有权液体与液体生物颗粒浓缩器与一次性流体路径公开(公告)号：US09574977B2
公开(公告)日：2017-02-21
申请号：US14191205
申请日：2014-02-26
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/10 , G01N1/14 , G01N1/34 , G01N1/4077 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 一次性吸头包括用于吸取样品并连接到浓缩单元的流体端口。
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公开(公告)号：US20160302776A1
公开(公告)日：2016-10-20
申请号：US15132046
申请日：2016-04-18
Applicant: InnovaPrep LLC
Inventor： Alec D. Adolphson , Ann K. Packingham , Andrew E. Page , David S. Alburty , Zachary A. Packingham , John D. Birkenholz , Michael F. Fischer
CPC classification number: A61B10/02 , A61B10/0096 , A61B2010/0216
Abstract: Devices, systems and methods are disclosed which relate to using wet foam elution for removal of particles from swabs and wipes. This allow users to capture particles from surfaces and recover them by elution into small sample volumes for subsequent detection for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. More specifically, the swabs or wipes are used to collect samples in the standard ways that commercially available swabs and wipes are in use today; from, for instance, food preparation surfaces in food plants, from production equipment in pharmaceutical facilities, for collection of dry powders during bioterrorism event response, and for collection of clinical samples such as nasal, throat, nasopharyngeal, and wounds.
Abstract translation: 公开了涉及使用湿泡沫洗脱来从拭子和擦拭物去除颗粒的装置，系统和方法。 这允许用户从表面捕获颗粒，并通过洗脱到小样本体积中进行回收，以便随后检测人类临床，兽医，食品安全，制药，疫情调查，取证，生物识别和生物恐怖反应，环境监测和其他应用，其中收集 需要表面和人体或动物的样品。 更具体地，拭子或擦拭物用于以目前市售的拭子和擦拭巾的标准方式收集样品; 例如食品工厂中的食物制备表面，制药设备中的生产设备，用于在生物恐怖事件应答期间收集干粉，以及用于收集诸如鼻，喉，鼻咽和伤口的临床样品。
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14.发明申请Devices, Systems and Methods for Elution of Particles from Flat Filters 审中-公开用于从扁平过滤器中洗脱颗粒的装置，系统和方法公开(公告)号：US20140076071A1
公开(公告)日：2014-03-20
申请号：US14084403
申请日：2013-11-19
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
IPC: G01N1/22
CPC classification number: G01N1/4077 , B01D46/0032 , B01D46/0067 , B01D46/543 , G01N1/2205 , G01N1/2273 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
Abstract translation: 公开了涉及使用湿泡沫洗脱法从扁平过滤器去除颗粒的装置，系统和方法。 颗粒从大气中捕获到扁平过滤器上。 然后将扁平过滤器放入提取器中，该提取器将湿泡沫流通过扁平过滤器。 泡沫的膨胀用于有效去除捕获的颗粒。 泡沫从捕获的颗粒与过滤器一起流入样品容器。 一旦在样品容器中，泡沫快速分解，留下分析就绪的液体样品。
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公开(公告)号：US12050162B2
公开(公告)日：2024-07-30
申请号：US17726625
申请日：2022-04-22
Applicant: INNOVAPREP LLC
Inventor： Alec D. Adolphson , Andrew E. Page , John D. Birkenholz , David Goad
CPC classification number: G01N1/34 , B01L3/502753 , B01L2300/0681 , B01L2300/0832 , B01L2400/0683
Abstract: Devices, systems and methods are disclosed which relate to a prefiltration device that can be used with the concentrating pipette instruments and other devices which draw a sample in through one opening and dispense a concentrated or eluted sample out through the same opening. The device allows the sample to be passed through a prefilter when entering the opening and then bypassed the prefilter when being dispensed through the same opening.
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Patent Agency Ranking
公开(公告)号：US11747238B2
公开(公告)日：2023-09-05
申请号：US17209434
申请日：2021-03-23
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/10 , G01N1/14 , G01N1/34 , G01N1/4077 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
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公开(公告)号：US20220125333A1
公开(公告)日：2022-04-28
申请号：US17511487
申请日：2021-10-26
Applicant: INNOVAPREP LLC
Inventor： David S. Alburty , Andew E. Page , John D. Birkenholz , Kathleen Ruegsegger , Ann K. Packingham , Zachary A. Packingham , Alec D. Adolphson , Pamela S. Murowchick , Hugh Olsen , Bryan C. Long , Steven D. Graham
Abstract: Devices and methods are described for using normal human breath to separately capture particles from inhaled and exhaled breath for analysis. This device can be constructed as a wearable device worn as a mask with separately removable filters on the inside and the outside of an efficient collection material.
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18.发明授权Liquid to liquid biological particle concentrator with disposable fluid path 有权液体与液体生物颗粒浓缩器与一次性流体路径公开(公告)号：US09593359B2
公开(公告)日：2017-03-14
申请号：US14084385
申请日：2013-11-19
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/4077 , B01L3/0275 , B01L2200/026 , B01L2200/0631 , B01L2300/0681 , B01L2300/161 , C12Q1/24 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.
Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 将一次性尖端附接到仪器的所有导管组合成尖端上端的单个连接点。
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公开(公告)号：US12055469B2
公开(公告)日：2024-08-06
申请号：US18205494
申请日：2023-06-02
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
CPC classification number: G01N1/4077 , B01D46/0032 , B01D46/543 , B01D46/70 , G01N1/2205 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
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公开(公告)号：US11986168B2
公开(公告)日：2024-05-21
申请号：US17103912
申请日：2020-11-24
Applicant: InnovaPrep LLC
Inventor： Alec D. Adolphson , Ann K. Packingham , Andrew E. Page , David S. Alburty , Zachary A. Packingham , John D. Birkenholz , Michael F. Fischer
CPC classification number: A61B10/02 , A61B10/0096 , A61B2010/0216 , B01L3/5029 , G01N2001/028
Abstract: Devices, systems and methods are disclosed which relate to using wet foam elution for removal of particles from swabs and wipes. This allow users to capture particles from surfaces and recover them by elution into small sample volumes for subsequent detection for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. More specifically, the swabs or wipes are used to collect samples in the standard ways that commercially available swabs and wipes are in use today; from, for instance, food preparation surfaces in food plants, from production equipment in pharmaceutical facilities, for collection of dry powders during bioterrorism event response, and for collection of clinical samples such as nasal, throat, nasopharyngeal, and wounds.
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