公开(公告)号：US20190113497A1

公开(公告)日：2019-04-18

申请号：US16207378

申请日：2018-12-03

Applicant: Konica Minolta, Inc.

Inventor： Yasuhiro WATANABE ,  Shuji ICHITANI ,  Kohsuke GONDA ,  Noriaki OHUCHI ,  Mika WATANABE

IPC: G01N33/483 ,  G06T7/00 ,  G06T7/11 ,  G06K9/00 ,  G06T5/50 ,  A61B5/00

Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.

公开(公告)号：US20180136212A1

公开(公告)日：2018-05-17

申请号：US15806970

申请日：2017-11-08

Applicant: Konica Minolta, Inc.

Inventor： Hideki GOUDA ,  Masaru TAKAHASHI ,  Kensaku TAKANASHI ,  Hisatake OKADA ,  Yuichi OZAKI ,  Yuka YOSHIHARA ,  Yasushi NAKANO ,  Kohsuke GONDA ,  Noriaki OHUCHI ,  Mika WATANABE ,  Norikazu MASUDA ,  Masakazu TOI ,  Hiroshi TADA ,  Minoru MIYASHITA

IPC: G01N33/574 ,  G06K9/00

CPC classification number: G01N33/57415 ,  G01N1/30 ,  G01N33/5023 ,  G01N33/582 ,  G01N2333/71 ,  G06K9/00134 ,  G06K9/0014 ,  G06K9/00147

Abstract: The present invention relates to a test support method which is a means for predicting whether or not pathological complete response (pCR) will be attained when a preoperative chemotherapy with an anticancer drug is performed, the method using a sample (breast cancer tissue section) collected from a breast cancer patient to be subjected to the preoperative chemotherapy. The test support method includes: [1] the step of acquiring a fluorescence image of a breast cancer tissue section, which fluorescence image shows bright spots of fluorescent nanoparticles labeling one or more kinds of breast cancer-related proteins; [2] the step of acquiring at least one index relating to the expression level(s) of the breast cancer-related protein(s) on the basis of the bright spots of the fluorescence image; and [3] the step of acquiring information for predicting pCR by performing an analysis using the above-described at least one index.