公开(公告)号：US20050032750A1

公开(公告)日：2005-02-10

申请号：US10759538

申请日：2004-01-20

Applicant: Mitchell Steiner ,  Karen Veverka ,  James Dalton ,  Duane Miller

Inventor： Mitchell Steiner ,  Karen Veverka ,  James Dalton ,  Duane Miller

IPC: A61K20060101 ,  A61K31/165 ,  A61K31/166 ,  A61K31/195 ,  A61K31/22 ,  A61K31/277 ,  A61K31/66

CPC classification number: A61K31/22 ,  A61K31/166

Abstract: The present invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of an Androgen Deficiency in Female (ADIF)-associated condition in a female subject, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, crystal, polymorph, prodrug, or any combination thereof. The present invention further provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, fatigue, depression, anemia, muscle weakness, hair loss, obesity, polycystic ovarian disease, endometriosis, breast cancer, uterine cancer and ovarian cancer due to ADIF in a female subject, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, crystal, polymorph, prodrug, or any combination thereof.

Abstract translation: 本发明提供了通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和治疗雌激素受体调节剂（SARM）化合物的方法来治疗，预防，抑制，抑制或降低女性受试者中雄激素缺乏症（ADIF）相关病症的发生率 或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物，晶体，多晶型物，前药或其任何组合。 本发明还提供一种治疗，预防，抑制或降低性功能障碍，性欲降低，性腺机能减退，肌肉减少症，骨质减少症，骨质疏松症，认知和情绪改变，疲劳，抑郁，贫血，肌肉无力等的发生的方法， 通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和/或其类似物，衍生物异构体，通过对雌性受试者的ADIF引起的脱发，肥胖，多囊卵巢疾病，子宫内膜异位症，乳腺癌，子宫癌和卵巢癌 ，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物，晶体，多晶型物，前药或其任何组合。

公开(公告)号：US5972859A

公开(公告)日：1999-10-26

申请号：US828442

申请日：1997-03-28

Applicant: Terence Farrell ,  Georgia Shafer ,  James Dalton

Inventor： Terence Farrell ,  Georgia Shafer ,  James Dalton

IPC: A61K8/00 ,  A61K8/25 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  A61K8/46 ,  A61K8/86 ,  A61K8/89 ,  A61K8/891 ,  A61K8/90 ,  A61Q19/00 ,  A61Q19/10 ,  C11D1/12 ,  C11D1/90 ,  C11D1/94 ,  C11D3/12 ,  C11D3/18 ,  C11D3/20 ,  C11D3/37 ,  C11D9/22 ,  C11D9/36 ,  C11D10/04 ,  C11D17/00 ,  C11D17/06

CPC classification number: C11D3/3734 ,  C11D1/94 ,  C11D10/04 ,  C11D17/006 ,  C11D17/06 ,  C11D3/1213 ,  C11D3/124 ,  C11D3/18 ,  C11D3/3707 ,  C11D3/373 ,  C11D3/3742 ,  C11D1/123 ,  C11D1/126 ,  C11D1/90

Abstract: Novel chip compositions comprise alkylene glycol, benefit agent and thickening agent (e.g., fumed silica). Use of chips comprising excess of alkylene glycol over benefit agent and thickening agent has been found to allow significant deposition of benefit agent without compromising processing. In a second embodiment, the invention comprises bar compositions comprising mixtures of the chips of the invention and chips containing defined surfactant systems. A process for forming the chips of the invention and a method of enhancing deposition without compromising processing using the chips of the invention are also disclosed.

Abstract translation: 新型芯片组合物包含亚烷基二醇，有益剂和增稠剂（例如热解法二氧化硅）。 已经发现使用包含过量亚烷基二醇的有益试剂和增稠剂的碎屑使得有益试剂显着沉积而不影响加工。 在第二个实施方案中，本发明包括包含本发明的芯片和含有限定的表面活性剂体系的芯片的混合物的棒组合物。 还公开了用于形成本发明的芯片的方法以及使用本发明的芯片不牺牲处理来增强沉积的方法。

公开(公告)号：US12193548B2

公开(公告)日：2025-01-14

申请号：US17842710

申请日：2022-06-16

Applicant: James Dalton

Inventor： James Dalton

IPC: A45C11/00 ,  A45C13/00

Abstract: Broadly, the present invention is of an articulated light transmitting cover apparatus adapted to attach to an article with a display, the cover apparatus including a light transmitting planar cover that is adapted to be removably adjacent to the article display, the light transmitting cover having a cover lengthwise axis and a perpendicularly positioned cover crosswise axis, further the light transmitting cover has a cover primary margin and an opposing cover secondary margin with the cover lengthwise axis spanning therebetween, in addition the light transmitting cover has a cover initial end portion and an opposing cover subsequent end portion with the cover crosswise axis spanning therebetween.

