公开(公告)号：US20180200444A1

公开(公告)日：2018-07-19

申请号：US15875115

申请日：2018-01-19

Applicant: Insulet Corporation

Inventor： Maureen MCCAFFREY ,  David NAZZARO ,  Ian MCLAUGHLIN ,  Simon KOZIN

IPC: A61M5/28 ,  A61M5/24 ,  A61M5/32 ,  A61M5/34

CPC classification number: A61M5/285 ,  A61J1/2089 ,  A61M5/142 ,  A61M5/2455 ,  A61M5/2466 ,  A61M5/31573 ,  A61M5/3293 ,  A61M5/34 ,  A61M2005/31516

Abstract: Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

公开(公告)号：US20220273927A1

公开(公告)日：2022-09-01

申请号：US17669106

申请日：2022-02-10

Applicant: Insulet Corporation

Inventor： Maureen MCCAFFREY ,  Steven CARDINALI ,  Jason O'CONNOR

IPC: A61M37/00 ,  A61M5/142

Abstract: Embodiments of the present disclosure relate to techniques, processes, devices or systems including a floating microneedle assembly decoupled from the device and protected by a pump housing. In one approach, a wearable drug delivery device may include a pump housing including a base attachable to a user, and a microneedle assembly coupled to a cannula. The microneedle assembly may be operable to deliver a liquid drug to the user, wherein the microneedle assembly comprises a carrier positioned proximate an opening of the base, and wherein the carrier comprises a plurality of microneedles operable to extend through the opening of the base to penetrate a skin of the user.

公开(公告)号：US20220105260A1

公开(公告)日：2022-04-07

申请号：US17552407

申请日：2021-12-16

Applicant: Insulet Corporation

Inventor： Steven CARDINALI ,  Daniel ALLIS ,  Ian HANSON ,  Maureen MCCAFFREY ,  Chris GOETCHIUS

IPC: A61M5/142

Abstract: Examples of fluid delivery drive system and/or pump system that creates a vacuum in a fluid line for drawing and expelling fluid are provided. The vacuum may be created by separating two components that are positioned within the sealed fluid line. Once the two components are separated and the fluid is contained within the volume created between the separated components, the two components may be shuttled within the sealed volume. The movement of the two components can seal off an inlet to the fluid line and then open a pathway to an outlet from the fluid line while ensuring the created volume between the two components is maintained constant. The two components can then be moved back together to expel the fluid from the created volume through the outlet for delivery, for example, to a patient. Other examples are disclosed and described.

公开(公告)号：US20200254179A1

公开(公告)日：2020-08-13

申请号：US16859544

申请日：2020-04-27

Applicant: INSULET CORPORATION

Inventor： David NAZZARO ,  Maureen MCCAFFREY ,  Robert F. RIOUX ,  Michael Philip GRAFFEO ,  Ian MCLAUGHLIN ,  Nicholas JANSKY ,  Sam ROSENBLUM ,  David CLARE ,  Robert D. SCHAEFER ,  Daniel P. ALLIS ,  Bryan DILLON ,  Steven BARLETTA ,  Bryan CHOATE ,  Raymond DOBRY ,  John LEFAVOUR

IPC: A61M5/178

Abstract: Systems, components, and methods are disclosed for withdrawing drug from a liquid drug container and transferring drug to a medical device. One or more components may have keying features so that only the correct liquid drug container and medical device are accessed, making sure the medical device is filled with the correct drug. A syringe needle hub may have keying features corresponding to keying features on a cap on the liquid drug container and on the medical device. An alignment device facilitates easy-to-operate filling of a medical device. The alignment device aligns a liquid drug container over a fill port of the medical device and can include components for moving the liquid drug container into engagement with the medical device and for automatically initiating drug transfer to the medical device. A retractable skirt or needle cover protects the needle and is unlocked only when the skirt or needle cover is close to or touching the medical device.

