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    Antibacterial fab i inhibitors
    7.
    发明申请
    Antibacterial fab i inhibitors 审中-公开
    抗菌fab i抑制剂

    公开(公告)号：US20070027190A1

    公开(公告)日：2007-02-01

    申请号：US10542351

    申请日：2004-01-16

    申请人： Donald Moir ,  Yibin Xiang ,  Anthony Arvanites ,  Syed Ali ,  Bolin Geng ,  Mark Ashwell ,  Hernan Orgueira ,  Alan Kaplan

    发明人： Donald Moir ,  Yibin Xiang ,  Anthony Arvanites ,  Syed Ali ,  Bolin Geng ,  Mark Ashwell ,  Hernan Orgueira ,  Alan Kaplan

    IPC分类号： A61K31/4439 ,  A61K31/4436 ,  A61K31/4412

    CPC分类号： C07D405/04 ,  A61K31/44 ,  C07D213/85 ,  C07D409/04 ,  C07D409/14 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481

    摘要： Disclosed herein are antibacterial compounds that inhibit fabl, a NADH-dependent enoyl [acyl carrier protein] reductase enzyme in the fatty acid biosynthesis pathway. The compounds are represented by structural formulas Ia and Ib: R1 and R2 are independently monocyclic aryl or heteroaryl groups, wherein the groups represented by R1 and R2 are optionally substituted with one or more acyclic substituents; R3 is —H or an optionally substituted C1-C8 aliphatic, C3-C8 cycloaliphatic, aryl, or heteroaryl group. X1 is a bond or a C1-C3 alkylene chain that is optionally substituted with a C1-C4 alkyl or an acidic group. X2 is an aryl, heteroaryl or C3-C8 cycloaliphatic ring, wherein the group represented by X2 is optionally substituted with triazole, tetrazole, and/or one or more acyclic substituents.

    摘要翻译： 本文公开了抑制脂肪酸生物合成途径中的fab1，NADH依赖性烯酰基[酰基载体蛋白]还原酶的抗菌化合物。 化合物由结构式Ia和Ib表示：R 1和R 2独立地为单环芳基或杂芳基，其中由R 1和R 2表示的基团任选被一个或多个无环取代基取代; R3是-H或任选取代的C 1 -C 8脂族，C 3 -C 8脂环族，芳基或杂芳基。 X1是任选被C 1 -C 4烷基或酸性基团取代的键或C1-C3亚烷基链。 X 2是芳基，杂芳基或C 3 -C 8脂环族环，其中由X 2表示的基团任选被三唑，四唑和/或一个或多个无环取代基取代。

    Substituted 4-(Indazol-3-yl)phenols
    8.
    发明申请
    Substituted 4-(Indazol-3-yl)phenols 审中-公开
    取代的4-（吲唑-3-基）苯酚

    公开(公告)号：US20070225349A1

    公开(公告)日：2007-09-27

    申请号：US11749494

    申请日：2007-05-16

    申请人： Robert Steffan ,  Edward Matelan ,  Mark Ashwell ,  William Solvibile

    发明人： Robert Steffan ,  Edward Matelan ,  Mark Ashwell ,  William Solvibile

    IPC分类号： A61K31/415 ,  C07D231/00

    CPC分类号： C07D231/56 ,  C07D409/04

    摘要： This invention provides compound of formulae I or II having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

    摘要翻译： 本发明提供具有以下结构的式I或II的化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9， SUB＆gt;和R 10＆gt;如说明书中所定义或其药学上可接受的盐，其可用于治疗疾病的炎性成分，并且特别可用于治疗动脉粥样硬化，心肌梗塞，充血性心脏 失败，炎症性肠病，关节炎，II型糖尿病和自身免疫疾病如多发性硬化和风湿性关节炎。