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55 条记录 (耗时 0.039 秒)

    Substituted acylanilides and methods of use thereof
    3.
    发明申请
    Substituted acylanilides and methods of use thereof 有权
    取代的酰基酰苯胺及其使用方法

    公开(公告)号：US20080076829A1

    公开(公告)日：2008-03-27

    申请号：US11892595

    申请日：2007-08-24

    申请人： James Dalton ,  Duane Miller

    发明人： James Dalton ,  Duane Miller

    IPC分类号： C07C255/51 ,  A61K31/167 ,  A61P15/16

    CPC分类号： C07C255/60 ,  C07B2200/07

    摘要： This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.

    摘要翻译： 本发明提供了SARM化合物及其用于治疗受试者中的多种疾病或病症的用途，所述疾病或病症尤其包括肌肉消瘦疾病和/或病症或骨相关疾病和/或病症。

    Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS
    5.
    发明申请
    Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS 审中-公开
    老年男性（ADAM）治疗雄激素下降 - 与SARMS相关的病症

    公开(公告)号：US20060276539A1

    公开(公告)日：2006-12-07

    申请号：US11324753

    申请日：2006-01-04

    申请人： James Dalton ,  Duane Miller ,  Mitchell Steiner ,  Karen Veverka

    发明人： James Dalton ,  Duane Miller ,  Mitchell Steiner ,  Karen Veverka

    IPC分类号： A61K31/277

    CPC分类号： A61K31/277 ,  C07K14/721

    摘要： This invention provides methods for treatment and inhibition of a male subject having an Androgen Decline in Aging Male (ADAM)-associated condition, for example sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, an alteration in cognition and mood, depression, anemia, hair loss, obesity, muscle loss, dry eye, memory loss, benign prostate hyperplasia and/or prostate cancer, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, pro-drug, polymorph, crystal, or any combination thereof.

    摘要翻译： 本发明提供了用于治疗和抑制雄性雄性雄激素降低（ADAM）相关病症的男性受试者的方法，例如性功能障碍，性欲性降低，勃起功能障碍，性腺机能减退，肌肉减少症，骨质减少症，骨质疏松症，认知改变 通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和/或其类似物，通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和/或其类似物， 衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物，前药，多晶型物，晶体或其任何组合。

    Compositions comprising 5-alpha reductase inhibitors and SERMs and methods of use thereof
    8.
    发明申请
    Compositions comprising 5-alpha reductase inhibitors and SERMs and methods of use thereof 审中-公开
    包含5-α还原酶抑制剂和SERM的组合物及其使用方法

    公开(公告)号：US20060019989A1

    公开(公告)日：2006-01-26

    申请号：US10895401

    申请日：2004-07-21

    申请人： Mitchell Steiner ,  Karen Veverka ,  Duane Miller

    发明人： Mitchell Steiner ,  Karen Veverka ,  Duane Miller

    IPC分类号： A61K31/138 ,  A61K31/47

    CPC分类号： A61K31/138 ,  A61K31/47 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

    摘要： This invention provides for combinations of 5 alpha reductase inhibitors and SERMs. These combinations are useful in: 1) preventing prostate carcinogenesis in a subject; 2) preventing the recurrence of, suppressing, inhibiting or reducing the incidence of prostate carcinogenesis in a subject; 3) treating a subject with prostate cancer; 4) suppressing, inhibiting or reducing the incidence of prostate cancer in a subject; 5) treating a subject with pre-malignant lesions of prostate cancer; 6) suppressing, inhibiting or reducing the incidence of pre-malignant lesions of prostate cancer in a subject; 7) reducing the incidence, inhibiting, suppressing, preventing and/or treating androgen-deprivation induced conditions in men suffering from prostate cancer, such as androgen-deprivation induced osteoporosis, bone fractures, loss of bone mineral density (BMD), hot flashes and/or gynecomastia; and 8) treating polycystic ovarian syndrome and reducing the incidence, inhibiting, suppressing, preventing and/or treating diabetes, cardiovascular disease, breast cancer and endometrial cancer in women suffering from polycystic ovarian syndrome.

    摘要翻译： 本发明提供了5种α还原酶抑制剂和SERMs的组合。 这些组合可用于：1）预防受试者的前列腺癌发生; 2）预防受试者中前列腺癌发生的复发，抑制，抑制或降低; 3）用前列腺癌治疗受试者; 4）抑制或抑制受试者前列腺癌的发生率; 5）用前列腺癌的恶性前病变治疗受试者; 6）抑制，抑制或降低患者前列腺癌恶变前病变的发生率; 7）降低患有前列腺癌的男性的雄激素剥夺诱导的骨质疏松症，骨折，骨矿物质密度（BMD），潮热的闪烁和/或损伤的发生，抑制，抑制，预防和/或治疗雄激素剥夺诱导的病症 /或男子乳房发育症 和8）治疗多囊卵巢综合征，降低发生，抑制，抑制，预防和/或治疗患有多囊卵巢综合症的妇女的糖尿病，心血管疾病，乳腺癌和子宫内膜癌。

