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11.
公开(公告)号:US20070111997A1
公开(公告)日:2007-05-17
申请号:US11537017
申请日:2006-09-29
申请人: Srinivas Kasibhatla , Kevin Hong , Marcus Boehm
发明人: Srinivas Kasibhatla , Kevin Hong , Marcus Boehm
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/519
CPC分类号: C07D487/04 , C07D471/04 , C07D473/00
摘要: Triazolopyrimidines and related compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.
摘要翻译: 三唑并嘧啶和相关化合物被描述和证明或预测可用作热休克蛋白90(HSP90)抑制剂用于治疗和预防各种HSP90介导的病症,例如增殖性疾病。 还描述和要求保护这些化合物的合成和使用方法。
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12.
公开(公告)号:US20050113339A1
公开(公告)日:2005-05-26
申请号:US10946628
申请日:2004-09-20
申请人: Srinivas Kasibhatla , Kevin Hong , Marcus Boehm
发明人: Srinivas Kasibhatla , Kevin Hong , Marcus Boehm
IPC分类号: A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/675 , C07D20060101 , C07D473/12 , C07D487/02 , C07F9/02 , C07F9/6515
CPC分类号: C07D487/04 , C07D471/04 , C07D473/00
摘要: Triazolopyrimidines and related compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.
摘要翻译: 三唑并嘧啶和相关化合物被描述和证明或预测可用作热休克蛋白90(HSP90)抑制剂用于治疗和预防各种HSP90介导的病症,例如增殖性疾病。 还描述和要求保护这些化合物的合成和使用方法。
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公开(公告)号:US20050049263A1
公开(公告)日:2005-03-03
申请号:US10494414
申请日:2002-10-30
申请人: Srinivas Kasibhatla , Kevin Hong , Lin Zhang , Marco Biamonte , Marcus Boehm , Jiandong Shi , Junhua Fan
发明人: Srinivas Kasibhatla , Kevin Hong , Lin Zhang , Marco Biamonte , Marcus Boehm , Jiandong Shi , Junhua Fan
IPC分类号: A61K31/52 , A61P9/10 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/34 , C07D473/40 , A61K31/53 , A61K31/522
CPC分类号: C07D473/00 , C07D473/16 , C07D473/24 , C07D473/34 , C07D473/40
摘要: Novel purine compounds and tautomers and pharmaceutically acceptable salts thereof are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.
摘要翻译: 描述了新的嘌呤化合物和互变异构体及其药学上可接受的盐,以及包含其的药物组合物,包含其的复合物,例如HSP90复合物,及其使用方法。
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公开(公告)号:US20050277619A1
公开(公告)日:2005-12-15
申请号:US11101807
申请日:2005-04-07
申请人: Qun Dang , Mark Erion , M. Reddy , Edward Robinson , Srinivas Kasibhatla , K. Reddy
发明人: Qun Dang , Mark Erion , M. Reddy , Edward Robinson , Srinivas Kasibhatla , K. Reddy
IPC分类号: A61P3/10 , C07F9/6561 , C07F9/6571 , A61K31/675 , C07F9/6512
CPC分类号: C07F9/65616 , C07F9/657181
摘要: Novel purine compounds of Formula 1, pharmaceutically acceptable prodrugs and salts thereof, and their use as fructose 1,6-bisphosphatase inhibitors.
摘要翻译: 式1的新型嘌呤化合物,其药学上可接受的前药和盐,以及它们作为果糖1,6-二磷酸酶抑制剂的用途。
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15.
公开(公告)号:US20080015195A1
公开(公告)日:2008-01-17
申请号:US11842035
申请日:2007-08-20
申请人: Qun Dang , Srinivas Kasibhatla , K. Reddy , Mark Erion , M. Reddy , Atul Agarwal
发明人: Qun Dang , Srinivas Kasibhatla , K. Reddy , Mark Erion , M. Reddy , Atul Agarwal
IPC分类号: A61K31/53 , A61K31/33 , A61K31/341 , A61K31/41 , A61K31/4155 , A61K31/4164 , A61K31/421 , A61P3/10 , C07D213/02 , C07D277/62 , C07D277/02 , C07D263/02 , C07D257/04 , C07D253/02 , C07D241/00 , C07D239/00 , C07D233/00 , C07D231/00 , C07D307/02 , C07D293/06 , C07D285/12 , A61P9/00 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/44 , A61K31/4965 , A61K31/505
CPC分类号: C07F9/4006 , C07F9/5728 , C07F9/58 , C07F9/650952 , C07F9/6512 , C07F9/653 , C07F9/65324 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345 , C07F9/65583 , C07F9/65586 , C07F9/657181 , C07F9/6578 , C07F9/65846
摘要: Novel FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
摘要翻译: 式I和X的新型FBPase抑制剂可用于治疗与血糖升高相关的糖尿病和其它病症。
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16.
公开(公告)号:US20070232571A1
公开(公告)日:2007-10-04
申请号:US11742023
申请日:2007-04-30
申请人: Qun Dang , Srinivas Kasibhatla , K. Reddy , Mark Erion , M. Reddy , Atul Agarwal
发明人: Qun Dang , Srinivas Kasibhatla , K. Reddy , Mark Erion , M. Reddy , Atul Agarwal
CPC分类号: C07F9/4006 , C07F9/5728 , C07F9/58 , C07F9/650952 , C07F9/6512 , C07F9/653 , C07F9/65324 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345 , C07F9/65583 , C07F9/65586 , C07F9/657181 , C07F9/6578 , C07F9/65846
摘要: Novel FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
摘要翻译: 式I和X的新型FBPase抑制剂可用于治疗与血糖升高相关的糖尿病和其它病症。
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公开(公告)号:US20050004077A1
公开(公告)日:2005-01-06
申请号:US10900718
申请日:2004-07-28
申请人: Tao Jiang , Srinivas Kasibhatla , K. Reddy
发明人: Tao Jiang , Srinivas Kasibhatla , K. Reddy
IPC分类号: A61K31/665 , A61K31/675 , A61P3/10 , A61P43/00 , C07F9/44 , C07F9/58 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6539 , C07F9/6541 , C07F9/655 , C07F9/6561
CPC分类号: C07F9/6561 , C07F9/4465 , C07F9/65515
摘要: Novel bisamidate phosphonate prodrugs of FBPase inhibitors of the Formula IA: and their use in the treatment of diabetes and other conditions associated with elevated blood glucose.
摘要翻译: 式IA的FBP酶抑制剂的新型双酰胺基膦酸酯前体药物及其在治疗与血糖升高相关的糖尿病和其它病症中的用途。
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