公开(公告)号：US20200179608A1

公开(公告)日：2020-06-11

申请号：US16794689

申请日：2020-02-19

Applicant: Insulet Corporation

Inventor： Maureen MCCAFFREY ,  David NAZZARO ,  Ian MCLAUGHLIN ,  Simon KOZIN

IPC: A61M5/28 ,  A61M5/24 ,  A61M5/34 ,  A61M5/32 ,  A61M5/315 ,  A61M5/142

Abstract: Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

公开(公告)号：US20180236173A1

公开(公告)日：2018-08-23

申请号：US15901082

申请日：2018-02-21

Applicant: Insulet Corporation

Inventor： Maureen MCCAFFREY ,  Ian MCLAUGHLIN

IPC: A61M5/24 ,  A61M5/20

CPC classification number: A61M5/2466 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/14566 ,  A61M5/162 ,  A61M5/2033 ,  A61M5/288 ,  A61M5/3202 ,  A61M2005/14252 ,  A61M2005/1581 ,  A61M2005/1585 ,  A61M2005/208 ,  A61M2005/2474 ,  A61M2005/31518 ,  A61M2205/3386 ,  A61M2205/58 ,  A61M2205/82

Abstract: Systems for piercing a septum of a drug delivery device is disclosed. The drug delivery device may include a needle conduit having an end and a drug container having a septum. The septum piercing mechanism may include a needle support operatively coupled to the needle conduit. The septum piercing mechanism may be movable from a first, unactivated configuration to a second, activated configuration. In the unactivated configuration, the septum seals an interior of the drug container from the end of the needle conduit. In the activated configuration, the end of the needle conduit pierces through the septum placing the needle conduit in fluid communication with the drug container. In one embodiment, activation may cause the needle support to move towards the drug container. In one embodiment, the needle support may be moved by a biasing member. Alternatively, in another embodiment, the needle support may be moved by a cam mechanism.

公开(公告)号：US20240091435A1

公开(公告)日：2024-03-21

申请号：US18466217

申请日：2023-09-13

Applicant: INSULET CORPORATION

Inventor： Maureen MCCAFFREY ,  Soroush KAMRAVA ,  Steven CARDINALI ,  Jeffrey BARNES ,  Kyle BREINGAN ,  Lucas MCGAHREN ,  Daniel BARRETT

IPC: A61M5/145 ,  F04B17/00

CPC classification number: A61M5/1452 ,  F04B17/00 ,  F16H2025/2071

Abstract: Disclosed herein are various embodiments of clutching mechanisms applicable to a dual reservoir pumping mechanism for a drug delivery device, the clutching mechanisms serving to allow translation of one of the reservoirs during the filling process and thereafter connecting the reservoirs together such that one can be driven relative to the other one by means of a leadscrew or other driving mechanism.

公开(公告)号：US20230120570A1

公开(公告)日：2023-04-20

申请号：US18047071

申请日：2022-10-17

Applicant: INSULET CORPORATION

Inventor： Maureen MCCAFFREY ,  Soroush KAMRAVA ,  Ian MCLAUGHLIN

IPC: A61M5/142

Abstract: Disclosed herein are structures for ensuring that the reservoir of drug delivery device is free from any residual air before the device is filled with a liquid drug and put into use. The structures described herein are designed to prevent air from entering the reservoir during the pendency of a shelf life of the drug delivery device and/or to remove any residual air that has entered the reservoir of the drug delivery device prior to it being filled with the liquid drug.

公开(公告)号：US20220331521A1

公开(公告)日：2022-10-20

申请号：US17855910

申请日：2022-07-01

Applicant: Insulet Corporation

Inventor： David NAZZARO ,  Ian MCLAUGHLIN ,  Maureen MCCAFFREY ,  Simon KOZIN ,  Jackie MAC

IPC: A61M5/20 ,  A61M5/142 ,  A61M5/315

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

公开(公告)号：US20220288302A1

公开(公告)日：2022-09-15

申请号：US17674113

申请日：2022-02-17

Applicant: Insulet Corporation

Inventor： Daniel BARRETT ,  Soroush KAMRAVA ,  Maureen MCCAFFREY

IPC: A61M5/142 ,  A61M5/145

Abstract: Disclosed herein are devices and methods for causing the linear translation of a plunger through a reservoir containing a fluid. A flexible member, for example, a wire or a ribbon, is coupled to the plunger and extends through a wall of the reservoir toward which the plunger is being linearly translated. A pulling force on the flexible member caused by a drive mechanism causes the plunger to linearly translate toward the end wall of the reservoir, thereby forcing any fluid contained in the reservoir out of the reservoir through a fluid port.