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11.发明授权公开(公告)号：US10589128B2
公开(公告)日：2020-03-17
申请号：US15467915
申请日：2017-03-23
申请人： Susan L. Michaud , Jillian Reno , Nick Ruebel , Mark R. Amato , W. Davis Lee , James P. Bennett
发明人： Susan L. Michaud , Jillian Reno , Nick Ruebel , Mark R. Amato , W. Davis Lee , James P. Bennett
摘要： The invention comprises a method and apparatus for treating a tumor of a patient using positively charged particles, comprising the steps of: (1) providing an approved current version of a radiation treatment plan for treatment of the tumor using the positively charged particles; (2) implementing the current version of the radiation treatment plan using a cancer therapy system comprising a controller linked to a synchrotron; (3) upon identifying an object, using a set of fiducial indicators, in a treatment vector of the radiation treatment plan: generating a modified version of radiation treatment plan and receiving medical doctor approval of the modified version of the radiation treatment plan, the modified version of the radiation plan becoming the current version of the radiation treatment plan; and (4) repeating the steps of implementing and identifying until completion of treatment of the tumor using the positively charged particles.
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公开(公告)号：US10376717B2
公开(公告)日：2019-08-13
申请号：US15483566
申请日：2017-04-10
申请人： James P. Bennett , Susan L. Michaud , Mark R. Amato , Jillian Reno , W. Davis Lee , Nick Ruebel
发明人： James P. Bennett , Susan L. Michaud , Mark R. Amato , Jillian Reno , W. Davis Lee , Nick Ruebel
摘要： The invention comprises a method and apparatus for treating a tumor using positively charged particles having passed through an intervening object, comprising the steps of: predetermining an energy reduction of the positively charged particles resultant from the positively charged particles traversing the intervening object along a beam treatment path as a function of relative rotation of the patient and the beam treatment path; generating a radiation treatment plan adjusting energy of the positively charged particles delivered from the synchrotron to the intervening object to yield a desired beam treatment energy of the positively charged particles entering the tumor after compensating for the energy reduction; and optionally detecting a set of the positively charged particles after traversing the intervening object to yield a signal, where the signal is used with knowledge of energy of the positively charged particles exiting the synchrotron to pre-determine the energy reduction along the beam treatment path.
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13.发明申请公开(公告)号：US20170209715A1
公开(公告)日：2017-07-27
申请号：US15483714
申请日：2017-04-10
申请人： Nick Ruebel , Susan L. Michaud , Mark R. Amato , Jillian Reno , W Davis Lee , James P. Bennett
发明人： Nick Ruebel , Susan L. Michaud , Mark R. Amato , Jillian Reno , W Davis Lee , James P. Bennett
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61B6/032 , A61B6/037 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1081 , A61N5/1082 , A61N2005/1051 , A61N2005/1052 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a method and apparatus for treating a tumor, comprising the steps of: (1) a main controller implementing an initial radiation treatment plan, as a current radiation treatment plan, using positively charged particles delivered from a synchrotron, along a beam transport line, through a nozzle system proximate the treatment room, and into the tumor; (2) concurrent with the step of implementing, imaging the tumor, such as with protons, to generate a current image; (3) upon detection of movement of the tumor relative to surrounding constituents of the patient using the current image, the main controller, using computer implemented code, automatically generating an updated treatment plan, the updated treatment plan becoming the current radiation treatment plan; and (4) repeating the steps of implementing, imaging, and generating an updated treatment plan at least n times, where n is a positive integer of at least one.
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14.发明申请公开(公告)号：US20170197097A1
公开(公告)日：2017-07-13
申请号：US15467915
申请日：2017-03-23
申请人： Susan L. Michaud , Jillian Reno , Nick Ruebel , Mark R. Amato , W. Davis Lee , James P. Bennett
发明人： Susan L. Michaud , Jillian Reno , Nick Ruebel , Mark R. Amato , W. Davis Lee , James P. Bennett
CPC分类号： A61N5/1065 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61B90/39 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1051 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a method and apparatus for treating a tumor of a patient using positively charged particles, comprising the steps of: (1) providing an approved current version of a radiation treatment plan for treatment of the tumor using the positively charged particles; (2) implementing the current version of the radiation treatment plan using a cancer therapy system comprising a controller linked to a synchrotron; (3) upon identifying an object, using a set of fiducial indicators, in a treatment vector of the radiation treatment plan: generating a modified version of radiation treatment plan and receiving medical doctor approval of the modified version of the radiation treatment plan, the modified version of the radiation plan becoming the current version of the radiation treatment plan; and (4) repeating the steps of implementing and identifying until completion of treatment of the tumor using the positively charged particles.
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公开(公告)号：US20190021684A1
公开(公告)日：2019-01-24
申请号：US16131015
申请日：2018-09-13
申请人： Nick Ruebel , Mark R. Amato , Susan L. Michaud , James P. Bennett , Jillian Reno , W. Davis Lee
发明人： Nick Ruebel , Mark R. Amato , Susan L. Michaud , James P. Bennett , Jillian Reno , W. Davis Lee
摘要： The invention comprises a method and apparatus for treating a tumor, comprising the steps of: (1) a main controller sequentially delivering charged particles from a synchrotron along a first beam transport line, through a nozzle system, and to the tumor according to a current version of the radiation treatment plan; (2) concurrent with the step of delivering, generating an image of the tumor using an imaging system; (3) the main controller automatically generating an updated version of the radiation treatment plan using the image, the updated version of the radiation treatment plan becoming the current version of the radiation treatment plan; and (4) repeating the steps of: delivering grouped bunches of the charged particles, generating an image of the tumor, and automatically generating the updated or current version of the radiation treatment plan with optional intervening doctor approval.
