公开(公告)号：US5004833A

公开(公告)日：1991-04-02

申请号：US408192

申请日：1989-09-15

申请人： Toru Yasuzawa ,  Satoshi Nakanishi ,  Chikara Murakata ,  Hiroshi Kase ,  Hiroshi Sano ,  Koji Yamada

发明人： Toru Yasuzawa ,  Satoshi Nakanishi ,  Chikara Murakata ,  Hiroshi Kase ,  Hiroshi Sano ,  Koji Yamada

IPC分类号： C07H15/203

CPC分类号： C07H15/203

摘要： Disclosed are KS-501 derivatives represented by the formula (I) ##STR1## wherein X represents a hydrogen atom or COOR.sub.3, Y represents hydroxy or ##STR2## and R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, provided that when R.sub.1, R.sub.2 and R.sub.3 are simultaneously hydrogen atoms, and when R.sub.1, R.sub.2 and X are simultaneously hydrogen atoms, Y does not represent ##STR3## and a pharmaceutically acceptable acid addition salt thereof. The KS-501 derivatives have a platelet aggregation-inhibiting property, and are expected to be useful as antithrombotic agent.

公开(公告)号：US20070298134A1

公开(公告)日：2007-12-27

申请号：US11794120

申请日：2005-12-28

申请人： Masato Iino ,  Satoshi Yamaki ,  Satoshi Nakanishi ,  Masahiro Tajima ,  Ryuji Ueno

发明人： Masato Iino ,  Satoshi Yamaki ,  Satoshi Nakanishi ,  Masahiro Tajima ,  Ryuji Ueno

IPC分类号： A61K36/534 ,  A61Q5/00 ,  A61Q7/00

CPC分类号： C07D319/06 ,  A61K8/365 ,  A61K8/37 ,  A61K8/4973 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/10 ,  A61Q5/006 ,  A61Q7/00 ,  C07C69/734 ,  C07D317/30

摘要： Provided is a composition for scalp and hair treatment, comprising a menthol derivative and a prostaglandin compound having two hetero atoms at the 15 position. The composition of the present invention is effective not only for preventing dandruff and itchy scalp but also for preventing or treating hair loss, baldness, or hair thinness.

摘要翻译： 本发明提供一种用于头皮和头发处理的组合物，其包含薄荷醇衍生物和在15位具有两个杂原子的前列腺素化合物。 本发明的组合物不仅对防止头皮屑和瘙痒的头皮也有效，而且对于防止或治疗脱发，秃发或毛发变薄是有效的。

公开(公告)号：US5156342A

公开(公告)日：1992-10-20

申请号：US866252

申请日：1992-04-09

申请人： Hideto Takeda ,  Kazuyoshi Sugaya ,  Ryoichi Tada ,  Oyuki Ogawa ,  Hisanori Kobayashi ,  Satoshi Nakanishi

发明人： Hideto Takeda ,  Kazuyoshi Sugaya ,  Ryoichi Tada ,  Oyuki Ogawa ,  Hisanori Kobayashi ,  Satoshi Nakanishi

IPC分类号： F02M51/06 ,  F02M61/06 ,  F02M61/08

CPC分类号： F02M51/0675 ,  F02M51/0678 ,  F02M61/06 ,  F02M61/08

摘要： An electromagnetic fuel injection valve for use in an internal combustion engine includes a valve body provided with a valve seat and a valve member having an abutting part moved within the valve body by an electromagnetic actuator between a closed position where the abutting part abuts against the valve seat to interrupt supply of fuel to the engine and an open position where the abutting portion is spaced from the valve seat to permit supply of the fuel to the engine. The valve member has a metering portion which cooperates with the valve seat to define therebetween a fuel metering gap when the valve member is in the open position. The abutting part of the valve member is located downstream of the metering portion with reference to a flow direction of the fuel so that the metering portion is always immersed in the fuel when the valve member is in the closed position.

公开(公告)号：US5080287A

公开(公告)日：1992-01-14

申请号：US428437

申请日：1989-10-30

申请人： Hideto Takeda ,  Kazuyoshi Sugaya ,  Ryoichi Tada ,  Oyuki Ogawa ,  Hisanori Kobayashi ,  Satoshi Nakanishi

发明人： Hideto Takeda ,  Kazuyoshi Sugaya ,  Ryoichi Tada ,  Oyuki Ogawa ,  Hisanori Kobayashi ,  Satoshi Nakanishi

IPC分类号： F02M51/06 ,  F02M61/06 ,  F02M61/08

CPC分类号： F02M51/0675 ,  F02M51/0678 ,  F02M61/06 ,  F02M61/08

摘要： An electromagnetic fuel injection valve for use in an internal combustion engine includes a valve body provided with a valve seat and a valve member having an abutting part moved within the valve body by an electromagnetic actuator between a closed position where the abutting part abuts against the valve seat to interrupt supply of fuel to the engine and an open position where the abutting portion is spaced from the valve seat to permit supply of the fuel to the engine. The valve member has a metering portion which cooperates with the valve seat to define therebetween a fuel metering gap when the valve member is in the open position. The abutting part of the valve member is located downstream of the metering portion with reference to a flow direction of the fuel so that the metering portion is always immersed in the fuel when the valve member is in the closed position.

