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公开(公告)号：US20110178277A1
公开(公告)日：2011-07-21
申请号：US13078351
申请日：2011-04-01
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K16/2863 , C07K16/2875 , C07K16/36 , C07K16/40 , C07K16/42 , C07K16/4291 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/626 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to heterospecific polypeptide constructs comprising at least one single domain antibody directed against a therapeutic and/or diagnostic target and at least one single domain antibody directed against a serum protein, said construct having a prolonged lifetime in biological circulatory systems. The invention further relates to methods for stabilising VHHs in biological circulatory systems.
摘要翻译： 本发明涉及包含针对治疗和/或诊断靶标的至少一个单域抗体和针对血清蛋白质的至少一个单域抗体的异种多肽构建体，所述构建体在生物循环系统中具有延长的使用寿命。 本发明还涉及在生物循环系统中稳定VHH的方法。
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公开(公告)号：US5864009A
公开(公告)日：1999-01-26
申请号：US480478
申请日：1995-06-06
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans
CPC分类号： C07K14/811 , A61K38/00
摘要： Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
摘要翻译： 蛋白质是有效的抗凝剂并具有至少一个NAP结构域并被描述。 这些具有抗凝血活性的蛋白质可以从天然来源例如线虫中分离出来，化学合成或通过使用各种DNA表达系统的重组方法制备。
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公开(公告)号：US5863894A
公开(公告)日：1999-01-26
申请号：US465380
申请日：1995-06-05
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
CPC分类号： C07K14/811 , A61K38/00
摘要： Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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公开(公告)号：US10005830B2
公开(公告)日：2018-06-26
申请号：US13254266
申请日：2010-03-02
IPC分类号： C07K16/00 , C07K16/18 , C07K16/24 , C07K16/28 , C07K16/36 , A61K9/00 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/26
CPC分类号： C07K16/00 , A61K9/0019 , A61K47/02 , A61K47/14 , A61K47/183 , A61K47/26 , C07K16/18 , C07K16/24 , C07K16/2866 , C07K16/2875 , C07K16/36 , C07K2317/22 , C07K2317/31 , C07K2317/569 , C07K2317/92 , C07K2319/00
摘要： In a broad aspect the present invention generally relates to novel dimer-complexes (herein called “non-fused-dimers” or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (homodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomelic counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.
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公开(公告)号：US09884117B2
公开(公告)日：2018-02-06
申请号：US13393679
申请日：2010-09-03
IPC分类号： C07K16/00 , C07K16/24 , A61K39/00 , A61K39/395 , A61K9/19 , A61K9/00 , A61K47/02 , A61K47/14 , A61K47/26
CPC分类号： A61K39/39591 , A61K9/0019 , A61K47/02 , A61K47/14 , A61K47/26
摘要： Stable formulations are provided that contain immunoglobulin single variable domains at a high concentration. The formulations are useful as pharmaceutical formulation and suitable for subcutaneous administration. The formulations can be transported and stored under various stress conditions. The invention further relates to containers and pharmaceutical units comprising such formulations and to methods for preparing and prophylactic and therapeutic uses of the formulations and pharmaceutical units of the invention.
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16.发明申请AMINO ACID SEQUENCES OF NANOBODIES DIRECTED AGAINST P19 SUBUNIT OF THE HETERODIMERIC CYTOKINE IL-23 审中-公开针对非球形细胞因子IL-23的P19亚单位指导的亚单位氨基酸序列公开(公告)号：US20130109842A1
公开(公告)日：2013-05-02
申请号：US13695312
申请日：2011-04-28
申请人： Veronique De Brabandere , Marc Jozef Lauwereys , Erika Morizzo , Heidi Rommelaere , Ann Union , Gert Verheyden
发明人： Veronique De Brabandere , Marc Jozef Lauwereys , Erika Morizzo , Heidi Rommelaere , Ann Union , Gert Verheyden
CPC分类号： C07K16/244 , C07K14/76 , C07K16/46 , C07K16/468 , C07K2317/22 , C07K2317/569 , C07K2317/94
摘要： The present invention relates to amino acid sequences that are directed against the p19 subunit of IL-23; as well as protein, constructs and compounds comprising the same; and also nucleic acids encoding the same.