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公开(公告)号：US20170203125A1
公开(公告)日：2017-07-20
申请号：US15478927
申请日：2017-04-04
申请人： Mark R. Amato , Susan L. Michaud , James P. Bennett , Jillian Reno , W. Davis Lee , Nick Ruebel
发明人： Mark R. Amato , Susan L. Michaud , James P. Bennett , Jillian Reno , W. Davis Lee , Nick Ruebel
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1071 , A61N5/1077 , A61N5/1081 , A61N5/1082 , A61N2005/1051 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a method for generating a procedure for treating a tumor of a patient using positively charged particles, comprising the steps of: (1) providing a set of treatment goal specifications; (2) generating tomographic images of the tumor using a first set of groups of the positively charge particles delivered from a synchrotron; and (3) a computer implemented algorithm automatically generating a tumor radiation treatment plan, of the tumor using the positively charged particles, using the set of treatment goal specifications and the tomographic images. Optionally, the method automatically updates the radiation treatment plan upon: a detected movement of the tumor relative to surrounding patient constituents and/or upon detection of a previously unforeseen intervening object in a treatment beam path.
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公开(公告)号：US20170203124A1
公开(公告)日：2017-07-20
申请号：US15474916
申请日：2017-03-30
申请人： Jillian Reno , Mark R. Amato , Susan L. Michaud , James P. Bennett , Nick Ruebel , W. Davis Lee
发明人： Jillian Reno , Mark R. Amato , Susan L. Michaud , James P. Bennett , Nick Ruebel , W. Davis Lee
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1081 , A61N5/1082 , A61N2005/1051 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a method for treating a tumor of a patient with positively charged particles in a treatment room, comprising the steps of: (1) controlling a cancer therapy treatment system with a main controller, the main controller comprising hardware and software; (2) generating at least one image of the tumor using at least one imaging system controlled by the main controller; (3) using the at least one image and a software coded set of radiation treatment directives, the main controller auto-generating a radiation treatment plan; and (4) the main controller auto-delivering the positively charged particles, via a beam transport system and a nozzle system, from a synchrotron to the tumor according to the radiation treatment plan.
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18.发明申请公开(公告)号：US20170189722A1
公开(公告)日：2017-07-06
申请号：US15459854
申请日：2017-03-15
申请人： Jillian Reno , Susan L. Michaud , Nick Ruebel , Mark R. Amato , W. Davis Lee , James P. Bennett
发明人： Jillian Reno , Susan L. Michaud , Nick Ruebel , Mark R. Amato , W. Davis Lee , James P. Bennett
IPC分类号： A61N5/10
摘要： The invention comprises a method and apparatus for determining a radiation beam treatment path to a tumor, comprising the steps of: (1) delivering charged particles from an accelerator, along a first beam transport path, through an output nozzle, and along a treatment path to the tumor relative to a calibrated reference beam path from the output nozzle toward a patient position and (2) prior to the step of delivering, a main controller verifying an unobstructed linear path of the treatment path using a set of fiducial indicators positioned at least: on a first element physically affixed and co-movable with the output nozzle and on a moveable object in the treatment room. Optionally, voxels of the treatment beam path and potentially obstructing objects are defined in the treatment room using an axis system relative to the calibrated reference beam path and a reference beam point.
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公开(公告)号：US20180178041A1
公开(公告)日：2018-06-28
申请号：US15892305
申请日：2018-02-08
申请人： W. Davis Lee , Mark R. Amato , Nick Ruebel , Jillian Reno , Susan L. Michaud
发明人： W. Davis Lee , Mark R. Amato , Nick Ruebel , Jillian Reno , Susan L. Michaud
CPC分类号： A61N5/1081 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1051 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a fiducial marker—fiducial detector based treatment room position determination/positioning system apparatus and method of use thereof. A set of fiducial markers and fiducial detectors are used to mark/determine relative position of static and/or moveable objects in a treatment room using photons passing from the markers to the detectors. Further, position and orientation of at least one of the objects is calibrated to a reference line, such as a zero-offset beam treatment line passing through an exit nozzle, which yields a relative position of each fiducially marked object in the treatment room. Treatment calculations are subsequently determined using the reference line and/or points thereon. The treatment calculations are optionally and preferably performed without use of an isocenter point, such as a central point about which a treatment room gantry rotates, which eliminates mechanical errors associated with the isocenter point being an isocenter volume in practice.
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公开(公告)号：US20170113067A1
公开(公告)日：2017-04-27
申请号：US15402739
申请日：2017-01-10
申请人： W. Davis Lee , Mark R. Amato , Nick Ruebel , Jillian Reno , Susan L. Michaud
发明人： W. Davis Lee , Mark R. Amato , Nick Ruebel , Jillian Reno , Susan L. Michaud
IPC分类号： A61N5/10
CPC分类号： A61N5/1081 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1051 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a fiducial marker—fiducial detector based treatment room position determination/positioning system apparatus and method of use thereof. A set of fiducial markers and fiducial detectors are used to mark/determine relative position of static and/or moveable objects in a treatment room using photons passing from the markers to the detectors. Further, position and orientation of at least one of the objects is calibrated to a reference line, such as a zero-offset beam treatment line passing through an exit nozzle, which yields a relative position of each fiducially marked object in the treatment room. Treatment calculations are subsequently determined using the reference line and/or points thereon. The treatment calculations are optionally and preferably performed without use of an isocenter point, such as a central point about which a treatment room gantry rotates, which eliminates mechanical errors associated with the isocenter point being an isocenter volume in practice.
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