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    Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    11.
    发明授权
    Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes 失效
    级联聚合物复合物，其制备方法和含有所述复合物的药剂

    公开(公告)号：US5874061A

    公开(公告)日：1999-02-23

    申请号：US777666

    申请日：1996-12-20

    申请人： Heribert Schmitt-Willich ,  Johannes Platzek ,  Bernd Raduchel ,  Hanns-Joachim Weinmann ,  Wolfgang Ebert ,  Bernd Misselwitz ,  Andreas Muhler ,  Thomas Frenzel

    发明人： Heribert Schmitt-Willich ,  Johannes Platzek ,  Bernd Raduchel ,  Hanns-Joachim Weinmann ,  Wolfgang Ebert ,  Bernd Misselwitz ,  Andreas Muhler ,  Thomas Frenzel

    IPC分类号： A61K49/04 ,  A61K49/08 ,  A61B5/055 ,  C07D225/00 ,  C07F5/00 ,  C08F283/00

    CPC分类号： A61K49/124 ,  A61K49/04 ,  A61K51/065

    摘要： Cascade polymer complexes that containa) complexing ligands of general formula IA--{X--�Y--(Z--(W--K.sub.w).sub.z).sub.y!.sub.x }.sub.a, (I) in whichA stands for a nitrogen-containing cascade nucleus of base multiplicity a,X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y,Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w,K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.64 holds true for the product of the multiplicities, and that at least one of cascade reproduction units X, Y, Z, W stands for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane reproduction unit,b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83,c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well asd) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.

    摘要翻译： 含有a）通式IA- {X- [Y-（Z-（W-Kw）z）y] x} a，（I）的络合配体的级联聚合物络合物，其中A代表含氮级联核 基本多重性a，X和Y彼此独立地代表再现多重性x或y，Z和W的直接键合或级联再现单元，彼此独立地代表再现倍数z的级联再现单位 或w，K表示络合剂的基团，代表数字2至12，x，y，z和w彼此独立地代表数字1至4，条件是至少两个再现单位不同 ，多重性的乘积为16，并且级联再现单位X，Y，Z，W中的至少一个代表1,4,7,10-四氮杂环十二烷或1 ，4,8,11-四氮杂环十四烷再生单元，b）原子序数为20至29,39,42,44或57-83的元素的至少16个离子，c）任选的Inor阳离子 甘氨酸和/或有机碱，氨基酸或氨基酸酰胺以及d）任选地酰化的末端氨基是用于诊断和治疗的有价值的化合物。

    Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    13.
    发明授权
    Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes 失效
    级联聚合物复合物，其制备方法和含有所述复合物的药剂

    公开(公告)号：US06248306B1

    公开(公告)日：2001-06-19

    申请号：US08485558

    申请日：1995-06-06

    申请人： Heribert Schmitt-Willich ,  Johannes Platzek ,  Ulrich Niedballa ,  Bernd Raduchel ,  Andreas Muhler ,  Thomas Frenzel ,  Wolfgang Ebert

    发明人： Heribert Schmitt-Willich ,  Johannes Platzek ,  Ulrich Niedballa ,  Bernd Raduchel ,  Andreas Muhler ,  Thomas Frenzel ,  Wolfgang Ebert

    IPC分类号： A61K5100

    CPC分类号： A61K49/04 ,  A61K38/00 ,  A61K49/085 ,  A61K49/124 ,  C07C237/12 ,  C07C271/22 ,  C07D251/64 ,  C07D257/02 ,  C07K5/0215 ,  Y10S424/16

    摘要： Cascade polymer complexes containing a) complexing ligands of general formula I A—{X—[Y—(Z—( W—Kw)z)y]x}a  (I)  in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different and that 16≦a·x·y·z·w≦64 holds true for the product of the multiplicities, b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83 and c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are valuable compounds for diagnosis and therapy.

    摘要翻译： 含有a）的共价聚合物配合物其中A代表碱基多重性a的含氮级联核，X和Y彼此独立地代表通式I的络合配体，代表了直接键合或级联再生单位的繁殖倍数x或 y，z和w彼此独立地代表再现倍数z或w的级联再现单位，K表示络合剂的基团，a表示数字2至12，x，y，z和w， 彼此独立地代表数字1至4，条件是至少两个再现单位不同，并且对于多重性的乘积是真实的，b）原子序数20至29,39,42的元素的至少16个离子 ，44或57-83和c）任选的无机和/或有机碱，氨基酸或氨基酸酰胺的阳离子是用于诊断和治疗的有价值的化合物。

    Contrast agents for image enhancement in magnetic resonance imaging
    15.
    发明授权
    Contrast agents for image enhancement in magnetic resonance imaging 失效
    磁共振成像中图像增强的对比剂

    公开(公告)号：US6146615A

    公开(公告)日：2000-11-14

    申请号：US227962

    申请日：1999-01-11

    申请人： Julian A. Davies ,  Wolfgang Ebert ,  Bernd Raduechel

    发明人： Julian A. Davies ,  Wolfgang Ebert ,  Bernd Raduechel

    IPC分类号： A61K49/10 ,  A61B5/055

    CPC分类号： A61K49/101 ,  Y10S514/836

    摘要： A compound of formula (I): ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R.sup.1, R.sup.2 and R.sup.3, R.sup.4 are ring residues. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue, and a method of administering the second sphere contrast agent.

    摘要翻译： 式（I）化合物：其中，R 1，R 2，R 3和R 4独立地选自氢，烷基和被一个或多个-O-原子取代的烷基，或其中R 1，R 2和R 3，R 4为环残基。 该化合物能够用作配体并与顺磁性Fe（III）离子络合，用作组织磁共振成像的第二球对比增强剂，以及施用第二球形造影剂的方法。

    Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging
    16.
    发明授权
    Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging 失效
    铁（III）配合物作为磁共振成像中图像增强的造影剂

    公开(公告)号：US06294152B1

    公开(公告)日：2001-09-25

    申请号：US09227961

    申请日：1999-01-11

    申请人： Julian A. Davies ,  Wolfgang Ebert ,  Bernd Raduechel ,  Heribert Schmitt-Willich

    发明人： Julian A. Davies ,  Wolfgang Ebert ,  Bernd Raduechel ,  Heribert Schmitt-Willich

    IPC分类号： A61B5055

    CPC分类号： A61K49/101

    摘要： A compound of formula (I): wherein, R1 is independently selected from methyl and ethyl and R2 is independently selected from hydrogen, alkyl, and substituted alkyl. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue. The present invention also relates to a method of administering the second sphere contrast agent.

    摘要翻译： 式（I）化合物：其中，R 1独立地选自甲基和乙基，R 2独立地选自氢，烷基和取代的烷基。 该化合物能够作为配体并与顺磁性Fe（III）离子络合，用作组织磁共振成像的第二球对比增强剂。 本发明还涉及施用第二球形造影剂的方法。