摘要翻译： 本发明涉及针对IL-23的p19亚基的氨基酸序列; 以及蛋白质，构建体和包含其的化合物; 以及编码其的核酸。
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公开(公告)号：US20120264917A1
公开(公告)日：2012-10-18
申请号：US13321979
申请日：2010-05-27
申请人： Michael John Scott Saunders , Christophe Blanchetot , Carlo Boutton , Heidi Rommelaere , Johannes Joseph Wilhelmus De Haard , Veronique De Brabandere , Marc Jozef Lauwereys , Erika Morizzo , Ann Union , Gert Verheyden
发明人： Michael John Scott Saunders , Christophe Blanchetot , Carlo Boutton , Heidi Rommelaere , Johannes Joseph Wilhelmus De Haard , Veronique De Brabandere , Marc Jozef Lauwereys , Erika Morizzo , Ann Union , Gert Verheyden
IPC分类号： C07K16/46
CPC分类号： C07K16/244 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/34 , C07K2317/569
摘要： Biparatopic protein constructs that are directed against IL-23, and in particular against the p19 subunit of IL-23. The constructs comprise at least a first binding domain or binding unit directed against a first defined epitope on p19 and at least a second binding domain or binding unit directed against a second defined epitope on p19 (or the p19/p40 interface). The binding domains or binding units may in particular be a domain antibody, a single domain antibody, a dAb or a Nanobody®. The constructs and pharmaceutical compositions comprising the same can be used for the prevention and/or treatment of diseases and disorders associated with IL-23 or IL-23 mediated signaling, such as inflammation and inflammatory disorders such as colitis, Crohn's disease and IBD, infectious diseases, psoriasis, cancer, autoimmune diseases, sarcoidosis, transplant rejection, cystic Fibrosis, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, viral infection, and common variable immunodeficiency.
摘要翻译： 针对IL-23，特别是针对IL-23的p19亚基的双比较性蛋白质构建体。 所述构建体包含至少第一结合结构域或针对p19上的第一定义表位的结合单位，以及针对p19（或p19 / p40界面）上的第二定义表位的至少第二结合结构域或结合单位。 结合域或结合单位特别可以是结构域抗体，单结构域抗体，dAb或纳米抗体。 包含其的构建体和药物组合物可用于预防和/或治疗与IL-23或IL-23介导的信号传导相关的疾病和病症，例如炎症和炎症性疾病如结肠炎，克罗恩病和IBD，感染性 疾病，牛皮癣，癌症，自身免疫疾病，结节病，移植排斥，囊性纤维化，哮喘，慢性阻塞性肺病，类风湿性关节炎，病毒感染和常见的免疫缺陷。
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18.发明申请NOVEL ANTIGEN BINDING DIMER-COMPLEXES, METHODS OF MAKING/AVOIDING AND USES THEREOF 有权新型抗原结合二聚物复合物，其制备方法及其用途公开(公告)号：US20120093839A1
公开(公告)日：2012-04-19
申请号：US13254266
申请日：2010-03-02
CPC分类号： C07K16/00 , A61K9/0019 , A61K47/02 , A61K47/14 , A61K47/183 , A61K47/26 , C07K16/18 , C07K16/24 , C07K16/2866 , C07K16/2875 , C07K16/36 , C07K2317/22 , C07K2317/31 , C07K2317/569 , C07K2317/92 , C07K2319/00
摘要： In a broad aspect the present invention generally relates to novel dimer-complexes (herein called “non-fused-dimers” or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (homodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomelic counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.
摘要翻译： 在广泛的方面，本发明通常涉及包含单可变结构域的新型二聚体复合物（本文称为“非融合二聚体”或NFD），制备这些复合物的方法及其用途。 这些非共价结合的二聚体复合物由两个相同的单体组成，每个单体包含一个或多个单个可变结构域（同源二聚体）或两个不同的单体，其各自包含或多个单个可变结构域（异源二聚体）。 受试者NFD通常改变例如 改善了其单体对应物的结合特性。 本发明的NFD可进一步通过柔性肽或半胱氨酸的连接进行工程改造，以提高稳定性。 本发明还描述了形成这种NFD的条件和可以避免形成这种二聚体的条件。
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公开(公告)号：US5866543A
公开(公告)日：1999-02-02
申请号：US486399
申请日：1995-06-05
申请人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
发明人： George Phillip Vlasuk , Patrick Eric Hugo Stanssens , Joris Hilda Lieven Messens , Marc Jozef Lauwereys , Yves Rene Laroche , Laurent Stephane Jespers , Yannick Georges Jozef Gansemans , Matthew Moyle , Peter W. Bergum
CPC分类号： C07K14/811 , A61K38/00
摘要： Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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