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公开(公告)号：US20120264917A1
公开(公告)日：2012-10-18
申请号：US13321979
申请日：2010-05-27
申请人： Michael John Scott Saunders , Christophe Blanchetot , Carlo Boutton , Heidi Rommelaere , Johannes Joseph Wilhelmus De Haard , Veronique De Brabandere , Marc Jozef Lauwereys , Erika Morizzo , Ann Union , Gert Verheyden
发明人： Michael John Scott Saunders , Christophe Blanchetot , Carlo Boutton , Heidi Rommelaere , Johannes Joseph Wilhelmus De Haard , Veronique De Brabandere , Marc Jozef Lauwereys , Erika Morizzo , Ann Union , Gert Verheyden
IPC分类号： C07K16/46
CPC分类号： C07K16/244 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/34 , C07K2317/569
摘要： Biparatopic protein constructs that are directed against IL-23, and in particular against the p19 subunit of IL-23. The constructs comprise at least a first binding domain or binding unit directed against a first defined epitope on p19 and at least a second binding domain or binding unit directed against a second defined epitope on p19 (or the p19/p40 interface). The binding domains or binding units may in particular be a domain antibody, a single domain antibody, a dAb or a Nanobody®. The constructs and pharmaceutical compositions comprising the same can be used for the prevention and/or treatment of diseases and disorders associated with IL-23 or IL-23 mediated signaling, such as inflammation and inflammatory disorders such as colitis, Crohn's disease and IBD, infectious diseases, psoriasis, cancer, autoimmune diseases, sarcoidosis, transplant rejection, cystic Fibrosis, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, viral infection, and common variable immunodeficiency.
摘要翻译： 针对IL-23，特别是针对IL-23的p19亚基的双比较性蛋白质构建体。 所述构建体包含至少第一结合结构域或针对p19上的第一定义表位的结合单位，以及针对p19（或p19 / p40界面）上的第二定义表位的至少第二结合结构域或结合单位。 结合域或结合单位特别可以是结构域抗体，单结构域抗体，dAb或纳米抗体。 包含其的构建体和药物组合物可用于预防和/或治疗与IL-23或IL-23介导的信号传导相关的疾病和病症，例如炎症和炎症性疾病如结肠炎，克罗恩病和IBD，感染性 疾病，牛皮癣，癌症，自身免疫疾病，结节病，移植排斥，囊性纤维化，哮喘，慢性阻塞性肺病，类风湿性关节炎，病毒感染和常见的免疫缺陷。
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2.发明申请NOVEL ANTIGEN BINDING DIMER-COMPLEXES, METHODS OF MAKING AND USES THEREOF 审中-公开新型抗原结合二聚体复合物，其制备方法及其用途公开(公告)号：US20110091462A1
公开(公告)日：2011-04-21
申请号：US12920862
申请日：2009-03-05
申请人： Peter Casteels , Marc Jozef Lauwereys , Patrick Stanssens , Christine Labeur , Carlo Boutton , Ann Brigé , Hendricus Renerus Jacobus M Hoogenboom , Els Anna Alice Beirnaert
发明人： Peter Casteels , Marc Jozef Lauwereys , Patrick Stanssens , Christine Labeur , Carlo Boutton , Ann Brigé , Hendricus Renerus Jacobus M Hoogenboom , Els Anna Alice Beirnaert
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/00 , C07K16/18 , C07K16/22 , C07K16/2866 , C07K16/36 , C07K2317/22 , C07K2317/569 , C07K2317/626
摘要： In a broad aspect the present invention generally relates to novel dimer-complexes (herein called “non-fused-dimers” or NFDs) comprising single variable domains, methods of making these complexes and uses thereof. These non-covalently bound dimer-complexes consist of two identical monomers that each comprises of one or more single variable domains (homodimers) or of two different monomers that each comprises on or more single variable domains (heterodimers). The subject NFDs have typically altered e.g. improved binding characteristics over their monomeric counterpart. The NFDs of the invention may further be engineered through linkage by a flexible peptide or cysteines in order to improve the stability. This invention also describes conditions under which such NFDs are formed and conditions under which the formation of such dimers can be avoided.
