公开(公告)号：US12029607B2

公开(公告)日：2024-07-09

申请号：US17903076

申请日：2022-09-06

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christian Haase ,  Michael Grass

IPC: A61B8/06 ,  A61B5/026 ,  A61B8/00 ,  A61B8/12

CPC classification number: A61B8/06 ,  A61B8/12 ,  A61B8/445 ,  A61B5/026

Abstract: The invention relates to a blood flow determination apparatus (5) comprising a speckle density determination unit (7) for determining a speckle density value being indicative of a level of a speckle density in an ultrasound image of an inner lumen of a blood vessel, which has been generated at an imaging location being behind an introduction location at which a fluid has been introduced into the blood vessel (20) with a known volumetric fluid flow rate. A blood flow rate determination unit (8) determines a blood flow value being indicative of a volumetric blood flow rate based on the determined speckle density value and the volumetric fluid flow rate. This allows determining the intravascular blood flow with an improved accuracy.

公开(公告)号：US11664128B2

公开(公告)日：2023-05-30

申请号：US16647799

申请日：2018-09-12

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christian Haase ,  Holger Schmitt ,  Michael Grass ,  Arjen Van Der Horst

IPC: G06T7/00 ,  G16H50/30 ,  G16H30/40 ,  G06F30/28

CPC classification number: G16H50/30 ,  G06F30/28 ,  G06T7/0012 ,  G16H30/40 ,  G06T2207/10081

Abstract: An apparatus for assessing a patient's vasculature and a corresponding method identify the bifurcations in a vessel of interest on the basis of a local change in at least one geometric parameter value of the vessel of interest and adjust the fluid dynamics inside the vessel of interest to take account for said bifurcations.

公开(公告)号：US11179043B2

公开(公告)日：2021-11-23

申请号：US16338290

申请日：2017-10-02

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christian Haase ,  Michael Grass ,  Bram Antonius Philomena Van Rens ,  Roland Wilhelmus Maria Bullens ,  Peter Maria Johannes Rongen ,  Arjen Van Der Horst ,  Raoul Florent ,  Romane Isabelle Marie-Bernard Gauriau ,  Javier Olivan Bescos ,  Holger Schmitt ,  Vincent Maurice André Auvray

IPC: A61B5/02 ,  G06T7/62 ,  A61B5/021 ,  A61B5/026 ,  A61B5/107 ,  A61B6/00

Abstract: An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface (40) and a processing unit (50). The input interface is configured to obtain image data (30) representing a two-dimensional representation of a vessel (6). The processing unit (50) is configured to determine a course of the vessel (6) and a width (w1, w2) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.

公开(公告)号：US12226245B2

公开(公告)日：2025-02-18

申请号：US18017143

申请日：2021-07-16

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Klaus Alfred Erhard ,  Heiner Daerr ,  Artur Sossin ,  Axel Thran ,  Bernhard Johannes Brendel ,  Christian Haase ,  Claas Bontus

IPC: A61B6/12 ,  A61B6/00

Abstract: A spectral X-ray imaging system (100) includes an X-ray source (110) and an X-ray detector (120) that are mounted to a support structure (150). The support structure (150) is configured to rotate the X-ray source (110) and the X-ray detector (120) around two or more orthogonal axes (A-A′, B-B′). One or more processors (130) are configured to cause the system (100) to perform operations that include: generating a spectral image based on the spectral image data; and identifying, in the spectral image, a position of a first fiducial marker (180i) comprising a first material, based on a first X-ray absorption k-edge energy value (190i) of the first material.

公开(公告)号：US12023189B2

公开(公告)日：2024-07-02

申请号：US17263469

申请日：2019-08-02

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christian Haase ,  Michael Grass ,  Romane Isabelle Marie-Bernard Gauriau ,  Martijn Anne Van Lavieren

IPC: A61B6/50 ,  A61B6/00 ,  G06T7/00 ,  G16H50/20

CPC classification number: A61B6/504 ,  A61B6/481 ,  G06T7/0012 ,  G16H50/20 ,  G06T2207/20081 ,  G06T2207/30104

Abstract: An apparatus for assessing a coronary vasculature and a corresponding method are provided which allow to globally assess a coronary artery disease directly from the contrast agent dynamics as derived from diagnostic images acquired using an invasive medical imaging modality by following the time course of the area occupied by the vessels in the diagnostic images.