公开(公告)号：USPP27638P3

公开(公告)日：2017-01-31

申请号：US14545245

申请日：2015-04-13

Applicant: Margaret Dalton ,  James Dalton

Inventor： Margaret Dalton ,  James Dalton

IPC: A01H5/02

CPC classification number: A01H5/02

Abstract: A new and distinct form of Dicentra plant characterized by soft, golden to yellow green foliage, large white flowers, and excellent vigor.

Abstract translation: 一种新颖独特的Dicentra植物，其特点是柔软，金黄色的绿色叶子，大白花和优秀的活力。

公开(公告)号：US07988641B2

公开(公告)日：2011-08-02

申请号：US12771151

申请日：2010-04-30

Applicant: Michael McCawley ,  Gary Gasner ,  Ian Christie ,  Tal Gottesman ,  James Dalton

Inventor： Michael McCawley ,  Gary Gasner ,  Ian Christie ,  Tal Gottesman ,  James Dalton

IPC: A61B5/08

CPC classification number: A61B5/085 ,  A61B5/0813

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.

Abstract translation: 一种用于测量肺通气的装置，包括：用于测量空气流量的压力装置; 气溶胶发生装置，其提供将在呼吸循环中的确定点释放的气溶胶颗粒; 具有检测器的喉舌，其在呼吸循环期间测量给定体积的气溶胶颗粒的浓度; 以及被配置为提供肺通气数据作为时间常数的函数的计算设备。

公开(公告)号：US07731666B2

公开(公告)日：2010-06-08

申请号：US11771479

申请日：2007-06-29

Applicant: Michael McCawley ,  Gary Ganser ,  Ian Christie ,  Tal Gottesman ,  James Dalton

Inventor： Michael McCawley ,  Gary Ganser ,  Ian Christie ,  Tal Gottesman ,  James Dalton

IPC: A61B5/00

CPC classification number: A61B5/085 ,  A61B5/0813

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.

Abstract translation: 一种用于测量肺通气的装置，包括：用于测量空气流量的压力装置; 气溶胶发生装置，其提供将在呼吸循环中的确定点释放的气溶胶颗粒; 具有检测器的喉舌，其在呼吸循环期间测量给定体积的气溶胶颗粒的浓度; 以及被配置为提供肺通气数据作为时间常数的函数的计算设备。

公开(公告)号：US20070281906A1

公开(公告)日：2007-12-06

申请号：US11785064

申请日：2007-04-13

Applicant: James Dalton ,  Duane Miller

Inventor： James Dalton ,  Duane Miller

IPC: A61K31/167 ,  A61K31/277 ,  A61K31/32 ,  A61K31/404 ,  A61K31/47 ,  A61K31/555 ,  A61K31/66 ,  A61K31/675 ,  A61P25/02 ,  A61P3/10 ,  A61P9/00

CPC classification number: A61K31/167 ,  A61K31/277 ,  A61K31/32 ,  A61K31/404 ,  A61K31/47 ,  A61K31/555 ,  A61K31/66 ,  A61K31/675

Abstract: This invention provides use of a SARM compound or a composition comprising the same in treating a variety of diseases or conditions in a subject, including, inter-alia, a diabetes disease, and/or disorder such as cardiovascular disease, atherosclerosis, cerebrovascular conditions, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.

