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11.发明授权Liquid to liquid biological particle concentrator with disposable fluid path 有权液体与液体生物颗粒浓缩器与一次性流体路径公开(公告)号：US09574977B2
公开(公告)日：2017-02-21
申请号：US14191205
申请日：2014-02-26
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/10 , G01N1/14 , G01N1/34 , G01N1/4077 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 一次性吸头包括用于吸取样品并连接到浓缩单元的流体端口。
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12.发明申请Devices, Systems and Methods for Elution of Particles from Flat Filters 审中-公开用于从扁平过滤器中洗脱颗粒的装置，系统和方法公开(公告)号：US20140076071A1
公开(公告)日：2014-03-20
申请号：US14084403
申请日：2013-11-19
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
IPC: G01N1/22
CPC classification number: G01N1/4077 , B01D46/0032 , B01D46/0067 , B01D46/543 , G01N1/2205 , G01N1/2273 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
Abstract translation: 公开了涉及使用湿泡沫洗脱法从扁平过滤器去除颗粒的装置，系统和方法。 颗粒从大气中捕获到扁平过滤器上。 然后将扁平过滤器放入提取器中，该提取器将湿泡沫流通过扁平过滤器。 泡沫的膨胀用于有效去除捕获的颗粒。 泡沫从捕获的颗粒与过滤器一起流入样品容器。 一旦在样品容器中，泡沫快速分解，留下分析就绪的液体样品。
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公开(公告)号：US11747238B2
公开(公告)日：2023-09-05
申请号：US17209434
申请日：2021-03-23
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/10 , G01N1/14 , G01N1/34 , G01N1/4077 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
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公开(公告)号：US20210148797A1
公开(公告)日：2021-05-20
申请号：US17103900
申请日：2020-11-24
Applicant: InnovaPrep LLC
Inventor： Zachary Allen Packingham , Andrew Edward Page , David Scott Alburty , Steven Dale Graham , Alec Douglas Adolphson
Abstract: The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.
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公开(公告)号：US10953350B2
公开(公告)日：2021-03-23
申请号：US15960483
申请日：2018-04-23
Applicant: InnovaPrep LLC
Inventor： David Scott Alburty , Michael Lee Hornback , Bryan Charles Long , Andrew Edward Page
Abstract: Devices, systems and methods are disclosed which relate to using containers with a multitude of nucleation sites covering a major portion of the inside wall of the container to enable rapid and nearly complete removal of soluble gases from fluid samples, including carbonated beverages and other carbonated fluid samples. A fluid sample is rapidly poured into the described container initiating a catastrophic release of the soluble gas from the sample.
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Patent Agency Ranking
16.发明授权Liquid to liquid biological particle concentrator with disposable fluid path 有权液体与液体生物颗粒浓缩器与一次性流体路径公开(公告)号：US09593359B2
公开(公告)日：2017-03-14
申请号：US14084385
申请日：2013-11-19
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/4077 , B01L3/0275 , B01L2200/026 , B01L2200/0631 , B01L2300/0681 , B01L2300/161 , C12Q1/24 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.
Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 将一次性尖端附接到仪器的所有导管组合成尖端上端的单个连接点。
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公开(公告)号：US20140231256A1
公开(公告)日：2014-08-21
申请号：US14058193
申请日：2013-10-18
Applicant: InnovaPrep LLC
Inventor： Zachary Allen Packingham , Andrew Edward Page , David Scott Alburty , Steven Dale Graham , Alec Douglas Adolphson
IPC: G01N1/40
CPC classification number: G01N1/405 , B01D61/20 , B01D61/22 , B01D63/082 , B01D63/088 , B01D2315/08 , B01D2319/06 , B01D2321/02 , G01N1/40 , G01N1/4055 , G01N1/4077 , G01N2001/4016 , G01N2001/4038 , G01N2001/4088
Abstract: The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.
Abstract translation: 本公开提供了用于从流体样品分级和浓缩颗粒的装置，系统和方法。 这包括一个包含分级过滤器的筒，该过滤器具有一系列减小孔径的多孔表面，用于从流体样品捕获颗粒; 以及与所述盒流体连通的渗透压力源; 其中所述颗粒从所述多孔表面洗脱并以减少的流体体积分配。
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公开(公告)号：US12055469B2
公开(公告)日：2024-08-06
申请号：US18205494
申请日：2023-06-02
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
CPC classification number: G01N1/4077 , B01D46/0032 , B01D46/543 , B01D46/70 , G01N1/2205 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
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公开(公告)号：US20230358643A1
公开(公告)日：2023-11-09
申请号：US18222471
申请日：2023-07-16
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/10 , G01N1/34 , G01N1/4077 , G01N1/14 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
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公开(公告)号：US20230304906A1
公开(公告)日：2023-09-28
申请号：US18205494
申请日：2023-06-02
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
CPC classification number: G01N1/4077 , B01D46/70 , G01N1/2205 , B01D46/0032 , B01D46/543 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
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