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公开(公告)号：US08019416B2
公开(公告)日：2011-09-13
申请号：US11615383
申请日：2006-12-22
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36564 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.
摘要翻译： 用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。
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公开(公告)号：US20080114407A1
公开(公告)日：2008-05-15
申请号：US11615383
申请日：2006-12-22
IPC分类号： A61N1/05
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36564 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.
摘要翻译： 用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。
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公开(公告)号：US20110319955A1
公开(公告)日：2011-12-29
申请号：US13229948
申请日：2011-09-12
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36564 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.
摘要翻译： 用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。 通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式 。 取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。
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14.发明授权Method and apparatus for delivering chronic and post-ischemia cardiac therapies 失效用于递送慢性和缺血后心脏治疗的方法和装置公开(公告)号：US07668594B2
公开(公告)日：2010-02-23
申请号：US11207251
申请日：2005-08-19
申请人： Marina Brockway , Joseph M. Pastore , Yi Zhang , Carlos Ricci , Allan Shuros , Rodney W. Salo
发明人： Marina Brockway , Joseph M. Pastore , Yi Zhang , Carlos Ricci , Allan Shuros , Rodney W. Salo
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/36114 , A61N1/3627 , A61N1/36521 , A61N1/36557
摘要： An implantable cardiac rhythm management (CRM) device delivers a chronic therapy while detecting an ischemic state. When the ischemic state indicates the occurrence of an ischemic event, the implantable CRM device delivers a post-ischemia therapy. The post-ischemia therapy and the chronic therapy are adjusted using feedback control with the ischemic state and parameters indicative of the effectiveness of the post-ischemic therapy and the effectiveness of the chronic therapy as inputs.
摘要翻译： 植入式心律管理（CRM）装置在检测缺血状态时进行慢性治疗。 当缺血状态表明发生缺血事件时，可植入的CRM装置传递缺血后的治疗。 使用具有缺血状态的反馈控制和指示缺血后治疗的有效性和作为输入的慢性治疗的有效性的参数来调整局部后缺血治疗和慢性治疗。
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15.发明申请METHOD AND APPARATUS FOR DELIVERING CHRONIC AND POST-ISCHEMIA CARDIAC THERAPIES 有权用于输送慢性和后期心脏病治疗的方法和装置公开(公告)号：US20100121391A1
公开(公告)日：2010-05-13
申请号：US12689016
申请日：2010-01-18
申请人： Marina Brockway , Joseph M. Pastore , Yi Zhang , Carlos Ricci , Allan Shuros , Rodney W. Salo
发明人： Marina Brockway , Joseph M. Pastore , Yi Zhang , Carlos Ricci , Allan Shuros , Rodney W. Salo
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/36114 , A61N1/3627 , A61N1/36521 , A61N1/36557
摘要： An implantable cardiac rhythm management (CRM) device delivers a chronic therapy while detecting an ischemic state. When the ischemic state indicates the occurrence of an ischemic event, the implantable CRM device delivers a post-ischemia therapy. The post-ischemia therapy and the chronic therapy are adjusted using feedback control with the ischemic state and parameters indicative of the effectiveness of the post-ischemic therapy and the effectiveness of the chronic therapy as inputs.
摘要翻译： 植入式心律管理（CRM）装置在检测缺血状态时进行慢性治疗。 当缺血状态表明发生缺血事件时，可植入的CRM装置传递缺血后的治疗。 使用具有缺血状态的反馈控制和指示缺血后治疗的有效性和作为输入的慢性治疗的有效性的参数来调整局部后缺血治疗和慢性治疗。
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16.发明申请公开(公告)号：US20090069855A1
公开(公告)日：2009-03-12
申请号：US12268170
申请日：2008-11-10
申请人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
发明人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.
摘要翻译： 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗塞后重建。
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17.发明授权公开(公告)号：US08121684B2
公开(公告)日：2012-02-21
申请号：US12268170
申请日：2008-11-10
申请人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
发明人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61N1/05
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.
摘要翻译： 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗死后重塑。
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18.发明授权公开(公告)号：US07450988B2
公开(公告)日：2008-11-11
申请号：US10862011
申请日：2004-06-04
申请人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
发明人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.
摘要翻译： 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗死后重塑。
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公开(公告)号：US20120041504A1
公开(公告)日：2012-02-16
申请号：US13279493
申请日：2011-10-24
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译： 用电刺激治疗逆转心室重构的装置。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。
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公开(公告)号：US08046066B2
公开(公告)日：2011-10-25
申请号：US12484882
申请日：2009-06-15
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译： 用电刺激治疗逆转心室重构的装置。 通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。 随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。
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