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公开(公告)号:US20080214605A1
公开(公告)日:2008-09-04
申请号:US12067572
申请日:2006-09-19
申请人: Jeffrey S. Albert , Gerard M. Koether , Cristobal Alhambra , James Kang , Thomas R. Simpson , James Woods , Yan Li
发明人: Jeffrey S. Albert , Gerard M. Koether , Cristobal Alhambra , James Kang , Thomas R. Simpson , James Woods , Yan Li
IPC分类号: A61K31/472 , C07D215/00 , C07D215/38 , A61P25/00 , A61P3/00 , A61P1/00 , A61P15/00 , A61P35/04
CPC分类号: C07D215/52 , C07D401/12
摘要: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 式Ⅰ的化合物,其中R 1,A,R 2,R 3,R 4,R 4, 其中n,m和q如说明书中所述,药学上可接受的盐,制备方法,药物组合物及其使用方法。
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公开(公告)号:US20080194622A1
公开(公告)日:2008-08-14
申请号:US11917820
申请日:2006-06-21
申请人: Thomas R. Simpson , James Kang , Jeffrey S. Albert , Cristobal Alhambra , Gerard M. Koether , James Woods , Yan Li
发明人: Thomas R. Simpson , James Kang , Jeffrey S. Albert , Cristobal Alhambra , Gerard M. Koether , James Woods , Yan Li
CPC分类号: C07D215/52
摘要: Compounds of Formula I wherein R1, A, R2, R3, R4, R5 n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 式Ⅰ的化合物,其中R 1,A,R 2,R 3,R 4,R 4, m和q如说明书,药学上可接受的盐,制备方法,药物组合物含有及其使用方法所述。
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公开(公告)号:US07608628B2
公开(公告)日:2009-10-27
申请号:US11609166
申请日:2006-12-11
申请人: Thomas R. Simpson , James Kang , Jeffrey S. Albert , Cristobal Alhambra , Gerald M. Koether , James Woods , Yan Li
发明人: Thomas R. Simpson , James Kang , Jeffrey S. Albert , Cristobal Alhambra , Gerald M. Koether , James Woods , Yan Li
CPC分类号: C07D215/38 , C07D215/14 , C07D215/52
摘要: Compounds of Formula II wherein R1, A, R2, R3, R4, R5, R8, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 式II的化合物,其中R 1,A,R 2,R 3,R 4,R 5,R 8,n,m和q如说明书中所述,药学上可接受的盐,制备方法,药物组合物及其使用方法。
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公开(公告)号:US20080287492A1
公开(公告)日:2008-11-20
申请号:US12063146
申请日:2006-08-09
申请人: Jeffrey S. Albert , Cristobal Alhambra , James Kang , Gerard M. Koether , Thomas R. Simpson , James Woods , Yan Li
发明人: Jeffrey S. Albert , Cristobal Alhambra , James Kang , Gerard M. Koether , Thomas R. Simpson , James Woods , Yan Li
IPC分类号: A61K31/4709 , C07D401/06 , A61P11/00 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00
CPC分类号: C07D401/06
摘要: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and p are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 式Ⅰ的化合物,其中R 1,A,R 2,R 3,R 4,R 4, > 5,n,m和p如说明书中所述,药学上可接受的盐,制备方法,药物组合物和其使用方法。
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公开(公告)号:US20060089346A1
公开(公告)日:2006-04-27
申请号:US10528640
申请日:2003-10-02
申请人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
发明人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
IPC分类号: A61K31/554 , A61K31/55 , A61K31/551
CPC分类号: C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要: Compounds having the formula (1) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid B protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译: 具有式(1)的药物组合物及其用于治疗与淀粉样蛋白B蛋白质产生和神经障碍如阿尔茨海默病相关的神经障碍的方法。 这些化合物抑制γ分泌酶,从而抑制淀粉样蛋白β蛋白的产生,从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号:US20080076752A1
公开(公告)日:2008-03-27
申请号:US11844451
申请日:2007-08-24
申请人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
发明人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
IPC分类号: A61K31/554 , A61P25/28
CPC分类号: C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译: 具有式(I)的药物组合物和含有它们的药物组合物及其用于治疗与淀粉样蛋白β蛋白生产和神经障碍如阿尔茨海默病有关的神经障碍的方法。 这些化合物抑制γ分泌酶,从而抑制淀粉样蛋白β蛋白的产生,从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号:US07294622B2
公开(公告)日:2007-11-13
申请号:US10528640
申请日:2003-10-02
申请人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Bhikkappa Shenvi , Thomas Simpson , James Woods
发明人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Bhikkappa Shenvi , Thomas Simpson , James Woods
IPC分类号: C07D223/16 , C07D267/14 , C07D281/06 , A61K31/55 , A61P25/28
CPC分类号: C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译: 具有式(I)的药物组合物和含有它们的药物组合物及其用于治疗与淀粉样蛋白β蛋白生产和神经障碍如阿尔茨海默病有关的神经障碍的方法。 这些化合物抑制γ分泌酶,从而抑制淀粉样蛋白β蛋白的产生,从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号:US20060183732A1
公开(公告)日:2006-08-17
申请号:US10549271
申请日:2004-03-10
申请人: Keith Herzog , Robert Jacobs , Jianxing Kang , Thomas Simpson , James Woods
发明人: Keith Herzog , Robert Jacobs , Jianxing Kang , Thomas Simpson , James Woods
IPC分类号: A61K31/55 , C07D223/12
CPC分类号: C07D409/12 , C07D223/12 , C07K5/06026 , C07K5/06043 , C07K5/06191
摘要: This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. The present invention relates to the treatment of neurological disorders related to amyloid β-protein production such as Alzheimer's disease.
摘要翻译: 本发明涉及具有式(I)的新化合物及其药物组合物及其使用方法。 这些新型化合物抑制分泌酶,从而抑制淀粉样蛋白β蛋白的产生,从而起到防止淀粉样蛋白神经沉积的形成的作用。 本发明涉及治疗与淀粉样蛋白β-蛋白生产相关的神经障碍,例如阿尔茨海默病。
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公开(公告)号:US20110136804A1
公开(公告)日:2011-06-09
申请号:US12940449
申请日:2010-11-05
申请人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
发明人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
IPC分类号: A61K31/5377 , C07D471/22 , A61K31/438 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/16 , A61P25/34
CPC分类号: C07D491/22
摘要: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
摘要翻译: 式I的烟碱型乙酰胆碱受体配体,其中X,n,R 1和R 2如说明书中所述,非对映异构体,对映异构体,药学上可接受的盐,制备方法,含药物组合物及其使用方法。
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公开(公告)号:US07842803B2
公开(公告)日:2010-11-30
申请号:US11749820
申请日:2007-05-17
申请人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
发明人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
IPC分类号: C07D265/30 , A61K31/5375
CPC分类号: C07D491/22
摘要: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
摘要翻译: 式I的烟碱型乙酰胆碱受体配体,其中X,n,R 1和R 2如说明书中所述,非对映异构体,对映异构体,药学上可接受的盐,制备方法,含药物组合物及其使用方法。
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