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公开(公告)号：US08410133B2
公开(公告)日：2013-04-02
申请号：US12792044
申请日：2010-06-02
申请人： Juan-Miguel Jimenez , Philip Collier , Jeremy Green , Gregory Henkel , Michael Liu , Timothy Neuberger
发明人： Juan-Miguel Jimenez , Philip Collier , Jeremy Green , Gregory Henkel , Michael Liu , Timothy Neuberger
IPC分类号： C07D513/02 , C07D515/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K45/06 , C07D417/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds, the methods of using the aforementioned compounds, and compounds in the treatment of various diseases, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含那些化合物的药学上可接受的组合物，使用上述化合物的方法和化合物治疗各种疾病，病症和障碍。 本发明还提供了制备本发明化合物的方法。
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![PROCESS FOR PREPARING 5-FLUORO-1H-PYRAZOLO [3,4-B] PYRIDIN-3-AMINE AND DERIVATIVES THEREOF](/abs-image/US/2012/09/13/US20120232275A1/abs.jpg.150x150.jpg)
12.发明申请PROCESS FOR PREPARING 5-FLUORO-1H-PYRAZOLO [3,4-B] PYRIDIN-3-AMINE AND DERIVATIVES THEREOF 失效制备5-氟-L-吡唑并[3,4-B]吡啶-3-胺及其衍生物的方法公开(公告)号：US20120232275A1
公开(公告)日：2012-09-13
申请号：US13347926
申请日：2012-01-11
申请人： Juan-Miguel Jimenez , Philip Collier , Jeremy Green , Andrew Miller , Huai Gao , Sylvain Loic Jean-Luc Hamon , Albert Cornelis Dros
发明人： Juan-Miguel Jimenez , Philip Collier , Jeremy Green , Andrew Miller , Huai Gao , Sylvain Loic Jean-Luc Hamon , Albert Cornelis Dros
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
摘要翻译： 本发明涉及以高产率和纯度合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。 本发明还涉及5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的合成方法。 这些方法可用于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。
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公开(公告)号：US20110021559A1
公开(公告)日：2011-01-27
申请号：US12792044
申请日：2010-06-02
申请人： Juan-Miguel Jimenez , Philip Collier , Jeremy Green , Gregory Henkel , Michael Liu , Timothy Neuberger
发明人： Juan-Miguel Jimenez , Philip Collier , Jeremy Green , Gregory Henkel , Michael Liu , Timothy Neuberger
IPC分类号： A61K31/444 , C07D471/04 , C07D417/12 , A61K31/454 , C12N5/071 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P25/00 , A61P9/00 , A61P3/10 , A61P37/04 , A61P25/28 , A61P19/10 , A61P25/16 , A61P25/18 , A61P19/02 , C12N5/0793
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K45/06 , C07D417/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08426425B2
公开(公告)日：2013-04-23
申请号：US12486235
申请日：2009-06-17
IPC分类号： C07D403/14 , C07D471/04 , A61K31/506
CPC分类号： C07D403/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08367697B2
公开(公告)日：2013-02-05
申请号：US13275551
申请日：2011-10-18
申请人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号： C07D513/02 , C07D515/02 , A01N43/42 , A01K31/44
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120178778A1
公开(公告)日：2012-07-12
申请号：US13289320
申请日：2011-11-04
IPC分类号： A61K31/437 , A61P37/06 , A61P29/00 , A61P35/00 , A61P1/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P3/10 , C07D471/04 , A61P11/06
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08173635B2
公开(公告)日：2012-05-08
申请号：US12262459
申请日：2008-10-31
申请人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号： A61K31/496 , C07D471/04 , A61K31/5377 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20120149680A1
公开(公告)日：2012-06-14
申请号：US13275551
申请日：2011-10-18
申请人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号： A61K31/437 , A61P37/00 , A61P29/00 , A61P35/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P37/06 , A61P35/02 , A61P19/04 , A61K31/496 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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![Process for Preparing 5-Fluoro-1H-Pyrazolo [3,4-b] Pyridin-3-amine and Derivatives Thereof](/abs-image/US/2010/07/22/US20100184980A1/abs.jpg.150x150.jpg)
19.发明申请Process for Preparing 5-Fluoro-1H-Pyrazolo [3,4-b] Pyridin-3-amine and Derivatives Thereof 失效制备5-氟-1H-吡唑并[3,4-b]吡啶-3-胺及其衍生物的方法公开(公告)号：US20100184980A1
公开(公告)日：2010-07-22
申请号：US12695292
申请日：2010-01-28
申请人： Juan-Miguel Jimenez , Philip Collier , Andrew Miller , Jeremy Green , Huai Gao , Sylvain Loïc Jean-Luc Hamon , Albert Cornelis Dros
发明人： Juan-Miguel Jimenez , Philip Collier , Andrew Miller , Jeremy Green , Huai Gao , Sylvain Loïc Jean-Luc Hamon , Albert Cornelis Dros
IPC分类号： C07D401/14 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
摘要翻译： 本发明涉及以高产率和纯度合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。 本发明还涉及5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的合成方法。 这些方法可用于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。
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公开(公告)号：US20090291937A1
公开(公告)日：2009-11-26
申请号：US12262459
申请日：2008-10-31
申请人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
发明人： Juan-Miguel Jimenez , Michael Mortimore , Andrew Miller , Philip Collier , Stephen Young , Guy Brenchley , Chris Davis , Heather Twin , Chau Mak , Dean Boyall , Shazia Keily , Luca Settimo
IPC分类号： A61K31/496 , C07D471/04 , A61K31/5377 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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