公开(公告)号：US20200042512A1

公开(公告)日：2020-02-06

申请号：US15974020

申请日：2018-05-08

Applicant: Stephen Young

Inventor： Stephen Young

IPC: G06F16/23 ,  G06F16/27

Abstract: A method is provided. The method comprises a computer embedding a first database primitive in a first entry of a distributed ledger. The method also comprises the computer embedding a second database primitive in a second entry of the distributed ledger. The method also comprises the computer extracting at least one of the first and second database primitives from the distributed ledger.

公开(公告)号：US08969356B2

公开(公告)日：2015-03-03

申请号：US13106167

申请日：2011-05-12

Applicant: Jean-Damien Charrier ,  Steven John Durrant ,  Ronald Marcellus Alphonsus Knegtel ,  Joanne Pinder ,  Stephen Young ,  Philip Michael Reaper

Inventor： Jean-Damien Charrier ,  Steven John Durrant ,  Ronald Marcellus Alphonsus Knegtel ,  Joanne Pinder ,  Stephen Young ,  Philip Michael Reaper

IPC: A61K31/497 ,  A61K31/4965 ,  C07D241/20 ,  C07D401/06 ,  C07D403/06 ,  C07D409/06 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12

CPC classification number: C07D241/20 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/12 ,  C07D409/06

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的吡嗪和吡啶化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。

公开(公告)号：US08377926B2

公开(公告)日：2013-02-19

申请号：US13020947

申请日：2011-02-04

Applicant: Francois Maltais ,  Guy W. Bemis ,  Tiansheng Wang ,  Juan-Miguel Jimenez ,  Luca Settimo ,  Stephen Young ,  Dean Boyall ,  Damien Fraysse ,  Christopher John Davis

Inventor： Francois Maltais ,  Guy W. Bemis ,  Tiansheng Wang ,  Juan-Miguel Jimenez ,  Luca Settimo ,  Stephen Young ,  Dean Boyall ,  Damien Fraysse ,  Christopher John Davis

IPC: A61K31/44 ,  C07D213/62

CPC classification number: C07D417/14 ,  C07D213/73 ,  C07D213/74 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D407/04 ,  C07D407/12

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：US20120214799A1

公开(公告)日：2012-08-23

申请号：US13442244

申请日：2012-04-09

Applicant: Juan-Miguel Jimenez ,  Guy Bemis ,  Francois Maltais ,  Tiansheng Wang ,  Ronald Knegtel ,  Chris Davis ,  Damien Fraysse ,  Dean Boyall ,  Luca Settimo ,  Stephen Young ,  Michael Mortimore

Inventor： Juan-Miguel Jimenez ,  Guy Bemis ,  Francois Maltais ,  Tiansheng Wang ,  Ronald Knegtel ,  Chris Davis ,  Damien Fraysse ,  Dean Boyall ,  Luca Settimo ,  Stephen Young ,  Michael Mortimore

IPC: A61K31/551 ,  A61P25/28 ,  A61P25/14 ,  A61P25/16 ,  A61P25/00 ,  A61P25/18 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P1/00 ,  A61P35/00 ,  C07D401/06 ,  A61K31/444 ,  C07D401/14 ,  C07D417/14 ,  A61K31/496 ,  C07D409/06 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/497 ,  A61P3/10

CPC classification number: C07D213/73 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D409/14 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D487/08

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

公开(公告)号：US20120136000A1

公开(公告)日：2012-05-31

申请号：US12670989

申请日：2010-01-27

Applicant: Juan-Miguel Jimenez ,  John Studley ,  Ronald Knegtel ,  Luca Settimo ,  Damien Fraysse ,  Philip N. Collier ,  Guy Brenchley ,  Dean Boyall ,  Andrew Miller ,  Heather Twin ,  Stephen Young

Inventor： Juan-Miguel Jimenez ,  John Studley ,  Ronald Knegtel ,  Luca Settimo ,  Damien Fraysse ,  Philip N. Collier ,  Guy Brenchley ,  Dean Boyall ,  Andrew Miller ,  Heather Twin ,  Stephen Young

IPC: A61K31/496 ,  A61K31/497 ,  A61K31/437 ,  A61K31/506 ,  A61P37/00 ,  A61P29/00 ,  A61P35/00 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P3/10 ,  A61P1/00 ,  A61P37/06 ,  A61P35/02 ,  A61P19/04 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/506 ,  C07D239/24 ,  C07D241/10 ,  C07D519/00

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

公开(公告)号：US20120095014A1

公开(公告)日：2012-04-19

申请号：US12595703

申请日：2009-10-13

Applicant: John Studley ,  Stephen Young

Inventor： John Studley ,  Stephen Young

IPC: A61K31/497 ,  A61P35/00 ,  A61P35/02 ,  C07D403/14

CPC classification number: C07D403/14 ,  C07D401/14 ,  C07D471/04

Abstract: The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

Abstract translation: 本发明涉及可用作Aurora蛋白激酶抑制剂的化合物。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该化合物和组合物治疗各种疾病，病症和障碍的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：US20100222318A1

