摘要:
A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.
摘要:
A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (FIG. 2).
摘要:
A pharmaceutically acceptable solubilizing composition comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono- and diester is disclosed. The solubilizing composition is useful in the manufacture of a pharmaceutical dosage form which comprises a melt-processed mixture of at least one active ingredient, at least one pharmaceutically acceptable polymer. The active ingredient(s) may be inhibitors of HIV protease. The solubilizing composition enhances the bioavailability of the active ingredient after oral intake.
摘要:
A pharmaceutically acceptable solubilizing composition comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono- and diester is disclosed. The solubilizing composition is useful in the manufacture of a pharmaceutical dosage form which comprises a melt-processed mixture of at least one active ingredient, at least one pharmaceutically acceptable polymer. The active ingredient(s) may be inhibitors of HIV protease. The solubilizing composition enhances the bioavailability of the active ingredient after oral intake.
摘要:
The present invention relates to a method for the characterization of pigments and fillers in which the luminance of a pigmented transparent medium is determined against a dark background. This measurement method is particularly suitable for determining the optical properties of cosmetic fillers.
摘要:
The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.
摘要:
In some aspects of the disclosure, a workpiece retention device for securing plate-like workpieces to a workpiece movement unit of a machine tool includes first and second workpiece clamping elements and a clamping drive by which the workpiece clamping elements can be moved towards one another starting from an initial relative position in order to clamp a workpiece that is arranged between the workpiece clamping elements. The workpiece retention device also includes an adjustment device that can adjust the initial relative position of the workpiece clamping elements.
摘要:
The present invention relates to five-layered pigments based on multicoated platelet-shaped substrates which comprise a layer sequence comprising (A) a layer of SnO2 having a layer thickness of 0.1-50 nm, (B) a high-refractive-index coating consisting of TiO2 in the rutile modification having a layer thickness of 10-800 nm, (C) a colorless coating having a refractive index n≦1.8 having a layer thickness of 20-800 nm, (D) a high-refractive-index coating consisting of SnO2 having a layer thickness of 0.1-50 nm, (E) a layer of TiO2 in the rutile modification having a layer thickness of 10-800 nm, and optionally (F) an outer protective layer, and to the use thereof in paints, coatings, powder coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, as dopants for the laser marking of papers and plastics, in cosmetic formulations and for the preparation of pigment preparations and dry preparations.
摘要:
A modular testing plant comprising at least two building modules which are designed as transportable containers and which each have two side walls and two transverse walls connecting the side walls, wherein at least one building module having a length L2 and a width B2 and designed as a first testing module for receiving a test item is provided, and at least one building module having a length L4 and a width B4 and designed as a first supply module for receiving supply technology is provided, wherein the first supply module is arranged above the first testing module and the length L4 is less than the length L2. To complete the testing plant, at least a third building module designed as a first testing technology module for receiving testing technology is provided, wherein the first testing technology module has two side walls, two transverse walls connecting the side walls, a length L3 and a width B3, wherein the first testing technology module can be placed, in respect of the side wall, laterally next to the first testing module against the side wall, and the width B4 is at least 20% less than the width B2 or B3, which means that the ratio of B4/B2 or the ratio of B4/B3 is at most 2/2.5.
摘要:
A system for predictive front lighting of a vehicle. The system includes a first and second headlamps, a first and second swivel mechanisms and a controller. The first and second headlamps project a beam pattern for illumination of the vehicle path. The controller receives vehicle position data, for example from a GPS system, and accesses a map database to identify a map location of the vehicle. The controller further analyzes the map to determine a most likely path of the vehicle based on the map location and other vehicle heading parameters. The controller then calculates the desired swivel angle of the first and second headlamps based on the most likely path of the vehicle, and the first and second swivel mechanisms manipulate the first and second headlamps to accordingly change the swivel angle of the headlamps.