公开(公告)号：US20060265507A1

公开(公告)日：2006-11-23

申请号：US11433063

申请日：2006-05-12

申请人： Jaz Banga ,  Nitin Shah ,  Brijesh Patel ,  Amul Patel

发明人： Jaz Banga ,  Nitin Shah ,  Brijesh Patel ,  Amul Patel

IPC分类号： G06F15/16

CPC分类号： H04L67/16 ,  G06F17/30867 ,  H04L67/20 ,  H04L67/22 ,  H04L67/303 ,  H04L67/306

摘要： A system for determining directed media for a user is provided. The exemplary system comprises a media selection optimizer which is configured to determine a directed media component based on a user profile associated, via a device identifier, with a network access device. The media selection optimizer may also utilize access point information, historic information, and access point location-centric information in its determination of the directed media component. The directed media component may then be forward to a media server which provides the corresponding directed media to the user. The directed media may comprise advertisement, coupons, video, music, or any other media which is customizable to the user.

摘要翻译： 提供了一种用于确定用户的定向媒体的系统。 该示例性系统包括媒体选择优化器，其被配置为基于经由设备标识符与网络接入设备相关联的用户简档来确定定向媒体分量。 媒体选择优化器还可以在其定向媒体分量的确定中利用接入点信息，历史信息和接入点位置中心信息。 有向媒体组件然后可以转发到向用户提供相应定向媒体的媒体服务器。 定向媒体可以包括广告，优惠券，视频，音乐或者可以为用户定制的任何其他媒体。

公开(公告)号：US07657594B2

公开(公告)日：2010-02-02

申请号：US11433063

申请日：2006-05-12

申请人： Jaz Banga ,  Nitin Shah ,  Brijesh Patel ,  Amul Patel

发明人： Jaz Banga ,  Nitin Shah ,  Brijesh Patel ,  Amul Patel

IPC分类号： G06F15/16

CPC分类号： H04L67/16 ,  G06F17/30867 ,  H04L67/20 ,  H04L67/22 ,  H04L67/303 ,  H04L67/306

摘要： A system for determining directed media for a user is provided. The exemplary system comprises a media selection optimizer which is configured to determine a directed media component based on a user profile associated, via a device identifier, with a network access device. The media selection optimizer may also utilize access point information, historic information, and access point location-centric information in its determination of the directed media component. The directed media component may then be forward to a media server which provides the corresponding directed media to the user. The directed media may comprise advertisement, coupons, video, music, or any other media which is customizable to the user.

摘要翻译： 提供了一种用于确定用户的定向媒体的系统。 该示例性系统包括媒体选择优化器，其被配置为基于经由设备标识符与网络接入设备相关联的用户简档来确定定向媒体分量。 媒体选择优化器还可以在其定向媒体分量的确定中利用接入点信息，历史信息和接入点位置中心信息。 有向媒体组件然后可以转发到向用户提供相应定向媒体的媒体服务器。 定向媒体可以包括广告，优惠券，视频，音乐或者可以为用户定制的任何其他媒体。

公开(公告)号：US07446227B2

公开(公告)日：2008-11-04

申请号：US11609075

申请日：2006-12-11

申请人： Satyam Nampalli ,  Brijesh Patel ,  Peter Xavier Tharial ,  Ravishanker Kovi

发明人： Satyam Nampalli ,  Brijesh Patel ,  Peter Xavier Tharial ,  Ravishanker Kovi

IPC分类号： C07C211/00

CPC分类号： C07C29/32 ,  C07C209/22 ,  C07C303/28 ,  C07C2603/32 ,  C07C211/32 ,  C07C309/66 ,  C07C33/38

摘要： A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.

摘要翻译： 在惰性气氛下，在四氢呋喃中，在过量的正丁基锂存在下，用氯丙醇与氯丙醇偶合制备式（1）的5-二氢苯并环庚三烯的方法，然后制备式（3）的甲磺酸酯衍生物， 通过使甲胺溶液在甲醇中反应，得到式（4）的无游离碱，从而亲核取代甲磺酸酯基。 此外，本发明方法显示盐酸盐形成和纯化，得到纯度为0.1％w / w的杂质的药物级羟基替康林盐酸盐。

公开(公告)号：US20080139848A1

公开(公告)日：2008-06-12

申请号：US11609075

申请日：2006-12-11

申请人： Satyam S. Nampalli ,  Brijesh Patel ,  Peter Xavier Tharial ,  Ravishanker Kovi

发明人： Satyam S. Nampalli ,  Brijesh Patel ,  Peter Xavier Tharial ,  Ravishanker Kovi

IPC分类号： C07C33/16 ,  C07C211/31

CPC分类号： C07C29/32 ,  C07C209/22 ,  C07C303/28 ,  C07C2603/32 ,  C07C211/32 ,  C07C309/66 ,  C07C33/38

摘要： A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.

摘要翻译： 在惰性气氛下，在四氢呋喃中，在过量的正丁基锂存在下，用氯丙醇与氯丙醇偶合制备式（1）的5-二氢苯并环庚三烯的方法，然后制备式（3）的甲磺酸酯衍生物， 通过使甲胺溶液在甲醇中反应，得到式（4）的无游离碱，从而亲核取代甲磺酸酯基。 此外，本发明方法显示盐酸盐形成和纯化，得到纯度为0.1％w / w的杂质的药物级羟基替康林盐酸盐。

公开(公告)号：US20130005954A1

公开(公告)日：2013-01-03

申请号：US13170471

申请日：2011-06-28

申请人： Ravishanker KOVI ,  Ashish Naik ,  Brijesh Patel ,  Muralikrishna Madala

发明人： Ravishanker KOVI ,  Ashish Naik ,  Brijesh Patel ,  Muralikrishna Madala

IPC分类号： C07H1/06 ,  C07H11/00 ,  C07H1/00

CPC分类号： C07H11/00 ,  C07H1/00 ,  C07H1/06 ,  C07H3/02 ,  C07H3/04 ,  C07H15/04 ,  C07H15/18 ,  C07H19/01

摘要： Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.

摘要翻译： 公开了用于合成因子Xa抗凝血剂磺达肝素和相关化合物的方法。 提供了受保护的五糖中间体，并且通过经脱保护和磺化反应的顺序转化受保护的五糖中间体，可以有效且可扩展地生产磺达肝素钠的方法。

公开(公告)号：US20080242892A1

公开(公告)日：2008-10-02

申请号：US12138924

申请日：2008-06-13

申请人： Satyam Nampalli ,  Brijesh Patel ,  Peter Xavier Tharial ,  Ravishanker Kovi

发明人： Satyam Nampalli ,  Brijesh Patel ,  Peter Xavier Tharial ,  Ravishanker Kovi

IPC分类号： C07C209/16 ,  C07C29/00

CPC分类号： C07C29/32 ,  C07C209/22 ,  C07C303/28 ,  C07C2603/32 ,  C07C211/32 ,  C07C309/66 ,  C07C33/38

摘要： A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.

摘要翻译： 在惰性气氛下，在四氢呋喃中，在过量的正丁基锂存在下，用氯丙醇与氯丙醇偶合制备式（1）的5-二氢苯并环庚三烯的方法，然后制备式（3）的甲磺酸酯衍生物， 通过使甲胺溶液在甲醇中反应，得到式（4）的无游离碱，从而亲核取代甲磺酸酯基。 此外，本发明方法显示盐酸盐形成和纯化，得到纯度为0.1％w / w的杂质的药物级羟基替康林盐酸盐。