公开(公告)日：2010-09-02

申请号：US12642447

申请日：2009-12-18

Applicant: Jean Damien Charrier ,  Steven Durrant ,  David Kay ,  Ronald Knegtel ,  Somhairle MacCormick ,  Michael Mortimore ,  Michael O'Donnell ,  Joanne Pinder ,  Alistair Rutherford ,  Anisa Nizarali Virani ,  Stephen Young ,  Philip Michael Reaper

Inventor： Jean Damien Charrier ,  Steven Durrant ,  David Kay ,  Ronald Knegtel ,  Somhairle MacCormick ,  Michael Mortimore ,  Michael O'Donnell ,  Joanne Pinder ,  Alistair Rutherford ,  Anisa Nizarali Virani ,  Stephen Young ,  Philip Michael Reaper

IPC: A61K31/497 ,  C12N5/02 ,  C07D413/14 ,  C07D413/04 ,  A61K31/5513 ,  C07D417/04 ,  A61K31/5377 ,  A61K31/553 ,  C07D403/10 ,  A61K35/04

CPC classification number: C07D413/14 ,  A61P35/00 ,  C07D241/28 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的吡嗪化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式I：其中变量如本文所定义。

公开(公告)号：US20100188784A1

公开(公告)日：2010-07-29

申请号：US12358568

申请日：2009-01-23

Applicant: Eric Stephen YOUNG

Inventor： Eric Stephen YOUNG

IPC: H02H9/00

CPC classification number: H02M3/156 ,  H02M3/155

Abstract: Protection circuitry protects a boost converter coupled between input and output nodes for driving a load coupled to the output node. The protection circuitry may comprise a first circuit configured for monitoring a voltage at the output node, the voltage being caused by a signal having a voltage proximate to, or lower than, an input voltage of the boost converter. The protection circuitry may also include a second circuit configured for coupling together the input node with respect to the output node and enabling the boost converter only if the monitored voltage exceeds a reference voltage.

Abstract translation: 保护电路保护耦合在输入和输出节点之间的升压转换器，用于驱动耦合到输出节点的负载。 保护电路可以包括被配置为监视输出节点处的电压的第一电路，该电压由具有接近或低于升压转换器的输入电压的电压的信号引起。 保护电路还可以包括第二电路，其被配置为相对于输出节点将输入节点耦合在一起，并且仅当所监视的电压超过参考电压才启用升压转换器。

公开(公告)号：US08741931B2

公开(公告)日：2014-06-03

申请号：US13442244

申请日：2012-04-09

Applicant: Juan-Miguel Jimenez ,  Guy William Bemis ,  Francois Maltais ,  Tiansheng Wang ,  Ronald Marcellus Alphonsus Knegtel ,  Christopher John Davis ,  Damien Fraysse ,  Dean Boyall ,  Luca Settimo ,  Stephen Young ,  Michael Paul Mortimore

Inventor： Juan-Miguel Jimenez ,  Guy William Bemis ,  Francois Maltais ,  Tiansheng Wang ,  Ronald Marcellus Alphonsus Knegtel ,  Christopher John Davis ,  Damien Fraysse ,  Dean Boyall ,  Luca Settimo ,  Stephen Young ,  Michael Paul Mortimore

IPC: A61K31/444

CPC classification number: C07D213/73 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D409/14 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D487/08

Abstract: The present invention relates to compounds having formula: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及具有下式的化合物：其可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：US08569337B2

公开(公告)日：2013-10-29

申请号：US12670989

申请日：2010-01-27

Applicant: Juan-Miguel Jimenez ,  John Studley ,  Ronald Knegtel ,  Luca Settimo ,  Christopher John Davis ,  Damien Fraysse ,  Philip N. Collier ,  Guy Brenchley ,  Dean Boyall ,  Andrew Miller ,  Heather Twin ,  Stephen Young

Inventor： Juan-Miguel Jimenez ,  John Studley ,  Ronald Knegtel ,  Luca Settimo ,  Christopher John Davis ,  Damien Fraysse ,  Philip N. Collier ,  Guy Brenchley ,  Dean Boyall ,  Andrew Miller ,  Heather Twin ,  Stephen Young

IPC: A61K31/437 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/496 ,  A61K31/506 ,  C07D239/24 ,  C07D241/10 ,  C07D519/00

Abstract: The present invention relates to compounds of tri-cyclic pyrazolopyridine useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions containing such compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的三环吡唑并吡啶化合物。 本发明还提供含有这些化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。