摘要翻译： 在广泛的方面，本发明通常涉及包含单可变结构域的新型二聚体复合物（本文称为“非融合二聚体”或NFD），制备这些复合物的方法及其用途。 这些非共价结合的二聚体复合物由两个相同的单体组成，每个单体包含一个或多个单个可变结构域（同源二聚体）或两个不同的单体，其各自包含或多个单个可变结构域（异源二聚体）。 受试者NFD通常改变例如 改善了其单体对应物的结合特性。 本发明的NFD可进一步通过柔性肽或半胱氨酸的连接进行工程改造，以提高稳定性。 本发明还描述了形成这种NFD的条件和可以避免形成这种二聚体的条件。
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3.发明授权Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same 失效能够结合血清蛋白和化合物的肽，构建体和包含其的多肽公开(公告)号：US08217140B2
公开(公告)日：2012-07-10
申请号：US12424986
申请日：2009-04-16
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译： 本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。
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4.发明申请PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 审中-公开能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽公开(公告)号：US20110243954A1
公开(公告)日：2011-10-06
申请号：US13018047
申请日：2011-01-31
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00
CPC分类号： C07K14/765 , A61K2039/505 , C07K16/18 , C07K16/2866 , C07K16/32 , C07K16/36 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： Provided are pharmaceutical compositions, preparations or formulations including a compounds or constructs that include at least one amino acid sequence that is directed against serum albumin and at least one therapeutic moiety. The pharmaceutical compositions, preparations or formulations are preparations or formulations that are suitable for and/or intended for, e.g., pulmonary administration. Methods for use of the pharmaceutical compositions, preparations or formulations also are provided.
摘要翻译： 提供的药物组合物，制剂或制剂包括包含至少一个针对血清白蛋白和至少一个治疗部分的氨基酸序列的化合物或构建体。 药物组合物，制剂或制剂是适合于和/或用于例如肺部给药的制剂或制剂。 还提供了使用药物组合物，制剂或制剂的方法。
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5.发明申请AMINO ACID SEQUENCES DIRECTED AGAINST HER2 AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF CANCERS AND/OR TUMORS 有权指导针对HER2的氨基酸序列和包含癌症和/或肿瘤的治疗的多肽公开(公告)号：US20110059090A1
公开(公告)日：2011-03-10
申请号：US12744991
申请日：2008-11-27
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/3007 , C07K16/32 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译： 本发明涉及针对表皮生长因子受体2（HER2）的氨基酸序列和纳米抗体，以及包含或基本上由一个或多个这样的氨基酸组成的化合物或构建体，特别是蛋白质和多肽 序列。
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6.发明申请PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 失效能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽公开(公告)号：US20090281277A1
公开(公告)日：2009-11-12
申请号：US12424986
申请日：2009-04-16
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译： 本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。
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公开(公告)号：US20170137520A1
公开(公告)日：2017-05-18
申请号：US15353867
申请日：2016-11-17
申请人： Juha Punnonen , Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Bjorn Victor , David Vlerick
发明人： Juha Punnonen , Edward Bowman , Maribel Beaumont , Marie-Ange Buyse , Carlo Boutton , Bruno Dombrecht , Bjorn Victor , David Vlerick
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K39/39558 , A61K2039/505 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/18 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/76 , C07K2317/92 , Y02A50/403
摘要： The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.
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8.发明授权Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors 有权针对HER2的氨基酸序列和包含它们的多肽用于治疗癌症和/或肿瘤公开(公告)号：US08975382B2
公开(公告)日：2015-03-10
申请号：US12744991
申请日：2008-11-27
CPC分类号： C07K16/2863 , A61K39/3955 , A61K2039/505 , C07K16/3007 , C07K16/32 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/32 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to amino acid sequences and Nanobodies that are directed against Epidermal Growth Factor Receptor 2 (HER2), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.
摘要翻译： 本发明涉及针对表皮生长因子受体2（HER2）的氨基酸序列和纳米抗体，以及包含或基本上由一个或多个这样的氨基酸组成的化合物或构建体，特别是蛋白质和多肽 序列。
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公开(公告)号：US20130330346A1
公开(公告)日：2013-12-12
申请号：US13886530
申请日：2013-05-03
申请人： Zarin Brown , Michelle Bradley , Steven John Charlton , Gino Anselmus Van Heeke , Karen Cromie , Bruno Dombrecht , Soren Steffensen , Judith Baumeister , Marie-Paule Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens
发明人： Zarin Brown , Michelle Bradley , Steven John Charlton , Gino Anselmus Van Heeke , Karen Cromie , Bruno Dombrecht , Soren Steffensen , Judith Baumeister , Marie-Paule Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens
IPC分类号： C07K16/46
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译： 本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。 本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。
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10.发明申请APPARATUS AND METHOD FOR STRUCTURE-BASED PREDICTION OF AMINO ACID SEQUENCES 审中-公开用于氨基酸序列的结构预测的装置和方法公开(公告)号：US20130013279A1
公开(公告)日：2013-01-10
申请号：US13472080
申请日：2012-05-15
CPC分类号： G16B15/00
摘要： The present invention provides methods and apparatus for analyzing a protein structure.
摘要翻译： 本发明提供了分析蛋白质结构的方法和装置。
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