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公开(公告)号：US11241532B2
公开(公告)日：2022-02-08
申请号：US16116071
申请日：2018-08-29
申请人： Insulet Corporation
发明人： David Nazzaro , John D'Arco , Jason O'Connor , Ian McLaughlin
摘要： A drug delivery system having a drug delivery device and an associated sensor is provided. The sensor can be associated with a sensing site on user. The drug delivery device can be positioned over the sensor in any rotational position and can be associated with an infusion site on the user. The close positioning of the sensor and the drug delivery device allows data from the sensor to be relayed to the drug delivery device and then on to a remote control device. Further, the drug delivery device can be replaced at the end of its duration of use, which is shorter than the duration of use of the sensor, without disturbing the sensor. Subsequent drug delivery devices can then be used with the sensor while allowing each corresponding infusion site to be changed, thereby providing more efficient operation of the drug delivery system.
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公开(公告)号：US11229740B2
公开(公告)日：2022-01-25
申请号：US16884832
申请日：2020-05-27
申请人： Insulet Corporation
发明人： David Nazzaro
摘要： A wearable drug delivery device that can deliver high volumes of liquid drugs stored in one or more corresponding containers to a patient is provided. The wearable drug delivery device can include first and second containers to store first and second liquid drugs, respectively. A first set of energy transfer spheres can be coupled to a first spring and a first plunger positioned within the first container. A second set of energy transfer spheres can be coupled to a second spring and a second plunger positioned within the second container. The first spring can expand to advance the first set of energy transfer spheres and the first plunger to expel the first liquid drug for delivery to the patient. The second spring can expand to advance the second set of energy transfer spheres and the second plunger to expel the second liquid drug for delivery to the patient.
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公开(公告)号：US11090434B2
公开(公告)日：2021-08-17
申请号：US17079393
申请日：2020-10-23
申请人： Insulet Corporation
发明人： Jason O'Connor , Daniel Allis , David Nazzaro , John R. Bussiere , John D'Arco
摘要： Systems and methods for automatically delivering medication to a user. An automated drug delivery system may include a sensor and a wearable automated drug delivery device. The wearable automated drug delivery device may be configured to couple to the skin of a user and may include a controller and a pump. The pump may be configured to output the medication. The controller may be within the wearable automated drug delivery device. The sensor may be coupled to the user and may be configured to collect information regarding the user. The controller of the wearable automated drug delivery device may use the collected information to locally determine an amount of medication to be output from the wearable automated drug delivery device and cause delivery of the amount of medication.
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公开(公告)号：US10780217B2
公开(公告)日：2020-09-22
申请号：US15809491
申请日：2017-11-10
申请人： Insulet Corporation
发明人： David Nazzaro , Simon Kozin , Maureen McCaffrey
摘要： Ratchet-based drive systems for more reliable and safer drug delivery are provided. The ratchet-based drive systems restrict angular movement and/or linear movement of components that cause a plunger to expel a liquid drug from a drug container. Movement of the components can be restricted to correspond to a predetermined or desired portion of the liquid drug. In the case that control of the drive system is lost or fails, the maximum amount of drug that could be delivered is limited to a known amount, thereby reducing the likelihood of an overdose.
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公开(公告)号：US10441723B2
公开(公告)日：2019-10-15
申请号：US15676289
申请日：2017-08-14
申请人： Insulet Corporation
发明人： David Nazzaro
摘要： Variable fill drug delivery devices for delivering a therapeutic agent to a patient are provided. A variable fill drug delivery device includes a drug container to store a variable amount (or user-selectable amount) of a therapeutic agent. A plunger of the variable fill drug delivery device is positioned in the drug container. An infusion engine of the variable fill device is coupled to the plunger. The infusion engine retains the plunger prior to activation of the variable fill drug delivery device and releases the plunger after activation of the variable fill drug delivery device. After activation, the infusion engine drives the plunger from a first position within the drug container to a second position within the drug container to expel the variable amount of the therapeutic agent from the drug container for delivery to a patient.
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公开(公告)号：US10413665B2
公开(公告)日：2019-09-17
申请号：US15358945
申请日：2016-11-22
申请人： Insulet Corporation
发明人： Robert Rioux , David Nazzaro
摘要： Systems and methods for delivering a medication to a person experiencing an emergency medical event without requiring intervention or action on the part of the person. A device encases a reservoir of medication and a delivery mechanism. Sensors in the housing sense a physical attribute of the person and circuitry monitors information collected by the sensors to determine if the person is experiencing a severe medical condition or event based on the information. An input device on or in the housing, such as a button, may be used or activated by the person if the detected condition or event is a false positive to cancel further action. If the system does not include the button or if the user does not press it in time, the system activates the delivery device and injects the medication into the person.
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公开(公告)号：US20170340827A1
公开(公告)日：2017-11-30
申请号：US15607169
申请日：2017-05-26
申请人： Insulet Corporation
发明人： David Nazzaro , Ian McLaughlin , Simon Kozin , Maureen McCaffrey , Jackie Mac , Alexander Doudoumopoulus , Bhavin Patel
CPC分类号： A61M5/31593 , A61M5/14248 , A61M5/28 , A61M5/31531 , A61M5/32 , A61M5/42 , A61M37/00 , A61M2005/2474 , A61M2005/3142 , A61M2005/31518
摘要： A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.
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公开(公告)号：US11497856B2
公开(公告)日：2022-11-15
申请号：US16534376
申请日：2019-08-07
申请人： Insulet Corporation
发明人： David Nazzaro , Ian McLaughlin , Daniel Allis , Simon Kozin , Maureen McCaffrey
摘要： Systems and methods for monitoring an operational state and/or a fill status of a drug container of a drug delivery device are provided. The drug container can hold a liquid drug. A plunger can be positioned within the drug container. A drive system can advance the plunger to expel the liquid drug from the container. A monitoring system can detect a movement and/or a position of the plunger and/or any component coupled to the plunger. The detection can enable determination of an amount of liquid drug that has been expelled and/or an amount of liquid drug remaining in the drug container. Dosing rates, flow rates, and dosage completion can also be determined.
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公开(公告)号：US11458250B2
公开(公告)日：2022-10-04
申请号：US16428294
申请日：2019-05-31
申请人： Insulet Corporation
IPC分类号： A61M5/168 , A61M5/145 , G01F23/263 , G01F17/00 , A61M5/142
摘要： Reservoir systems with improved wake up and fill volume detection techniques are provided. An example reservoir system may include a flexible reservoir and electrical components for detecting fill volume of the flexible reservoir without adversely affecting performance of the flexible reservoir when receiving or dispensing a liquid drug.
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公开(公告)号：US11439765B2
公开(公告)日：2022-09-13
申请号：US16524647
申请日：2019-07-29
申请人： Insulet Corporation
发明人： David Nazzaro
摘要： Variable fill drug delivery devices for delivering a therapeutic agent to a patient are provided. A variable fill drug delivery device includes a drug container to store a variable amount (or user-selectable amount) of a therapeutic agent. A plunger of the variable fill drug delivery device is positioned in the drug container. An infusion engine of the variable fill device is coupled to the plunger. The infusion engine retains the plunger prior to activation of the variable fill drug delivery device and releases the plunger after activation of the variable fill drug delivery device. After activation, the infusion engine drives the plunger from a first position within the drug container to a second position within the drug container to expel the variable amount of the therapeutic agent from the drug container for delivery to a patient.
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