公开(公告)号：US20220135559A1

公开(公告)日：2022-05-05

申请号：US17431591

申请日：2020-02-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： TAE BO SIM ,  Woo Young HUR ,  Chi Man SONG ,  Sandip SENGUPTA ,  Chan Sun PARK ,  Seung Hye CHOI ,  Han Na CHO ,  In Jae SHIN

IPC: C07D471/04

Abstract: The present disclosure relates to a pyrido[3,4-d]pyrimidin-8-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anticancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.

公开(公告)号：US20180370922A1

公开(公告)日：2018-12-27

申请号：US16015596

申请日：2018-06-22

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo ROH ,  Karam Mohamed Hasan Fara AHMED ,  So Ra PAIK ,  Woo Young HUR ,  Elkamhawy AHMED

IPC: C07D239/48 ,  C07D413/12 ,  A61P19/02 ,  A61P1/00

Abstract: The present invention relates to a 6-phenoxypyrimidine derivative, a method for preparing the compound and a pharmaceutical composition containing the compound as an active ingredient. Because the 6-phenoxypyrimidine compound represented by Chemical Formula 1 according to the present invention has an activity of inhibiting the production of nitric oxide (NO) as an inflammation-related factor, it is useful in treating and preventing inflammatory diseases including immunological diseases.