公开(公告)号：US12077592B2

公开(公告)日：2024-09-03

申请号：US16743188

申请日：2020-01-15

Applicant: Janssen Biotech, Inc.

Inventor： Ricardo Attar ,  Rajkumar Ganesan ,  Francois Gaudet ,  Bradley J. Heidrich ,  Carmen Baca Jones ,  John Lee ,  Yingzhe Li ,  Sanjaya Singh ,  Sathya Venkataramani

IPC: C07K16/28 ,  A61K9/00 ,  A61P35/00 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K9/0019 ,  A61P35/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor, G-protein coupled receptor family C group 5 member D (GPRC5D), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US12065500B2

公开(公告)日：2024-08-20

申请号：US16412701

申请日：2019-05-15

Applicant: Janssen Biotech, Inc. ,  Stichting VUmc

Inventor： Homer Adams ,  Francois Gaudet ,  Niels Van de Donk ,  Kris Frerichs ,  Christie Verkleij

IPC: C07K16/28 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/30 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/2809 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/71

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics.

公开(公告)号：US20240228618A1

公开(公告)日：2024-07-11

申请号：US18561512

申请日：2022-05-16

Applicant: Janssen Biotech, Inc.

Inventor： Bradley J. Heidrich ,  Priyanka Nair-Gupta ,  Francois Gaudet

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/02

CPC classification number: C07K16/2809 ,  A61P35/02 ,  C07K16/2842 ,  C07K16/2866 ,  C07K16/2884 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/76

Abstract: Disclosed herein is a pharmaceutical composition comprising a T cell redirect therapeutic and an anti-CD44 therapeutic, and uses thereof for killing cancer cells.

公开(公告)号：US11466082B2

公开(公告)日：2022-10-11

申请号：US16418420

申请日：2019-05-21

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Francois Gaudet ,  Ronan McDaid ,  Priyanka Nair-Gupta

IPC: A61P35/02 ,  C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/46 ,  A61K39/00

Abstract: Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.

公开(公告)号：US20190382481A1

公开(公告)日：2019-12-19

申请号：US16418420

申请日：2019-05-21

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Francois Gaudet ,  Ronan McDaid ,  Priyanka Nair-Gupta

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61P35/02 ,  C07K16/46

Abstract: Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.

公开(公告)号：US20190352421A1

公开(公告)日：2019-11-21

申请号：US16412701

申请日：2019-05-15

Applicant: Janssen Biotech, Inc. ,  Stitching VUmc

Inventor： Homer Adams ,  Francois Gaudet ,  Niels Van de Donk ,  Kris Frerichs ,  Christie Verkleij

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/46 ,  A61P35/02 ,  A61K45/06

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics.