公开(公告)号：US08410144B2

公开(公告)日：2013-04-02

申请号：US12751310

申请日：2010-03-31

申请人： Nivedita Namdev ,  Manish Tandon ,  Jianqiang Wang ,  Audra Dalton ,  David Vensel ,  Rocio Palma ,  Mark A. Ashwell ,  Neil Westlund

发明人： Nivedita Namdev ,  Manish Tandon ,  Jianqiang Wang ,  Audra Dalton ,  David Vensel ,  Rocio Palma ,  Mark A. Ashwell ,  Neil Westlund

IPC分类号： A61K31/404 ,  C07D401/04

CPC分类号： C07D401/04

摘要： The present invention relates to substituted indolo-pyridinone compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted indolo-pyridinone compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的吲哚 - 吡啶酮化合物及其合成方法。 本发明还涉及含有取代的吲哚并吡啶酮化合物的药物组合物和通过将这些化合物或药物组合物给予需要的受试者来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：US20120108574A1

公开(公告)日：2012-05-03

申请号：US13286294

申请日：2011-11-01

申请人： Mark A. Ashwell ,  Sudharshan Eathiraj ,  Anton Filikov ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Rocio Palma ,  David Vensel ,  Shin Iimura ,  Akiko Shiina ,  Kenichi Yoshida ,  Takanori Yamazaki ,  Akihisa Matsuda

发明人： Mark A. Ashwell ,  Sudharshan Eathiraj ,  Anton Filikov ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Rocio Palma ,  David Vensel ,  Shin Iimura ,  Akiko Shiina ,  Kenichi Yoshida ,  Takanori Yamazaki ,  Akihisa Matsuda

IPC分类号： A61K31/551 ,  A61P35/00 ,  C07D487/14

CPC分类号： C07D471/14 ,  A61K31/551 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention relates to substituted benzo-imidazo-pyrido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-imidazo-pyrido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的苯并咪唑并 - 吡啶并二氮杂化合物及其合成方法。 本发明还涉及含有取代的苯并咪唑并 - 吡啶并二氮杂化合物的药物组合物和通过将这些化合物和药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：US20110172203A1

公开(公告)日：2011-07-14

申请号：US12981127

申请日：2010-12-29

申请人： Mark A. Ashwell ,  Chris Brassard ,  Anton Filikov ,  Jason Hill ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Nivedita Namdev ,  Robert Nicewonger ,  Rocio Palma ,  Manish Tandon ,  David Vensel ,  Akihisa Matsuda ,  Shin Iimura ,  Yuko Yamamoto

发明人： Mark A. Ashwell ,  Chris Brassard ,  Anton Filikov ,  Jason Hill ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Nivedita Namdev ,  Robert Nicewonger ,  Rocio Palma ,  Manish Tandon ,  David Vensel ,  Akihisa Matsuda ,  Shin Iimura ,  Yuko Yamamoto

IPC分类号： A61K31/397 ,  C07D471/04 ,  A61K31/437 ,  C07D401/14 ,  A61K31/506 ,  A61K31/497 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/553 ,  A61K31/496 ,  A61K31/438 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的咪唑并吡啶基 - 氨基吡啶化合物和合成这些化合物的方法。 本发明还涉及含有取代的咪唑并吡啶基 - 氨基吡啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：US20100239526A1

公开(公告)日：2010-09-23

申请号：US12649762

申请日：2009-12-30

申请人： Syed M. Ali ,  Mark Ashwell ,  Chris Brassard ,  Audra Dalton ,  Anton Filikov ,  Jason Hill ,  Nivedita Namdev ,  Rocio Palma ,  Manish Tandon ,  David Vensel ,  Jianqiang Wang ,  Neil Westlund

发明人： Syed M. Ali ,  Mark Ashwell ,  Chris Brassard ,  Audra Dalton ,  Anton Filikov ,  Jason Hill ,  Nivedita Namdev ,  Rocio Palma ,  Manish Tandon ,  David Vensel ,  Jianqiang Wang ,  Neil Westlund

IPC分类号： A61K31/4745 ,  C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K38/21 ,  A61K39/395 ,  A61K38/22 ,  A61K31/704 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D471/14 ,  C07D491/14 ,  C07D495/14

摘要： The present invention relates to substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的咪唑基-5,6-二氢苯并[n]异喹啉化合物和合成这些化合物的方法。 本发明还涉及含有取代的咪唑基-5,6-二氢苯并[n]异喹啉化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：US08569331B2

公开(公告)日：2013-10-29

申请号：US13286294

申请日：2011-11-01

申请人： Mark A. Ashwell ,  Sudharshan Eathiraj ,  Anton Filikov ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Rocio Palma ,  David Vensel ,  Shin Iimura ,  Akiko Shiina ,  Kenichi Yoshida ,  Takanori Yamazaki ,  Akihisa Matsuda

发明人： Mark A. Ashwell ,  Sudharshan Eathiraj ,  Anton Filikov ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Rocio Palma ,  David Vensel ,  Shin Iimura ,  Akiko Shiina ,  Kenichi Yoshida ,  Takanori Yamazaki ,  Akihisa Matsuda