公开(公告)号：US11875429B2

公开(公告)日：2024-01-16

申请号：US17040744

申请日：2019-03-18

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christian Haase ,  Michael Grass ,  Dirk Schaefer

IPC: G06T11/00 ,  A61B6/03 ,  A61B6/00 ,  G06T7/00 ,  G06F18/22

CPC classification number: G06T11/005 ,  A61B6/032 ,  A61B6/4028 ,  A61B6/463 ,  A61B6/501 ,  A61B6/5264 ,  A61B6/54 ,  G06F18/22 ,  G06T7/0012 ,  G06T11/008 ,  G06T2207/10081 ,  G06T2207/30008

Abstract: An apparatus for image reconstruction that includes input circuitry configured to acquire, from an image sequence, first and second 2D projection data of a region of interest of an object at respective acquisition times; and provide first 3D object data of a first object in a region of interest and second 3D object data of a second object in a region of interest. The apparatus also includes a processor configured to generate a first registration of the first and/or second 3D object data to the first 2D projection data and a second registration of the first and/or second 3D object data to the second 2D projection data; provide a vector field defining motion of the second object relative to the first object between the acquisition times based on the registrations; generate corrected projection data using the vector field; and generate a motion-compensated image sequence based on the corrected projection data.

公开(公告)号：US11678855B2

公开(公告)日：2023-06-20

申请号：US16645224

申请日：2018-09-06

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christian Haase ,  Michael Grass ,  Martijn Anne Van Lavieren

IPC: A61B6/00 ,  G16H50/50 ,  G16H30/20 ,  G16H50/30 ,  G16H50/20 ,  G16H30/40 ,  A61B5/0215 ,  A61B5/055

CPC classification number: A61B6/5247 ,  A61B5/0215 ,  A61B6/461 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5217 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  A61B5/055 ,  A61B6/481

Abstract: An apparatus for analyzing coronary vessels and a corresponding method are provided in which simulated pullback data obtained from (non-invasively) acquired diagnostic images is co-registered with invasively acquired intravascular pullback data and the co-registration is used to identify disparities in the pullback data obtained using the two modalities. These disparities allow for deriving further information about the vessel geometry and/or the blood flow through the vessel. They may therefore be used to improve the physiological model.

公开(公告)号：US11282170B2

公开(公告)日：2022-03-22

申请号：US16496620

申请日：2018-03-29

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Romane Isabelle Marie-Bernard Gauriau ,  Christian Haase ,  Michael Grass ,  Javier Olivan Bescos ,  Raoul Florent

IPC: G06T3/40 ,  G06T17/00 ,  A61B5/026 ,  A61B6/00

Abstract: Vasculature modeling systems and methods are disclosed that generate an enhanced 3D model based on a combination of two dimensional, 2D, imaging data of a region of interest and 3D imaging data of the region of interest. A hemodynamic simulation is performed using the enhanced 3D model to derive at least one hemodynamic parameter based on the hemodynamic simulation.

公开(公告)号：US11172896B2

公开(公告)日：2021-11-16

申请号：US15551925

申请日：2015-12-04

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Christian Haase ,  Dirk Schaefer ,  Eberhard Sebastian Hansis ,  Tobias Klinder ,  Michael Grass ,  Ming De Lin

IPC: A61B6/00 ,  A61B6/03 ,  A61K49/04 ,  A61M5/00 ,  G16H20/17 ,  G16H30/20

Abstract: The present invention is directed towards a system and method for transarterial chemoembolization using differently sized drug-eluting microsphere beads filled with drugs and determining a delivered drug concentration using an imaging system.

公开(公告)号：US10251594B2

公开(公告)日：2019-04-09

申请号：US15543466

申请日：2016-01-07

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Tobias Klinder ,  Eberhard Sebastian Hansis ,  Michael Grass ,  Dirk Schaefer ,  Hanno Heyke Homann ,  Christian Haase

IPC: A61B5/00 ,  A61B6/00 ,  G06K9/00 ,  G06T7/00 ,  G06T19/00 ,  A61B6/03 ,  A61B6/04 ,  A61B5/055

Abstract: Minimally-invasive spinal inventions are often performed using fluoroscopic imaging methods, which can give a real-time impression of the location of a surgical instrument, at the expense of a small field of view. When operating on a spinal column, a small field of view can be a problem, because a medical professional is left with no reference vertebra in the fluoroscopy image, from which to identify a vertebra, which is the subject of the intervention. Identifying contiguous vertebrae is difficult because such contiguous vertebrae are similar in shape. However, characteristic features, which differentiate one vertebra from other vertebra, and which are visible in the fluoroscopic view, may be used to provide a reference.