公开(公告)号：US20070213686A1

公开(公告)日：2007-09-13

申请号：US11347008

申请日：2006-02-03

申请人： Vandana Mathur ,  Craig Ball ,  Jeffrey Elkins ,  Harry Goodson ,  Samir Patel

发明人： Vandana Mathur ,  Craig Ball ,  Jeffrey Elkins ,  Harry Goodson ,  Samir Patel

IPC分类号： A61B19/00

CPC分类号： A61M5/1723 ,  A61B90/00 ,  A61B2017/22082 ,  A61M5/007 ,  A61M25/0068 ,  A61M2005/1403 ,  A61M2025/0037 ,  A61M2025/1045

摘要： An apparatus and method particularly useful in treatments and therapies directed at the kidneys such as the prevention of radiocontrast nephropathy (RCN) arising from diagnostic procedures using iodinated contrast materials. A series of treatment schemes are provided based upon local therapeutic agent delivery to the kidneys that can be used as a prophylactic treatment for patients undergoing interventional procedures that have been identified as being at an elevated risk for developing RCN as well as for low risk patients. The methods may include pre-exposure and post contrast exposure treatments alone or in combination with the local delivery of therapeutic agents to the kidneys. Among the agents identified for such treatments are normal saline and the vasodilators papaverine and fenoldopam mesylate and appropriate dosing is provided.

摘要翻译： 特别适用于针对肾脏的治疗和疗法的装置和方法，例如使用碘化造影剂的诊断程序引起的放射性对比肾病（RCN）的预防。 提供了一系列基于局部治疗剂递送到肾脏的治疗方案，其可用作对已经被鉴定为发展RCN和低风险患者的高风险的介入手术的患者的预防性治疗。 所述方法可以包括单独的暴露前曝光和造影后处理，或与治疗剂局部递送到肾脏的方法。 鉴定用于这种治疗的药剂是生理盐水，并且提供了血管扩张剂罂粟碱和甲磺酸芬诺多胺，并提供适当的给药。

公开(公告)号：US20060149350A1

公开(公告)日：2006-07-06

申请号：US11295735

申请日：2005-12-05

申请人： Samir Patel ,  Harry Goodson ,  Jeffrey Elkins ,  Craig Ball ,  Vandana Mathur

发明人： Samir Patel ,  Harry Goodson ,  Jeffrey Elkins ,  Craig Ball ,  Vandana Mathur

IPC分类号： A61F2/06

CPC分类号： A61F2/954 ,  A61B2017/00331 ,  A61B2017/22068 ,  A61B2017/22071 ,  A61F2/013 ,  A61F2/958 ,  A61F2002/065 ,  A61F2002/821 ,  A61F2002/9517 ,  A61F2002/9528 ,  A61M25/1002

摘要： Bifurcated delivery assemblies provide bilateral access to first and second branch lumens extending from a main body space or lumen in a patient. One or more interventional devices are combined with the delivery assemblies for delivery s into one or both of the branch lumens. Bilateral renal stenting or embolic protection procedures are performed using the combination delivery/interventional device assemblies. Fluids may also be injected or aspirated from the assemblies. A bifurcated catheter has a first fluid port located on one bifurcation branch, a second fluid port located on a second branch of the bifurcation, and a third fluid port positioned so as to be located within a vena cava when the first and second ports are positioned bilaterally within first and second renal veins.

摘要翻译： 分叉输送组件提供从患者的主体空间或内腔延伸的第一和第二分支腔的双向通路。 将一个或多个介入装置与输送组件组合以用于输送到分支腔中的一个或两个。 使用组合递送/介入装置组件进行双侧肾支架置入或栓塞保护程序。 流体也可以从组件注入或吸出。 分叉导管具有位于一个分叉分支上的第一流体端口，位于分叉的第二分支上的第二流体端口和位于第一和第二端口定位的位于腔静脉内的第三流体端口 在第一和第二肾静脉内双侧。

公开(公告)号：US06238693B1

公开(公告)日：2001-05-29

申请号：US09300092

申请日：1999-04-27

申请人： Robert R. Luther ,  Dawn McGuire ,  Vandana Mathur ,  David J. Ellis

发明人： Robert R. Luther ,  Dawn McGuire ,  Vandana Mathur ,  David J. Ellis

IPC分类号： A61F1302

CPC分类号： A61K9/7023 ,  A61K31/55

摘要： Transdermal administration of fenoldopam, both the racemic mixture and the active R-fenoldopam enantiomer, is described. Also described are transdermal patches for therapeutically effective transdermal administration of racemic fenoldopam and its active R-fenoldopam enantiomer to a subject in need of treatment for impaired renal function or hypertension.

摘要翻译： 描述了非诺多泮的经皮给药，外消旋混合物和活性R-非诺多泮对映异构体。 还描述了用于对需要治疗肾功能受损或高血压的受试者进行治疗有效透皮给予外消旋非诺多泮及其活性R-非诺多泮对映体的透皮贴片。