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28 条记录 (耗时 0.022 秒)

    Erythromycin derivatives
    12.
    发明授权
    Erythromycin derivatives 失效
    红霉素衍生物

    公开(公告)号：US5656607A

    公开(公告)日：1997-08-12

    申请号：US414503

    申请日：1995-03-31

    申请人： Constantin Agouridas ,  Yannick Benedetti ,  Jean-Francois Chantot ,  Alexis Denis ,  Odile Le Martret

    发明人： Constantin Agouridas ,  Yannick Benedetti ,  Jean-Francois Chantot ,  Alexis Denis ,  Odile Le Martret

    IPC分类号： C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/00

    CPC分类号： C07H17/08 ,  C07H17/00

    摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 23 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and optionally having at least one functional group, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and the wavy line indicates the 10-methyl may have R or S configuration or a mixture of R+S and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.

    摘要翻译： 选自下式的化合物的化合物其中R 1和R 2分别选自氢和至多24个碳原子的任选不饱和烃，任选地被至少一个选自以下的杂原子间隔的杂原子 由氧，硫和氮组成并且任选地具有至少一个官能团或一起形成的基团组成，并且R'1和R'2分别选自氢和任选不饱和的烃，最多达23个 碳原子任选地被至少一个选自氮，氧和硫并且任选具有至少一个官能团的杂原子中断，Z是氢或具有1至18个碳原子的有机羧酸的酰基，波浪线表示 该10-甲基可具有R或S构型或R + S与其无毒的药学上可接受的具有抗生素的酸加成盐的混合物 tic属性。

    Propanal derivatives
    15.
    发明授权
    Propanal derivatives 失效
    丙醛衍生物

    公开(公告)号：US5760233A

    公开(公告)日：1998-06-02

    申请号：US805439

    申请日：1997-02-25

    申请人： Constantin Agouridas ,  Yannick Benedetti ,  Jean-Francois Chantot ,  Alexis Denis ,  Odile Le Martret

    发明人： Constantin Agouridas ,  Yannick Benedetti ,  Jean-Francois Chantot ,  Alexis Denis ,  Odile Le Martret

    IPC分类号： C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/00 ,  C07D215/00 ,  C07C13/00 ,  C07D271/00 ,  C07D277/04

    CPC分类号： C07H17/08 ,  C07H17/00

    摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form ##STR2## and R'.sub.1 and R'.sub.2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 23 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and optionally having at least one functional group, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and the wavy line indicates the 10-methyl may have R or S configuration or a mixture of R+S and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.

    摘要翻译： 选自下式的化合物的化合物其中R 1和R 2分别选自氢和至多24个碳原子的任选不饱和烃，任选地被至少一个选自以下的杂原子间隔的杂原子 由氧，硫和氮组成并且任选地具有至少一个官能团或一起形成的基团组成，并且R'1和R'2分别选自氢和任选不饱和的烃，最多达23个 碳原子任选地被至少一个选自氮，氧和硫并且任选具有至少一个官能团的杂原子中断，Z是氢或具有1至18个碳原子的有机羧酸的酰基，波浪线表示 该10-甲基可具有R或S构型或R + S与其无毒的药学上可接受的具有抗生素的酸加成盐的混合物 tic属性。

    Cephalosporins
    17.
    发明授权
    Cephalosporins 失效
    CEPHALOSPORINS

    公开(公告)号：US5075298A

    公开(公告)日：1991-12-24

    申请号：US265252

    申请日：1988-10-31

    申请人： Jozsef Aszodi ,  Alain Bonnet ,  Jean-Francois Chantot

    发明人： Jozsef Aszodi ,  Alain Bonnet ,  Jean-Francois Chantot

    IPC分类号： C07D519/06 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/04 ,  C07D501/22 ,  C07D501/24 ,  C07D519/00

    CPC分类号： C07D519/00

    摘要： A compound selected from the group consisting of a syn isomer of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms and cycloalkyl of 3 to 6 carbon atoms, all optionally substituted with at least one member of the group consisting of optionally esterified or salified carboxy, alkoxy carbonyl, carbamoyl, dimethylcarbamoyl, amino, alkylamino, dialkylamino, halogen, alkoxy and alkylthio of 1 to 4 carbon atoms, aryl, heterocyclic aryl, arylthio and heterocyclic arylthio optionally substituted by alkyl of 1 to 4 carbon atoms, R.sub.1 is selected from the group consisting of ##STR2## and A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, magnesium, --NH.sub.4 and an organic amine or A is selected from the group consisting of the residue of an easily cleavable ester group or --COOA is --COO-- and the wavy line indicates --CH.sub.2 --R.sub.1 is in the E or Z position and their non-toxic, pharmaceutically acceptable acid addition salts having good antibacterial activity.

    摘要翻译： 选自下式的化合物的顺式异构体的化合物其中R选自氢，1至6个碳原子的烷基，2至6个碳原子的烯基和炔基，以及 具有3至6个碳原子的环烷基，全部由至少一个由任意酯化或成盐的羧基，烷氧基羰基，氨基甲酰基，二甲基氨基甲酰基，氨基，烷基氨基，二烷基氨基，卤素，烷氧基和1至4个碳的烷硫基任意取代 原子，芳基，杂环芳基，芳硫基和任选被1至4个碳原子的烷基取代的杂环芳硫基，R 1选自下列组成的组，A选自氢，碱金属， 碱土金属，镁，-NH 4和有机胺或A选自易裂解酯基团的残基或-COOA为-COO-，波浪线表示-CH2-R1位于E或 Z 位置及其无毒，药学上可接受的酸加成盐具有良好的抗菌活性。

    Erythromycin derivatives, method for preparing same, and use thereof as drugs
    20.
    发明授权
    Erythromycin derivatives, method for preparing same, and use thereof as drugs 有权
    红霉素衍生物，其制备方法及其作为药物的用途

    公开(公告)号：US6096714A

    公开(公告)日：2000-08-01

    申请号：US125959

    申请日：1998-10-09

    申请人： Constantin Agouridas ,  Jean-Francois Chantot

    发明人： Constantin Agouridas ,  Jean-Francois Chantot

    IPC分类号： A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： A subject of the invention is the compounds of formula (I): ##STR1## in which: X represents a CH.sub.2 or SO.sub.2 radical or an oxygen atom, Y represents a (CH.sub.2).sub.m --(CH.dbd.CH).sub.n (CH.sub.2).sub.o radical, with m+n+o.ltoreq.8, n=0 or 1, Ar represents an aryl radical,W represents a hydrogen atom, or the remainder of a carbamate function.The compounds of formula (I) have useful antibiotic properties.

    摘要翻译： PCT No.PCT / FR97 / 00351 Sec。 371日期：1998年10月9日 102（e）日期1998年10月9日PCT 1997年2月27日PCT公布。 第WO97 / 31929号公报 日本公开日1997年9月4日本发明的目的是式（I）的化合物：其中：X表示CH 2或SO 2基或氧原子，Y表示（CH 2）m - （CH = CH）n ）o基团，其中m + n + o = 8，n = 0或1，Ar表示芳基，W表示氢原子或氨基甲酸酯官能团的其余部分。 式（I）化合物具有有用的抗生素性质。