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    TEST SOLVENT FOR EVALUATING THE COMPATIBILITY OF BIOLOGICALLY ACTIVE SUBSTANCES AND GRAFT COPOLYMERS
    12.
    发明申请
    TEST SOLVENT FOR EVALUATING THE COMPATIBILITY OF BIOLOGICALLY ACTIVE SUBSTANCES AND GRAFT COPOLYMERS 有权
    用于评估生物活性物质和共聚物相容性的试验溶液

    公开(公告)号：US20130118238A1

    公开(公告)日：2013-05-16

    申请号：US13578659

    申请日：2011-02-15

    申请人： Jörg Breitenbach ,  Bernd Liepold ,  Jürgen Weis

    发明人： Jörg Breitenbach ,  Bernd Liepold ,  Jürgen Weis

    IPC分类号： G01N33/487

    CPC分类号： G01N33/487 ,  C08F283/06

    摘要： A liquid mixture, comprising a) at least one compound selected from polyols, polyol ethers wherein at least one hydroxyl group is unetherified, or polyalkylene ethers wherein at least one terminal hydroxyl group is unetherified, b) 1,3-bis(caprolactam-1-yl) butane, and c) diacetoxybutane mimics the solubility properties of a graft copolymer comprising a poly(alkylene glycol) backbone and a vinyl acetate/N-vinylcaprolactam copolymer grafted onto the backbone. In a method for evaluating the compatibility of a biologically active substance with the graft copolymer i) the biologically active sub-stance is brought into contact with the liquid mixture, and ii) the phase behavior of the test system and/or the solubility of the biologically active substance in the mixture is determined.

    摘要翻译： 一种液体混合物，其包含a）至少一种选自多元醇的化合物，其中至少一个羟基未醚化的多元醇醚或其中至少一个末端羟基未醚化的聚亚烷基醚，b）1,3-双（己内酰胺-1 - 环烷基）丁烷，和c）二乙酰氧基丁烷模拟包含聚（亚烷基二醇）主链和接枝到主链上的乙酸乙烯酯/ N-乙烯基己内酰胺共聚物的接枝共聚物的溶解性。 在用于评价生物活性物质与接枝共聚物的相容性的方法中，i）使生物活性物质与液体混合物接触，和ii）测试体系的相行为和/或溶解度 确定混合物中的生物活性物质。

    Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base
    18.
    发明授权
    Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base 失效
    基于肝素，糖胺聚糖或类肝素的制剂，使用制剂和制剂基础

    公开(公告)号：US07393840B2

    公开(公告)日：2008-07-01

    申请号：US10296441

    申请日：2001-05-29

    申请人： Jörg Rosenberg ,  Jörg Breitenbach ,  Dieter Herr ,  Volker Laux ,  Robert Heger

    发明人： Jörg Rosenberg ,  Jörg Breitenbach ,  Dieter Herr ,  Volker Laux ,  Robert Heger

    IPC分类号： A61N31/747

    CPC分类号： A61K9/1635 ,  A61K9/1617 ,  A61K9/1652 ,  A61K31/726 ,  A61K31/727

    摘要： The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of this formulation as drug form for oral administration of at least one heparin, glycosaminoglycan or heparinoid, and also a process for producing the formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as drug form, advantageously using melt extrusion, are described. The lipid component advantageously has active ingredient-promoting properties, while the polymer component is soluble or swellable. At least parts of the lipid component are embedded in a polymer matrix, preferably in the form of a molecular dispersion. The formulations can form emulsions in water or aqueous liquids.

    摘要翻译： 本发明涉及基于至少一种肝素，糖胺聚糖或类肝素的制剂，以及具有脂质组分和聚合物组分的制剂基质。 使用这种制剂作为口服给药至少一种肝素，糖胺聚糖或类肝素的药物形式，以及通过混合制剂组分以形成塑料混合物并在适当时制备制剂作为药物来制备制剂的方法 描述了有利地使用熔体挤出的形式。 脂质组分有利地具有活性成分促进性质，而聚合物组分是可溶的或可溶胀的。 至少部分脂质组分嵌入聚合物基质中，优选以分子分散体的形式。 制剂可以在水或含水液体中形成乳液。