-
公开(公告)号：US11603405B2
公开(公告)日：2023-03-14
申请号：US16418082
申请日：2019-05-21
Applicant: Janssen Biotech, Inc.
Inventor： Francois Gaudet , Jill Giles-Komar , Bradley Heidrich , Chichi Huang , Colleen Kane , Ronan McDaid , Jennifer Nemeth-Seay
IPC: C07K16/28 , A61P35/00 , A61K39/395 , C07K16/30 , A61K39/00
Abstract: The present invention relates to antibodies that specifically bind CD3. The present invention relates to antibodies that specifically bind PSMA. The present invention relates to antibodies that specifically bind CD3 and PSMA. The present invention relates to antibodies that specifically bind IL1RAP. The present invention relates to antibodies that specifically bind CD33. The present invention relates to antibodies that specifically bind CD3 and IL1RAP. The present invention relates to antibodies that specifically bind CD3 and CD33. The present invention relates to antibodies that specifically bind TMEFF2. The present invention relates to antibodies that specifically bind CD3 and TMEFF2. The present invention relates to fragments of the antibodies, polynucleotides encoding the antibodies or fragments thereof, and methods of making and using the same.
-
2.发明申请Prostate Specific Membrane Antigen (PSMA) Bispecific Binding Agents and Uses Thereof 审中-公开前列腺特异性膜抗原（PSMA）双特异性结合剂及其用途公开(公告)号：US20160347840A1
公开(公告)日：2016-12-01
申请号：US15148371
申请日：2016-05-06
Applicant: Janssen Biotech, Inc.
Inventor： Glenn Anderson , Rosa Cardoso , Michael Diem , Francois Gaudet , Shalom Goldberg , Benjamin Harman , Linus Hyun , Steven Jacobs , Donna Klein , Yingzhe Li , Jinquan Luo , Ronan McDaid , Jill Mooney , Jennifer Nemeth-Seay , Karyn O'Neil , Steven Pomerantz , Galla Chandra Rao , Tracy Spinka-Doms , Alexey Teplyakov , Leopoldo Luistro , Sheng-Jiun Wu
IPC: C07K16/28 , C07K14/78 , A61K45/06 , C07K16/30 , A61K39/395
CPC classification number: C07K16/2809 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K49/0045 , A61K49/0058 , A61K2039/505 , C07K14/78 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C12Y304/17021
Abstract: Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.
Abstract translation: 本文提供了分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段，其中FN3结构域特异性结合人前列腺特异性膜抗原（PSMA）和第二抗原结合位点免疫特异性结合CD3。 还描述了能够编码所提供的融合蛋白的融合蛋白和相关多核苷酸，以及表达所提供的融合蛋白的细胞。 此外，描述了使用所提供的分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段的方法。
-
公开(公告)号：US11466082B2
公开(公告)日：2022-10-11
申请号：US16418420
申请日：2019-05-21
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Francois Gaudet , Ronan McDaid , Priyanka Nair-Gupta
Abstract: Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
-
公开(公告)号：US20190382481A1
公开(公告)日：2019-12-19
申请号：US16418420
申请日：2019-05-21
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Francois Gaudet , Ronan McDaid , Priyanka Nair-Gupta
Abstract: Anti-CD33 antibodies and antigen-binding fragments thereof and anti-CD33/anti-CD3 bispecific antibodies or antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
-
-
-
Search Results
4
records
(took 0.016 seconds)
