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    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
    2.
    发明申请
    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure 有权
    在缺血后或心力衰竭期间调节细胞代谢的方法和装置

    公开(公告)号：US20080091138A1

    公开(公告)日：2008-04-17

    申请号：US11998969

    申请日：2007-12-03

    申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

    发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

    IPC分类号： A61M31/00

    CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

    摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

    摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

    Drug eluting implants to prevent cardiac apoptosis
    8.
    发明申请
    Drug eluting implants to prevent cardiac apoptosis 审中-公开
    药物洗脱植入物以预防心脏细胞凋亡

    公开(公告)号：US20050267556A1

    公开(公告)日：2005-12-01

    申请号：US10856201

    申请日：2004-05-28

    申请人： Allan Shuros ,  Avram Scheiner ,  Rodney Salo

    发明人： Allan Shuros ,  Avram Scheiner ,  Rodney Salo

    IPC分类号： A61L31/16 ,  A61N1/05 ,  A61K9/22 ,  A61N1/362

    CPC分类号： A61L31/16 ,  A61L2300/40 ,  D04C1/06 ,  D10B2509/00

    摘要： Implantable devices are configured to be positioned in or near the heart and to carry and deliver an anti-apoptotic drug to a treatment site in or near the heart. The implantable devices include, but are not limited to, leads, stents, heart valves, atrial septal defect devices, cardiac patches and ventricular restraint devices. Depending on the composition of the device, the drug may be carried by the device through a coating applied to the device, or may be included in the device during the device manufacturing process. The drug may also be included in microparticles, such a microspheres, that are delivered locally through a conduit, such as a catheter.

    摘要翻译： 可植入装置被配置为定位在心脏中或附近，并将抗细胞凋亡药物携带并递送至心脏内或附近的治疗部位。 可植入装置包括但不限于引线，支架，心脏瓣膜，心房间隔缺损装置，心脏贴片和心室约束装置。 根据装置的组成，药物可以由装置通过施加到装置的涂层携带，或者可以在装置制造过程中包括在装置中。 药物也可以包括在通过导管（例如导管）局部递送的微粒（例如微球体）中。

    Implantable physiologic monitoring system
    9.
    发明申请
    Implantable physiologic monitoring system 审中-公开
    植入式生理监测系统

    公开(公告)号：US20070088214A1

    公开(公告)日：2007-04-19

    申请号：US11250928

    申请日：2005-10-14

    申请人： Allan Shuros ,  Rodney Salo ,  Michael Kane

    发明人： Allan Shuros ,  Rodney Salo ,  Michael Kane

    IPC分类号： A61B8/00

    CPC分类号： A61B8/065 ,  A61B5/076 ,  A61B5/1076 ,  A61B5/6876 ,  A61B5/6884 ,  A61B8/02 ,  A61B8/06 ,  A61B8/12 ,  A61B8/4483

    摘要： An ultrasonic implantable device includes an ultrasonic sensor having a plurality of transducers. The sensor is configured for mounting to a vessel wall. A first of the transducers directs sound waves in a direction at least partially upstream or downstream in the vessel. A second of the transducers directs sound waves in a radial direction through an interior of the vessel against a sidewall of the vessel. The sensor monitors a change in frequency of the sound waves from the first transducer to determine a fluid velocity in the vessel. The sensor also monitors a reflection time of the sound waves from the second transducer that return from the sidewall to determine an internal diameter of the vessel. The determined fluid velocity and vessel diameter can be used to determine a volumetric flow rate of the fluid in the vessel.

    摘要翻译： 超声波可植入装置包括具有多个换能器的超声波传感器。 传感器被配置为安装到血管壁。 换能器中的第一个将声波沿至少部分在容器的上游或下游的方向引导。 传感器中的第二个将声波沿径向引导通过容器的内部抵靠容器的侧壁。 传感器监测来自第一换能器的声波的频率变化以确定容器中的流体速度。 传感器还监测来自第二换能器的声波的反射时间，其从侧壁返回以确定容器的内径。 确定的流体速度和容器直径可用于确定容器中流体的体积流量。