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11.发明申请OLIGONUCLEOTIDES WITH ALTERNATING SEGMENTS OF LOCKED AND NON-LOCKED NUCLEOTIDES 有权具有锁定和非锁定核心的替代部分的寡核苷酸公开(公告)号：US20090209748A1
公开(公告)日：2009-08-20
申请号：US10717434
申请日：2003-11-18
申请人： Charlotte Albaek Thrue , Christoph Rosenbohm , Henrik Frydenlund Hansen , Majken Westergaard , Nikolaj Dam Mikkelsen , Signe Christensen , Troels Koch , Daniel Sejer Pedersen , Miriam Frieden
发明人： Charlotte Albaek Thrue , Christoph Rosenbohm , Henrik Frydenlund Hansen , Majken Westergaard , Nikolaj Dam Mikkelsen , Signe Christensen , Troels Koch , Daniel Sejer Pedersen , Miriam Frieden
IPC分类号： C07H21/00
CPC分类号： C12N15/113 , A61K31/7088 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/344 , C12N2320/30 , C12N2320/51
摘要： The present invention is directed to novel oligonucleotides with improved antisense properties. The novel oligonucleotides comprise at least one Locked Nucleic Acid (LNA) selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides. The present invention also provides a new class of pharmaceuticals which comprise antisense oligonucleotides and are useful in antisense therapy.
摘要翻译： 本发明涉及具有改进的反义性质的新型寡核苷酸。 所述新型寡核苷酸包含至少一种选自β-D-thio / amino-LNA或α-L-氧基/硫代/氨基-LNA的锁定核酸（LNA）。 包含LNA的寡核苷酸还可以包括DNA和/或RNA核苷酸。 本发明还提供了一类新的药物，其包含反义寡核苷酸并且可用于反义治疗。
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公开(公告)号：US07846911B2
公开(公告)日：2010-12-07
申请号：US12580126
申请日：2009-10-15
IPC分类号： A61K48/00
CPC分类号： A61K31/7088 , A61K31/70 , A61K38/00 , A61K45/06 , C07H21/04 , C12N15/113 , C12N2310/315 , C12N2310/3231 , C12N2310/331 , C12N2310/334 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , A61K2300/00
摘要： Oligonucleotides directed against the hypoxia-inducible factor-1α (HIP-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
摘要翻译： 提供针对缺氧诱导因子-1α（HIP-1α）基因的寡核苷酸用于调节HIF-1α的表达。 组合物包含靶向编码HIF-1α的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节HIF-1α表达和治疗与缺氧诱导因子-1α相关疾病的方法。 疾病的例子是癌症和先兆子痫。 寡核苷酸可以由脱氧核糖核苷，核酸类似物或锁定核酸（LNA）或其组合构成。
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公开(公告)号：US08357670B2
公开(公告)日：2013-01-22
申请号：US13477825
申请日：2012-05-22
IPC分类号： A16K48/00
CPC分类号： A61K31/7088 , A61K31/70 , A61K38/00 , A61K45/06 , C07H21/04 , C12N15/113 , C12N2310/315 , C12N2310/3231 , C12N2310/331 , C12N2310/334 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , A61K2300/00
摘要： Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
摘要翻译： 提供针对缺氧诱导因子-1α（HIF-1α）基因的寡核苷酸用于调节HIF-1α的表达。 组合物包含靶向编码HIF-1α的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节HIF-1α表达和治疗与缺氧诱导因子-1α相关疾病的方法。 疾病的例子是癌症和先兆子痫。 寡核苷酸可以由脱氧核糖核苷，核酸类似物或锁定核酸（LNA）或其组合构成。
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公开(公告)号：US08207140B2
公开(公告)日：2012-06-26
申请号：US12913173
申请日：2010-10-27
IPC分类号： A61K48/00
CPC分类号： A61K31/7088 , A61K31/70 , A61K38/00 , A61K45/06 , C07H21/04 , C12N15/113 , C12N2310/315 , C12N2310/3231 , C12N2310/331 , C12N2310/334 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , A61K2300/00
摘要： Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
摘要翻译： 提供针对缺氧诱导因子-1α（HIF-1α）基因的寡核苷酸用于调节HIF-1α的表达。 组合物包含靶向编码HIF-1α的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节HIF-1α表达和治疗与缺氧诱导因子-1α相关疾病的方法。 疾病的例子是癌症和先兆子痫。 寡核苷酸可以由脱氧核糖核苷，核酸类似物或锁定核酸（LNA）或其组合构成。
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公开(公告)号：US20110224285A1
公开(公告)日：2011-09-15
申请号：US12913173
申请日：2010-10-27
IPC分类号： A61K31/7088 , A61P35/00 , A61P31/12
CPC分类号： A61K31/7088 , A61K31/70 , A61K38/00 , A61K45/06 , C07H21/04 , C12N15/113 , C12N2310/315 , C12N2310/3231 , C12N2310/331 , C12N2310/334 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , A61K2300/00
摘要： Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
摘要翻译： 提供针对缺氧诱导因子-1α（HIF-1α）基因的寡核苷酸用于调节HIF-1α的表达。 组合物包含靶向编码HIF-1α的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节HIF-1α表达和治疗与缺氧诱导因子-1α相关疾病的方法。 疾病的例子是癌症和先兆子痫。 寡核苷酸可以由脱氧核糖核苷，核酸类似物或锁定核酸（LNA）或其组合构成。
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公开(公告)号：US20100093839A1
公开(公告)日：2010-04-15
申请号：US12580126
申请日：2009-10-15
CPC分类号： A61K31/7088 , A61K31/70 , A61K38/00 , A61K45/06 , C07H21/04 , C12N15/113 , C12N2310/315 , C12N2310/3231 , C12N2310/331 , C12N2310/334 , C12N2310/3341 , C12N2310/335 , C12N2310/341 , A61K2300/00
摘要： Oligonucleotides directed against the hypoxia-inducible factor-1α (HIP-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
摘要翻译： 提供针对缺氧诱导因子-1α（HIP-1α）基因的寡核苷酸用于调节HIF-1α的表达。 组合物包含靶向编码HIF-1α的核酸的寡核苷酸，特别是反义寡核苷酸。 提供了使用这些化合物调节HIF-1α表达和治疗与缺氧诱导因子-1α相关疾病的方法。 疾病的例子是癌症和先兆子痫。 寡核苷酸可以由脱氧核糖核苷，核酸类似物或锁定核酸（LNA）或其组合构成。
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