公开(公告)号：US20070213686A1

公开(公告)日：2007-09-13

申请号：US11347008

申请日：2006-02-03

申请人： Vandana Mathur ,  Craig Ball ,  Jeffrey Elkins ,  Harry Goodson ,  Samir Patel

发明人： Vandana Mathur ,  Craig Ball ,  Jeffrey Elkins ,  Harry Goodson ,  Samir Patel

IPC分类号： A61B19/00

CPC分类号： A61M5/1723 ,  A61B90/00 ,  A61B2017/22082 ,  A61M5/007 ,  A61M25/0068 ,  A61M2005/1403 ,  A61M2025/0037 ,  A61M2025/1045

摘要： An apparatus and method particularly useful in treatments and therapies directed at the kidneys such as the prevention of radiocontrast nephropathy (RCN) arising from diagnostic procedures using iodinated contrast materials. A series of treatment schemes are provided based upon local therapeutic agent delivery to the kidneys that can be used as a prophylactic treatment for patients undergoing interventional procedures that have been identified as being at an elevated risk for developing RCN as well as for low risk patients. The methods may include pre-exposure and post contrast exposure treatments alone or in combination with the local delivery of therapeutic agents to the kidneys. Among the agents identified for such treatments are normal saline and the vasodilators papaverine and fenoldopam mesylate and appropriate dosing is provided.

摘要翻译： 特别适用于针对肾脏的治疗和疗法的装置和方法，例如使用碘化造影剂的诊断程序引起的放射性对比肾病（RCN）的预防。 提供了一系列基于局部治疗剂递送到肾脏的治疗方案，其可用作对已经被鉴定为发展RCN和低风险患者的高风险的介入手术的患者的预防性治疗。 所述方法可以包括单独的暴露前曝光和造影后处理，或与治疗剂局部递送到肾脏的方法。 鉴定用于这种治疗的药剂是生理盐水，并且提供了血管扩张剂罂粟碱和甲磺酸芬诺多胺，并提供适当的给药。

公开(公告)号：US20060149350A1

公开(公告)日：2006-07-06

申请号：US11295735

申请日：2005-12-05

申请人： Samir Patel ,  Harry Goodson ,  Jeffrey Elkins ,  Craig Ball ,  Vandana Mathur

发明人： Samir Patel ,  Harry Goodson ,  Jeffrey Elkins ,  Craig Ball ,  Vandana Mathur

IPC分类号： A61F2/06

CPC分类号： A61F2/954 ,  A61B2017/00331 ,  A61B2017/22068 ,  A61B2017/22071 ,  A61F2/013 ,  A61F2/958 ,  A61F2002/065 ,  A61F2002/821 ,  A61F2002/9517 ,  A61F2002/9528 ,  A61M25/1002

摘要： Bifurcated delivery assemblies provide bilateral access to first and second branch lumens extending from a main body space or lumen in a patient. One or more interventional devices are combined with the delivery assemblies for delivery s into one or both of the branch lumens. Bilateral renal stenting or embolic protection procedures are performed using the combination delivery/interventional device assemblies. Fluids may also be injected or aspirated from the assemblies. A bifurcated catheter has a first fluid port located on one bifurcation branch, a second fluid port located on a second branch of the bifurcation, and a third fluid port positioned so as to be located within a vena cava when the first and second ports are positioned bilaterally within first and second renal veins.

摘要翻译： 分叉输送组件提供从患者的主体空间或内腔延伸的第一和第二分支腔的双向通路。 将一个或多个介入装置与输送组件组合以用于输送到分支腔中的一个或两个。 使用组合递送/介入装置组件进行双侧肾支架置入或栓塞保护程序。 流体也可以从组件注入或吸出。 分叉导管具有位于一个分叉分支上的第一流体端口，位于分叉的第二分支上的第二流体端口和位于第一和第二端口定位的位于腔静脉内的第三流体端口 在第一和第二肾静脉内双侧。

公开(公告)号：US20050267010A1

公开(公告)日：2005-12-01

申请号：US11129101

申请日：2005-05-13

申请人： Harry Goodson ,  Samir Patel ,  Craig Ball ,  Jeffrey Elkins

发明人： Harry Goodson ,  Samir Patel ,  Craig Ball ,  Jeffrey Elkins

IPC分类号： A61K38/17 ,  A61K38/22 ,  A61M25/00 ,  A61M25/04

CPC分类号： A61M25/0041 ,  A61K38/2242 ,  A61M25/0054 ,  A61M25/04 ,  A61M2025/0681 ,  A61M2210/1085

摘要： The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and methods of use.

摘要翻译： 本发明涉及用于将局部肾递送给患有充血性心力衰竭和其他病症风险的受试者的系统和方法。 本发明包括用于肾药物递送的装置和使用方法。

公开(公告)号：US20050197624A1

公开(公告)日：2005-09-08

申请号：US11073421

申请日：2005-03-04

申请人： Harry Goodson ,  Craig Ball ,  Jeffrey Elkins

发明人： Harry Goodson ,  Craig Ball ,  Jeffrey Elkins

IPC分类号： A61M25/00 ,  A61M25/06 ,  A61M29/00

CPC分类号： A61M25/0662 ,  A61M25/0032 ,  A61M25/007

摘要： A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.

摘要翻译： 双腔引导器护套提供对患者的至少一个肾动脉和至少一个外周血管的通路。 导引鞘包括近端毂，其包括第一和第二端口，第一腔和第二腔。 第一腔从第一端口延伸到第一远端孔并且具有足够的长度，使得当第一端口位于患者外部时，第一远端孔可定位在患者肾动脉起点处或其附近的腹主动脉中。 所述第二腔从所述第二端口延伸到第二远端孔，具有比所述第一腔的长度更短的长度，并且构造成允许导管装置通过所述第二腔并进入或穿过对侧的髂动脉 导引鞘的插入点进入患者。