Abstract translation: 本发明提供了SARM化合物或其组合物在治疗受试者中的多种疾病或病症中的用途，包括尤其是糖尿病疾病和/或病症如心血管疾病，动脉粥样硬化，脑血管病症， 糖尿病性肾病，糖尿病性神经病变和糖尿病性视网膜病变。

公开(公告)号：US20070274940A1

公开(公告)日：2007-11-29

申请号：US11805392

申请日：2007-05-23

Applicant: Janice Fuls ,  Nancy Rodgers ,  Priscilla Fox ,  James Dalton ,  Harry Towner ,  Daniel Pedersen ,  John Rolando ,  Richard Staub

Inventor： Janice Fuls ,  Nancy Rodgers ,  Priscilla Fox ,  James Dalton ,  Harry Towner ,  Daniel Pedersen ,  John Rolando ,  Richard Staub

IPC: A61K31/185 ,  A61K31/19 ,  A61K31/045

CPC classification number: A01N31/02 ,  A01N25/00 ,  A01N37/04 ,  A01N37/36 ,  A61K31/045 ,  A61K31/192 ,  A61K31/194 ,  A61K31/78 ,  A01N35/02 ,  A01N47/36 ,  A01N37/02 ,  A01N2300/00

Abstract: A method of imparting a rapid antiviral effectiveness, and a persistent antiviral effectiveness, to an animate surface is disclosed. The method includes first treating the animate surface with a preconditioning composition, followed by treating the animate surface with an antiviral composition.

Abstract translation: 公开了赋予动画表面快速抗病毒效能和持久抗病毒效能的方法。 该方法包括首先用预处理组合物处理动画表面，然后用抗病毒组合物处理动画表面。

公开(公告)号：US07174223B2

公开(公告)日：2007-02-06

申请号：US10798847

申请日：2004-03-12

Applicant: James Dalton ,  Peter Single ,  David Money

Inventor： James Dalton ,  Peter Single ,  David Money

IPC: A61N1/00

CPC classification number: A61N1/3754 ,  A61N1/36036 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A virtual wire assembly is disclosed. The assembly comprises a substantially electrically-nonconductive substrate; and a plurality of hermetic feedthroughs each comprising a conductive region extending transversely through the substrate to form a conductive pathway with accessible surfaces at opposing ends thereof, wherein each conductive pathway is electrically isolated from other conductive pathways. In certain embodiments of this aspect of the invention, the substantially electrically-nonconductive substrate is a semiconductor device, and the conductive regions each are comprised of an n-type or a p-type doped semiconductor material. Also disclosed are implanted medical devices requiring electronic or other components to be retained in a hermetic enclosure, such as cochlear and other sensory or neural prosthetic devices.

Abstract translation: 公开了虚拟线组件。 该组件包括基本上非导电的基底; 以及多个密封馈通，每个包括横向延伸通过衬底的导电区域，以在其相对端形成具有可接近表面的导电路径，其中每个导电路径与其它导电路径电隔离。 在本发明的这个方面的某些实施例中，基本上非导电衬底是半导体器件，并且导电区域各自由n型或p型掺杂半导体材料构成。 还公开了植入式医疗装置，其需要将电子或其它部件保持在密封外壳中，例如耳蜗和其他感觉或神经假肢装置。

公开(公告)号：US20060276540A1

公开(公告)日：2006-12-07

申请号：US11353225

申请日：2006-02-14

Applicant: James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

Inventor： James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

IPC: A61K31/277 ,  C07C255/20

CPC classification number: C07C255/60

Abstract: The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor. The selective androgen receptor modulators (SARM) are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia,osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas.

Abstract translation: 本发明涉及雄激素和合成代谢活性的雄激素受体靶向剂（ARTA），其是雄激素受体的非甾体配体。 选择性雄激素受体调节剂（SARM）可用于a）男性避孕; b）治疗各种激素相关病症，例如与老年雄性雄激素降低有关的病症（ADAM），如疲劳，抑郁，性欲降低，性功能障碍，勃起功能障碍，性腺机能减退，骨质疏松症，脱发，贫血， 肥胖，肌营养不良，骨质减少，骨质疏松症，良性前列腺增生，情绪和认知和前列腺癌的改变; c）治疗与男性雄激素降低相关的病症（ADIF），如性功能障碍，性欲降低，性腺机能减退，肌营养不良，骨质减少，骨质疏松症，认知和情绪改变，抑郁症，贫血，脱发，肥胖，子宫内膜异位症，乳腺癌 癌症，子宫癌和卵巢癌; d）治疗和/或预防慢性肌肉消瘦; e）降低前列腺癌的发生率，停止或导致消退; f）口服雄激素替代和/或其他临床治疗和/或诊断领域。