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公开(公告)号:US20080139600A1
公开(公告)日:2008-06-12
申请号:US11749820
申请日:2007-05-17
申请人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
发明人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
IPC分类号: A61K31/439 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/18 , C07D491/22
CPC分类号: C07D491/22
摘要: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
摘要翻译: 式I的烟碱型乙酰胆碱受体配体,其中X,n,R 1和R 2如说明书中所述,非对映异构体,对映异构体,药学上可接受的盐,制备方法 ,含有的药物组合物及其使用方法。
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公开(公告)号:US20110136804A1
公开(公告)日:2011-06-09
申请号:US12940449
申请日:2010-11-05
申请人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
发明人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
IPC分类号: A61K31/5377 , C07D471/22 , A61K31/438 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/16 , A61P25/34
CPC分类号: C07D491/22
摘要: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
摘要翻译: 式I的烟碱型乙酰胆碱受体配体,其中X,n,R 1和R 2如说明书中所述,非对映异构体,对映异构体,药学上可接受的盐,制备方法,含药物组合物及其使用方法。
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公开(公告)号:US07842803B2
公开(公告)日:2010-11-30
申请号:US11749820
申请日:2007-05-17
申请人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
发明人: Hui-Fang Chang , Christopher Holmquist , Eifion Phillips , Timothy Piser , Thomas Simpson , Rebecca Urbanek , James Woods , Hui Xiong
IPC分类号: C07D265/30 , A61K31/5375
CPC分类号: C07D491/22
摘要: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
摘要翻译: 式I的烟碱型乙酰胆碱受体配体,其中X,n,R 1和R 2如说明书中所述,非对映异构体,对映异构体,药学上可接受的盐,制备方法,含药物组合物及其使用方法。
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公开(公告)号:US20070179172A1
公开(公告)日:2007-08-02
申请号:US10553915
申请日:2004-05-04
申请人: Christopher Becker , Jeanne Comstock , William Michne , Megan Murphy , Eifion Phillips , James Rosamond , Thomas Simpson
发明人: Christopher Becker , Jeanne Comstock , William Michne , Megan Murphy , Eifion Phillips , James Rosamond , Thomas Simpson
IPC分类号: A61K31/4743 , A61K31/4741 , A61K31/473
CPC分类号: A61K31/4709 , A61K31/47
摘要: Compounds of Formula I or Formula II wherein R1, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
摘要翻译: 其中R 1,X和Ar如说明书中所述的式I或式II化合物,其药学上可接受的盐,制备方法,含有它们的药物组合物及其在治疗中的用途,特别是 用于治疗与烟碱传播减少有关的病症。
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公开(公告)号:US20090054445A1
公开(公告)日:2009-02-26
申请号:US12162002
申请日:2007-01-25
申请人: Jeffrey Albert , Cristobal Alhambra , James Kang , Gerard Koether , Yan Li , Thomas Simpson , James Woods
发明人: Jeffrey Albert , Cristobal Alhambra , James Kang , Gerard Koether , Yan Li , Thomas Simpson , James Woods
IPC分类号: A61K31/4709 , C07D215/20 , A61K31/501 , A61P25/00 , C07D403/12
CPC分类号: C07D405/12 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Compounds of Formula I wherein R1, A, R2, n, R3, m, R4, R5 and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 式I化合物,其中R 1,A,R 2,n,R 3,m,R 4,R 5和q如本说明书中所述,药学上可接受的盐,制备方法,药物组合物及其使用方法。
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公开(公告)号:US08071621B2
公开(公告)日:2011-12-06
申请号:US12576319
申请日:2009-10-09
申请人: Thomas Simpson , James Kang , Jeffrey Albert , Cristobal Alhambra , Gerard Koether , James Woods , Yan Li
发明人: Thomas Simpson , James Kang , Jeffrey Albert , Cristobal Alhambra , Gerard Koether , James Woods , Yan Li
CPC分类号: C07D215/38 , C07D215/14 , C07D215/52
摘要: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 其中R 1,A,R 2,R 3,R 4,R 5,R 8,n,m,q和r如说明书中所述的式I化合物,药学上可接受的盐,制备方法,含药物组合物和使用方法 相同。
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公开(公告)号:US20100029717A1
公开(公告)日:2010-02-04
申请号:US12576319
申请日:2009-10-09
申请人: Thomas Simpson , James Kang , Jeffrey Albert , Cristobal Alhambra , Gerard Koether , James Woods , Yan Li
发明人: Thomas Simpson , James Kang , Jeffrey Albert , Cristobal Alhambra , Gerard Koether , James Woods , Yan Li
CPC分类号: C07D215/38 , C07D215/14 , C07D215/52
摘要: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 其中R 1,A,R 2,R 3,R 4,R 5,R 8,n,m,q和r如说明书中所述的式I化合物,药学上可接受的盐,制备方法,含药物组合物和使用方法 相同。
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公开(公告)号:US20080076752A1
公开(公告)日:2008-03-27
申请号:US11844451
申请日:2007-08-24
申请人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
发明人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
IPC分类号: A61K31/554 , A61P25/28
CPC分类号: C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译: 具有式(I)的药物组合物和含有它们的药物组合物及其用于治疗与淀粉样蛋白β蛋白生产和神经障碍如阿尔茨海默病有关的神经障碍的方法。 这些化合物抑制γ分泌酶,从而抑制淀粉样蛋白β蛋白的产生,从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号:US07294622B2
公开(公告)日:2007-11-13
申请号:US10528640
申请日:2003-10-02
申请人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Bhikkappa Shenvi , Thomas Simpson , James Woods
发明人: Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Bhikkappa Shenvi , Thomas Simpson , James Woods
IPC分类号: C07D223/16 , C07D267/14 , C07D281/06 , A61K31/55 , A61P25/28
CPC分类号: C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译: 具有式(I)的药物组合物和含有它们的药物组合物及其用于治疗与淀粉样蛋白β蛋白生产和神经障碍如阿尔茨海默病有关的神经障碍的方法。 这些化合物抑制γ分泌酶,从而抑制淀粉样蛋白β蛋白的产生,从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号:US20080293765A1
公开(公告)日:2008-11-27
申请号:US12096997
申请日:2006-12-11
申请人: Jeffrey Albert , Cristobal Alhambra , James Kang , Gerard Koether , Thomas Simpson , James Woods , Yan Li
发明人: Jeffrey Albert , Cristobal Alhambra , James Kang , Gerard Koether , Thomas Simpson , James Woods , Yan Li
IPC分类号: A61K31/47 , A61P25/00 , A61P3/04 , A61P29/00 , A61P11/00 , A61P35/00 , C07D215/38 , C07D215/48
CPC分类号: C07D215/38 , C07D215/14 , C07D215/52
摘要: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译: 其中R 1,A,R 2,R 3,R 4,R 5,R 8,n,m,q和r如说明书中所述的式I化合物,药学上可接受的盐,制备方法,含药物组合物和使用方法 相同。
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