摘要翻译： 一种用于内燃机的电磁燃料喷射阀包括一阀体，该阀体设置有阀座和阀构件，该阀体具有一抵靠部件，该抵接部件通过电磁致动器在阀体内移动， 以阻止向发动机供应燃料和打开位置，其中抵接部分与阀座间隔开以允许向发动机供应燃料。 阀构件具有计量部分，其在阀构件处于打开位置时与阀座配合以在其间限定燃料计量间隙。 阀构件的邻接部分相对于燃料的流动方向位于计量部分的下游，使得当阀构件处于关闭位置时，计量部分总是浸入燃料中。

公开(公告)号：US5079232A

公开(公告)日：1992-01-07

申请号：US447891

申请日：1989-12-08

申请人： Keiko Ohsawa ,  Satoshi Nakanishi ,  Hiroshi Kase ,  Isao Kawamoto ,  Tohru Yasuzawa ,  Yutaka Saito ,  Hiroshi Sano ,  Shizuo Shiozaki ,  Katsuichi Shutoh

发明人： Keiko Ohsawa ,  Satoshi Nakanishi ,  Hiroshi Kase ,  Isao Kawamoto ,  Tohru Yasuzawa ,  Yutaka Saito ,  Hiroshi Sano ,  Shizuo Shiozaki ,  Katsuichi Shutoh

IPC分类号： C07H15/26 ,  C12P19/62

CPC分类号： C07H15/26 ,  C12P19/62

摘要： A new compound designated KS-505 having amnesia-inhibiting activity may be prepared by fermentation of a suitable strain of Streptomyces, preferably Streptomyces argenteolus A-2 (FERM BP-2065). The compound is thought to have the structure: ##STR1##

公开(公告)号：US4983775A

公开(公告)日：1991-01-08

申请号：US465893

申请日：1990-01-16

申请人： Satoshi Nakanishi ,  Koji Yamada ,  Katsuhiko Ando ,  Isao Kawamoto ,  Toru Yasuzawa ,  Hiroshi Sano ,  Noriaki Hirayama ,  Hiroshi Kase ,  Joji Goto ,  Etsuyo Shimizu

发明人： Satoshi Nakanishi ,  Koji Yamada ,  Katsuhiko Ando ,  Isao Kawamoto ,  Toru Yasuzawa ,  Hiroshi Sano ,  Noriaki Hirayama ,  Hiroshi Kase ,  Joji Goto ,  Etsuyo Shimizu

IPC分类号： C07C35/48 ,  C07C45/58 ,  C07C47/46 ,  C07D303/48 ,  C12P7/02 ,  C12P7/24 ,  C12P17/02

CPC分类号： C12R1/645 ,  C07C35/48 ,  C07C45/58 ,  C07C47/46 ,  C07D303/48 ,  C12P17/02 ,  C12P7/02 ,  C12P7/24

摘要： Novel physiologically active substances Ks-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

公开(公告)号：US4912132A

公开(公告)日：1990-03-27

申请号：US181702

申请日：1988-04-14

申请人： Satoshi Nakanishi ,  Koji Yamada ,  Katsuhiko Ando ,  Isao Kawamoto ,  Toru Yasuzawa ,  Hiroshi Sano ,  Noriaki Hirayama ,  Hiroshi Kase ,  Joji Goto ,  Etsuyo Shimizu

发明人： Satoshi Nakanishi ,  Koji Yamada ,  Katsuhiko Ando ,  Isao Kawamoto ,  Toru Yasuzawa ,  Hiroshi Sano ,  Noriaki Hirayama ,  Hiroshi Kase ,  Joji Goto ,  Etsuyo Shimizu

IPC分类号： C07C35/48 ,  C07C45/58 ,  C07C47/46 ,  C07D303/48 ,  C12P7/02 ,  C12P7/24 ,  C12P17/02

CPC分类号： C12R1/645 ,  C07C35/48 ,  C07C45/58 ,  C07C47/46 ,  C07D303/48 ,  C12P17/02 ,  C12P7/02 ,  C12P7/24

摘要： Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

公开(公告)号：US4868159A

公开(公告)日：1989-09-19

申请号：US165738

申请日：1988-03-09

申请人： Satoshi Nakanishi ,  Koji Yamada ,  Isao Kawamoto ,  Katsuhiko Ando ,  Hiroshi Sano ,  Toru Yasuzawa ,  Hiroshi Kase

发明人： Satoshi Nakanishi ,  Koji Yamada ,  Isao Kawamoto ,  Katsuhiko Ando ,  Hiroshi Sano ,  Toru Yasuzawa ,  Hiroshi Kase

IPC分类号： C07H15/203 ,  C12P19/44

CPC分类号： C07H15/203 ,  C12P19/44 ,  C12R1/645

摘要： Novel physiologically active substances KS-501 and KS-502 having inhibitory activity on serotonin release from platelets and/or platelet aggregation are produced by culturing a microorganism of the genus Sporothrix.