    Haloacetamide and azide substituted compounds and methods of use thereof
    9.
    发明申请
    Haloacetamide and azide substituted compounds and methods of use thereof 审中-公开
    卤代乙酰胺和叠氮化物取代的化合物及其使用方法

    公开(公告)号：US20050137172A1

    公开(公告)日：2005-06-23

    申请号：US10963761

    申请日：2004-10-14

    申请人： James Dalton ,  Duane Miller ,  Vipin Nair ,  Huiping Xu

    发明人： James Dalton ,  Duane Miller ,  Vipin Nair ,  Huiping Xu

    IPC分类号： A61K31/165 ,  A61K31/21 ,  A61K31/277 ,  A61K31/655 ,  A61K31/66 ,  C07C235/24 ,  C07C255/60 ,  C07D207/44 ,  C07D207/452 ,  A61K31/195 ,  A61K31/32 ,  A61K31/4015

    CPC分类号： C07D207/452 ,  C07C235/24 ,  C07C255/60

    摘要： The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating cancer, preventing cancer, delaying the progression of cancer, treating and/or preventing the recurrence of cancer, suppressing, inhibiting or reducing the incidence of cancer, or inducing apoptosis in a cancer cell. Accordingly, the present invention provides a) methods of treating cancer in a subject; b) methods of preventing cancer in a subject; c) methods of delaying the progression of cancer in a subject; d) methods of treating the recurrence of cancer in a subject; e) methods of preventing the recurrence of cancer in a subject; f) methods of suppressing, inhibiting or reducing the incidence of cancer in a subject; and g) methods of inducing apoptosis in a cancer cell; by administering to the subject an anti-cancer compound of the present invention or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.

    摘要翻译： 本发明涉及一类新的抗癌化合物，其含有卤代乙酰胺或叠氮化物部分，在一个实施方案中是烷化剂。 这些药物单独或组合物可用于治疗癌症，预防癌症，延缓癌症进展，治疗和/或预防癌症复发，抑制，抑制或降低癌症发生率或诱导癌细胞凋亡 癌细胞。 因此，本发明提供了a）在受试者中治疗癌症的方法; b）预防受试者癌症的方法; c）延缓受试者癌症进展的方法; d）治疗患者癌症复发的方法; e）预防受试者癌症复发的方法; f）抑制或抑制受试者癌症发病率的方法; 和g）诱导癌细胞凋亡的方法; 通过向受试者施用本文所述的抗癌化合物或其类似物或代谢物，其N-氧化物，酯，药学上可接受的盐，水合物或其任何组合。

    Treating androgen decline in aging male (ADAM)-associated conditions with SARMS
    10.
    发明申请
    Treating androgen decline in aging male (ADAM)-associated conditions with SARMS 审中-公开
    老年男性（ADAM）治疗雄激素相关性SARS的病情下降

    公开(公告)号：US20050080054A1

    公开(公告)日：2005-04-14

    申请号：US10683161

    申请日：2003-10-14

    申请人： James Dalton ,  Duane Miller ,  Mitchell Steiner ,  Karen Veverka

    发明人： James Dalton ,  Duane Miller ,  Mitchell Steiner ,  Karen Veverka

    IPC分类号： C07K14/72 ,  A61K31/66 ,  A61K31/165 ,  A61K31/195 ,  A61K31/21 ,  A61K31/277 ,  A61K31/32

    CPC分类号： C07K14/721

    摘要： The present invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of an Androgen Decline in Aging Male (ADAM)-associated condition in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, crystal, or any combination thereof. The present invention further provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of sexual dysfunction, decreased sexual libido, erectile dysfunction, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, benign prostate hyperplasia or prostate cancer due to ADAM in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, crystal, or any combination thereof.

    摘要翻译： 本发明提供了通过向受试者施用选择性雄激素受体调节剂（SARM）化合物，治疗，预防，抑制，抑制或降低男性受试者的老年男性（ADAM）相关状态的雄激素下降的发生率的方法 和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物，N-氧化物，前药，多晶型物，晶体或其任何组合。 本发明还提供了治疗，预防，抑制或降低性功能障碍，性欲降低，勃起功能障碍，性腺机能减退，肌肉减少症，骨质减少症，骨质疏松症，认知和情绪改变，抑郁症，贫血，脱发 通过向受试者施用选择性雄激素受体调节剂（SARM）化合物和/或其类似物，衍生物，异构体，代谢产物，药学上可接受的盐，药物产品，由此引起的ADAM在男性受试者中的肥胖，良性前列腺增生或前列腺癌。 水合物，N-氧化物，前药，多晶型物，晶体或其任何组合。