IPC分类号： A61K31/44

CPC分类号： C07D471/14 ,  A61K31/551 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention relates to substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物和合成这些化合物的方法。 本发明还涉及含有取代的苯并[f]咪唑并[1,2-d]吡啶并[2,3-b] [1,4]二氮杂化合物的药物组合物和治疗细胞增殖性疾病如癌症的方法， 将这些化合物和药物组合物给予需要的受试者。

公开(公告)号：US20120259606A1

公开(公告)日：2012-10-11

申请号：US13096580

申请日：2011-04-28

申请人： Mark A. Ashwell ,  Rocio Palma ,  Sudharshan Eathiraj

发明人： Mark A. Ashwell ,  Rocio Palma ,  Sudharshan Eathiraj

IPC分类号： G06F19/12

CPC分类号： C12N9/12 ,  C12Y207/10001

摘要： The present invention provides a c-Met inhibition model. The invention further provides a method to derive inhibition models for other kinases. The kinase inhibition models of the present invention can be used to design or screen for inhibitors for kinases.

摘要翻译： 本发明提供了c-Met抑制模型。 本发明还提供一种导出其他激酶抑制模型的方法。 本发明的激酶抑制模型可用于设计或筛选激酶抑制剂。

公开(公告)号：US07960134B1

公开(公告)日：2011-06-14

申请号：US12221440

申请日：2008-07-31

申请人： Mark A. Ashwell ,  Rocio Palma ,  Sudharshan Eathiraj

发明人： Mark A. Ashwell ,  Rocio Palma ,  Sudharshan Eathiraj

IPC分类号： C12Q1/48 ,  G06F19/00

CPC分类号： C12N9/12 ,  C12Y207/10001

摘要： The present invention provides a c-Met inhibition model. The invention further provides a method to derive inhibition models for other kinases. The kinase inhibition models of the present invention can be used to design or screen for inhibitors for kinases.

公开(公告)号：US20100249115A1

公开(公告)日：2010-09-30

申请号：US12751238

申请日：2010-03-31

申请人： Robert Nicewonger ,  Audra Dalton ,  Chris Brassard ,  Mark A. Ashwell ,  Rocio Palma

发明人： Robert Nicewonger ,  Audra Dalton ,  Chris Brassard ,  Mark A. Ashwell ,  Rocio Palma

IPC分类号： A61K31/5513 ,  A61P35/00 ,  C07D243/14 ,  C07D473/16 ,  A61K31/52

CPC分类号： C07D473/26 ,  C07D487/04

摘要： The present invention relates to substituted heterocyclic compounds and substituted tetrahydroisoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzodiazepine compounds and substituted tetrahydroisoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及取代的杂环化合物和取代的四氢异喹啉化合物及其合成方法。 本发明还涉及含有取代的苯并二氮杂化合物和取代的四氢异喹啉化合物的药物组合物以及通过将这些化合物或药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：US08609688B2

公开(公告)日：2013-12-17

申请号：US13529459

申请日：2012-06-21

申请人： Mark A. Ashwell ,  Chris Brassard ,  Anton Filikov ,  Jason Hill ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Nivedita Namdev ,  Robert Nicewonger ,  Rocio Palma ,  Manish Tandon ,  David Vensel ,  Akihisa Matsuda ,  Shin Iimura ,  Kenichi Yoshida ,  Takanori Yamazaki ,  Takahiro Kitamura ,  Takeshi Isoyama

发明人： Mark A. Ashwell ,  Chris Brassard ,  Anton Filikov ,  Jason Hill ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Nivedita Namdev ,  Robert Nicewonger ,  Rocio Palma ,  Manish Tandon ,  David Vensel ,  Akihisa Matsuda ,  Shin Iimura ,  Kenichi Yoshida ,  Takanori Yamazaki ,  Takahiro Kitamura ,  Takeshi Isoyama

IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D515/02

CPC分类号： C07D471/04 ,  C07D451/02 ,  C07D491/08 ,  C07D498/08

摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

公开(公告)号：US08501770B2

公开(公告)日：2013-08-06

申请号：US12981127

申请日：2010-12-29

申请人： Mark A. Ashwell ,  Chris Brassard ,  Anton Filikov ,  Jason Hill ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Nivedita Namdev ,  Robert Nicewonger ,  Rocio Palma ,  Manish Tandon ,  David Vensel ,  Akihisa Matsuda ,  Shin Iimura ,  Yuko Yamamoto

发明人： Mark A. Ashwell ,  Chris Brassard ,  Anton Filikov ,  Jason Hill ,  Steffi Koerner ,  Jean-Marc Lapierre ,  Yanbin Liu ,  Nivedita Namdev ,  Robert Nicewonger ,  Rocio Palma ,  Manish Tandon ,  David Vensel ,  Akihisa Matsuda ,  Shin Iimura ,  Yuko Yamamoto

IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02

CPC分类号： C07D471/04

摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl-aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.