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公开(公告)号：US10954284B2
公开(公告)日：2021-03-23
申请号：US15637276
申请日：2017-06-29
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US10571472B2
公开(公告)日：2020-02-25
申请号：US15845657
申请日：2017-12-18
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Steven Jacobs
Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20180162928A1
公开(公告)日：2018-06-14
申请号：US15840281
申请日：2017-12-13
Applicant: Janssen Biotech, Inc.
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
IPC: C07K14/78 , C07K14/705 , C12N15/85 , A61P35/00
Abstract: FN3 domains that specifically bind to PD-L1, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：US20170362301A1
公开(公告)日：2017-12-21
申请号：US15629090
申请日：2017-06-21
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Alastair King , Steven Jacobs , Shalom Goldberg , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K14/78
Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.
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公开(公告)号：US20170305997A1
公开(公告)日：2017-10-26
申请号：US15637276
申请日：2017-06-29
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
CPC classification number: C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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Patent Agency Ranking
公开(公告)号：US09156887B2
公开(公告)日：2015-10-13
申请号：US13901013
申请日：2013-05-23
Applicant: Janssen Biotech, Inc.
Inventor： Steven Jacobs
CPC classification number: C07K14/315 , C07K14/001 , C07K14/31 , C07K14/47 , C07K2319/01 , C07K2319/31
Abstract: Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.
Abstract translation: 非天然白蛋白结合结构域，编码其的多核苷酸以及制备和使用这些结构域和多核苷酸的方法可用于控制患者治疗分子的半衰期。
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公开(公告)号：US20130316952A1
公开(公告)日：2013-11-28
申请号：US13901013
申请日：2013-05-23
Applicant: Janssen Biotech, Inc.
Inventor： Steven Jacobs
IPC: C07K14/00
CPC classification number: C07K14/315 , C07K14/001 , C07K14/31 , C07K14/47 , C07K2319/01 , C07K2319/31
Abstract: Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in controlling the half-life of therapeutic molecules for patients.
Abstract translation: 非天然白蛋白结合结构域，编码其的多核苷酸以及制备和使用这些结构域和多核苷酸的方法可用于控制患者治疗分子的半衰期。
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公开(公告)号：US20220259289A1
公开(公告)日：2022-08-18
申请号：US17732420
申请日：2022-04-28
Applicant: JANSSEN BIOTECH, INC
Inventor： Michael Diem , Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
IPC: C07K14/78 , A61P35/00 , C12N15/85 , C07K14/705 , G01N33/68 , G01N33/574 , G01N33/53
Abstract: FN3 domains that specifically bind to CD137, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making and using them are useful in therapeutic and diagnostic applications.
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公开(公告)号：US20210206825A1
公开(公告)日：2021-07-08
申请号：US17174524
申请日：2021-02-12
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K14/705 , C07K14/78 , C07K14/71 , C07K16/28 , C07K14/47
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20210032312A1
公开(公告)日：2021-02-04
申请号：US16821064
申请日：2020-03-17
Applicant: Janssen Biotech, Inc.
Inventor： Rebecca Hawkins , Steven Jacobs , Manuel Sepulveda
IPC: C07K14/78 , G01N33/569 , G01N33/68 , G01N33/566 , A61K51/08 , G01N33/53 , A61K49/00 , G01N33/574
Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.
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