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公开(公告)号:US20070288052A1
公开(公告)日:2007-12-13
申请号:US11787162
申请日:2007-04-13
IPC分类号: A61M29/04
CPC分类号: A61F6/225 , A61B17/12022 , A61B17/12099 , A61B17/12109 , A61B17/12118 , A61B17/12136 , A61B17/12186 , A61B17/1219 , A61B2017/00495 , A61F2/07 , A61F2/90 , A61F2002/077 , A61K9/0024 , A61L24/001 , A61L24/0031 , A61L31/146 , A61L2430/36 , A61M25/10 , A61M31/00 , A61M31/005 , A61M2025/0057 , A61M2210/1425
摘要: Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first and second inlet ports and first and second outlet ports, respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.
摘要翻译: 使用配置成递送两种或更多种流动性预聚物溶液而不过早交联的递送系统来提供原位形成水凝胶体系的方法和装置。 输送系统分别包括分别的第一和第二入口和第一和第二出口连接的第一和第二流体,并且可以包括球囊,柔性远端区域,混合室或可操纵的远端。 还描述了适用于本发明方法和装置的多组分水凝胶体系。
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公开(公告)号:US20050080445A1
公开(公告)日:2005-04-14
申请号:US10756181
申请日:2004-01-13
CPC分类号: A61F6/225 , A61B17/12022 , A61B17/12099 , A61B17/12109 , A61B17/12118 , A61B17/12136 , A61B17/12186 , A61B17/1219 , A61B2017/00495 , A61F2/07 , A61F2/90 , A61F2002/077 , A61K9/0024 , A61L24/001 , A61L24/0031 , A61L31/146 , A61L2430/36 , A61M25/10 , A61M31/00 , A61M31/005 , A61M2025/0057 , A61M2210/1425
摘要: Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first and second inlet ports and first and second outlet ports, respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.
摘要翻译: 使用配置成递送两种或更多种流动性预聚物溶液而不过早交联的递送系统来提供原位形成水凝胶体系的方法和装置。 输送系统分别包括分别的第一和第二入口和第一和第二出口连接的第一和第二流体,并且可以包括球囊,柔性远端区域,混合室或可操纵的远端。 还描述了适用于本发明方法和装置的多组分水凝胶体系。
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公开(公告)号:US20060193899A1
公开(公告)日:2006-08-31
申请号:US11406791
申请日:2006-04-19
申请人: Amarpreet Sawhney
发明人: Amarpreet Sawhney
CPC分类号: A61L33/0064 , A61B17/12022 , A61B17/12099 , A61B17/12104 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B2017/00898 , A61K6/0014 , A61K6/0067 , A61K9/0024 , A61K9/0036 , A61K9/0085 , A61K9/2027 , A61L24/0015 , A61L24/0031 , A61L31/145 , A61L31/16 , A61L2300/418 , A61K6/0035 , C08L39/06 , A61K6/0038 , C08L33/14 , C08L71/02
摘要: Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.
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公开(公告)号:US20050266086A1
公开(公告)日:2005-12-01
申请号:US10858516
申请日:2004-06-01
申请人: Amarpreet Sawhney
发明人: Amarpreet Sawhney
IPC分类号: A61K9/00 , A61K9/14 , A61K31/765
CPC分类号: A61K9/0034 , A61K31/765
摘要: Certain embodiments herein are directed to method of preventing adhesions in a uterus by introducing a flowable material into a uterus to tamponade a surface of the uterus. Such a material may be a hydrogel. The hydrogel may be formed in situ from at least one precursor, for example, a hydrophilic polymer with functional groups for forming covalent bonds.
摘要翻译: 本文的某些实施例涉及通过将可流动材料引入子宫来填塞子宫表面以防止子宫粘连的方法。 这样的材料可以是水凝胶。 水凝胶可以由至少一种前体形成,例如具有用于形成共价键的官能团的亲水性聚合物。
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公开(公告)号:US5627233A
公开(公告)日:1997-05-06
申请号:US465949
申请日:1995-06-06
申请人: Jeffrey A. Hubbell , Donald Elbert , Jennifer L. Hill-West , Paul D. Drumheller , Sanghamitra Chowdhury , Amarpreet Sawhney
发明人: Jeffrey A. Hubbell , Donald Elbert , Jennifer L. Hill-West , Paul D. Drumheller , Sanghamitra Chowdhury , Amarpreet Sawhney
IPC分类号: A61L27/00 , A61K9/50 , A61K47/48 , A61L31/06 , A61L33/00 , C08G63/91 , C08G73/00 , C08G81/00 , C08G81/02 , C08L77/00 , C08L79/00 , C08L101/00 , C09D187/00 , C08L1/00 , C08G69/48
CPC分类号: C08G81/00 , A61K47/48238 , A61K47/48315 , A61K9/5031 , A61K9/5073 , A61L31/06
摘要: Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.
摘要翻译: 本文描述的是用于抑制细胞和细胞,细胞和组织以及组织和组织之间的粘附和免疫识别的多功能聚合物材料。 聚合物材料的一个组分很好地吸附到细胞或组织上,而聚合物材料的其它组分不能很好地吸附到组织上。 使用不带电荷的水溶性聚合物(多项式)作为非结合成分,使用在生理pH(聚阳离子)下带正电的水溶性聚合物作为组织结合成分。 当双官能聚合物材料接触组织时,组织结合组分结合并因此固定所连接的非结合组分,其然后将一般远离组织表面延伸,并空间阻断其它组织的附着。 该方法和组合物可用于抑制手术后粘连的形成,保护受损的血管免受血栓形成和再狭窄,并降低附着依赖性肿瘤细胞的转移程度。
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公开(公告)号:US5567440A
公开(公告)日:1996-10-22
申请号:US471390
申请日:1995-06-06
申请人: Jeffrey A. Hubbell , Donald Elbert , Jennifer L. Hill-West , Paul D. Drumbeller , Sanghamitra Chowdhury , Amarpreet Sawhney
发明人: Jeffrey A. Hubbell , Donald Elbert , Jennifer L. Hill-West , Paul D. Drumbeller , Sanghamitra Chowdhury , Amarpreet Sawhney
IPC分类号: A61L27/00 , A61K9/50 , A61K47/48 , A61L31/06 , A61L33/00 , C08G63/91 , C08G73/00 , C08G81/00 , C08G81/02 , C08L77/00 , C08L79/00 , C08L101/00 , C09D187/00 , A61K9/14
CPC分类号: C08G81/00 , A61K47/48238 , A61K47/48315 , A61K9/5031 , A61K9/5073 , A61L31/06
摘要: Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.
摘要翻译: 本文描述的是用于抑制细胞和细胞,细胞和组织以及组织和组织之间的粘附和免疫识别的多功能聚合物材料。 聚合物材料的一个组分很好地吸附到细胞或组织上,而聚合物材料的其它组分不能很好地吸附到组织上。 使用不带电荷的水溶性聚合物(多项式)作为非结合成分,使用在生理pH(聚阳离子)下带正电的水溶性聚合物作为组织结合成分。 当双官能聚合物材料接触组织时,组织结合组分结合并因此固定所连接的非结合组分,其然后将一般远离组织表面延伸,并空间阻断其它组织的附着。 该方法和组合物可用于抑制手术后粘连的形成,保护受损的血管免受血栓形成和再狭窄,并降低附着依赖性肿瘤细胞的转移程度。
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