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公开(公告)号：US20180164277A1
公开(公告)日：2018-06-14
申请号：US15103171
申请日：2014-12-17
Applicant: Konica Minolta, Inc.
Inventor： Yasuhiro WATANABE , Shuji ICHITANI , Kohsuke GONDA , Noriaki OHUCHI , Mika WATANABE
IPC: G01N33/483 , A61B5/00 , G06T5/50 , G06T7/00
CPC classification number: G01N33/4833 , A61B5/0071 , G06K9/0014 , G06T5/50 , G06T7/0012 , G06T7/11 , G06T2207/10064 , G06T2207/20221 , G06T2207/30024
Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.
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公开(公告)号：US20160275673A1
公开(公告)日：2016-09-22
申请号：US14778427
申请日：2014-03-27
Applicant: Konica Minolta, Inc.
Inventor： Shuji ICHITANI , Osamu TOYAMA
CPC classification number: G06K9/00127 , B82Y30/00 , G01N1/30 , G06K9/00134 , G06K9/0014 , G06K9/4604 , G06K9/6215 , G06T7/0012 , G06T2207/10056 , G06T2207/10061 , G06T2207/10064 , G06T2207/20212 , G06T2207/30024
Abstract: An image processing device inputs a bright field linage of a tissue slice in which a cell nucleus is stained and a fluorescent image of the tissue slice in which a specific biological substance is stained with a fluorescent staining reagent (S10), extracts a cell nucleus from the image of the cell nucleus (S20), extracts a fluorescent bright point from the fluorescent image (S30), specifies a cell nucleus to which the fluorescent bright point is assigned on the basis of the distance between the cell nucleus and the fluorescent bright point, and assigns the fluorescent bright point with the cell nucleus (S40).
Abstract translation: 图像处理装置输入细胞核染色的组织切片的亮场线和用荧光染色试剂染色特定生物物质的组织切片的荧光图像（S10），从细胞核提取细胞核 细胞核的图像（S20）从荧光图像提取荧光亮点（S30），根据细胞核与荧光亮点之间的距离，指定赋予荧光亮点的细胞核 ，并将荧光亮点与细胞核分配（S40）。
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Patent Agency Ranking
公开(公告)号：US20190113497A1
公开(公告)日：2019-04-18
申请号：US16207378
申请日：2018-12-03
Applicant: Konica Minolta, Inc.
Inventor： Yasuhiro WATANABE , Shuji ICHITANI , Kohsuke GONDA , Noriaki OHUCHI , Mika WATANABE
Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.
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公开(公告)号：US20170370901A1
公开(公告)日：2017-12-28
申请号：US15533441
申请日：2015-11-30
Applicant: Konica Minolta, Inc.
Inventor： Shuji ICHITANI
IPC: G01N33/483 , G06T7/11 , G01N33/50 , G06T7/00
CPC classification number: G01N33/4833 , G01N33/48 , G01N33/5091 , G06T1/00 , G06T7/00 , G06T7/0016 , G06T7/11 , G06T7/12 , G06T7/174 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024
Abstract: An image processing apparatus contains an input unit to input a fluorescent image and a morphological image of a tissue. A biological substance expressed at a first structure of a cell in the tissue is stained by a fluorescent substance. The fluorescent image illustrates a fluorescent bright point which represents expression of the biological substance. The morphological image illustrates a morphology of a second structure of a cell in the tissue and contains the same range of the tissue as the fluorescent image. The apparatus further contains a feature amount extraction unit to extract a feature amount of the second structure from the morphological image, a bright point extraction unit to extract the fluorescent bright point from the fluorescent image, and a region of interest determination unit to determine a region of interest based on the feature amount of the second structure and a distribution of the fluorescent bright point.
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公开(公告)号：US20190339251A1
公开(公告)日：2019-11-07
申请号：US16515424
申请日：2019-07-18
Applicant: Konica Minolta, Inc.
Inventor： Yasuhiro WATANABE , Shuji ICHITANI , Kohsuke GONDA , Noriaki OHUCHI , Mika WATANABE
Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.
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公开(公告)号：US20180038796A1
公开(公告)日：2018-02-08
申请号：US15551374
申请日：2016-02-08
Applicant: KONICA MINOLTA, INC.
Inventor： Shuji ICHITANI
CPC classification number: G01N21/6458 , G01N21/64 , G01N33/48 , G06T1/00 , G06T7/00 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T7/60 , G06T2207/20036 , G06T2207/20092 , G06T2207/30024 , G06T2207/30096
Abstract: An image processing device prepares an interest image from an image obtained by photographing a cell in a sample and includes a cell image inputting unit, a setting unit, a preparation unit, and a display. The image is input to the image inputting unit. The setting unit sets one or more target images in the image. The preparation unit prepares plural candidate images by performing image processing of each of the one or more target images using one or more prescribed parameters. The display displays the plural candidate images prepared by the preparation unit.
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7.发明申请公开(公告)号：US20150098626A1
公开(公告)日：2015-04-09
申请号：US14568972
申请日：2014-12-12
Applicant: Konica Minolta, Inc.
Inventor： Shuji ICHITANI , Osamu TOYAMA
CPC classification number: G01N11/04 , G01F3/36 , G01N15/1463 , G01N33/49 , G01N2015/1075 , G01N2015/1495 , G06T7/215 , G06T2207/30104
Abstract: Deformability of blood cells is quantified in a short time. A blood fluidity measurement apparatus is provided with a TV camera which photographs a stream of blood in either two areas of the internal area, entrance area, and exit area of a gate, an image processing part which calculates the velocity of the blood cells contained in the blood from the image taken by the TV camera, and a deformability calculation means which calculates the deformability of the blood cells a blood fluidity from the velocity.
Abstract translation: 在短时间内量化血细胞的变形性。 血液流动性测量装置设置有电视摄像机，其对门的内部区域，入口区域和出口区域的两个区域中的血液流进行拍摄，图像处理部分计算包含在血液中的血细胞的速度 来自电视摄像机拍摄的图像的血液，以及根据该速度计算血液细胞变形性的变形能力计算装置。
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