公开(公告)号：US20160145240A1

公开(公告)日：2016-05-26

申请号：US14947204

申请日：2015-11-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  Ji Hye YOON ,  Woo Young HUR ,  Eun Joo ROH ,  Yeon Ui KWAK

IPC: C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  C07D401/14

CPC classification number: C07D403/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04

Abstract: A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for preventing and treating a disease caused by abnormal cell growth, which contains the compound as an active ingredient.

Abstract translation: 杂芳基胺化合物包括蛋白激酶抑制活性，其药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其含有该化合物作为活性成分。

公开(公告)号：US20140114067A1

公开(公告)日：2014-04-24

申请号：US14048979

申请日：2013-10-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ae Nim PAE ,  Sun Joon MIN ,  Eun Joo ROH ,  Ha Yun YANG ,  Tae Hoon KIM ,  Beoung Gun PARK ,  Yong Seo CHO

IPC: C07D413/06 ,  C07D403/06 ,  C07D401/06 ,  C07D233/26

CPC classification number: C07D413/06 ,  C07D235/08 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/28 ,  C07D401/06 ,  C07D403/06 ,  C07D403/12

Abstract: Provided are a benzimidazole derivative modulating mitochondrial functions and having pharmaceutical activity as a neuro-protective agent, and a pharmaceutical composition including the compound as an active ingredient.

Abstract translation: 提供调节线粒体功能并具有作为神经保护剂的药物活性的苯并咪唑衍生物和包含该化合物作为活性成分的药物组合物。

公开(公告)号：US20190315726A1

公开(公告)日：2019-10-17

申请号：US16362571

申请日：2019-03-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Ha LEE ,  Kyung Ho YOO ,  Eun Joo ROH ,  Tae Bo SIM ,  Tae Young KIM ,  Jae Ho KIM

IPC: C07D405/14 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/48 ,  A61P35/00 ,  A61P25/28 ,  A61P37/02 ,  A61P29/00

Abstract: Disclosed are a novel pyrimidine derivative compound, a pharmaceutically acceptable salt thereof, a method for preparing the compound and a pharmaceutical use of the compound as an anticancer agent or a therapeutic agent for degenerative brain diseases. Specifically, the novel pyrimidine derivative compound has excellent inhibitory activities against kinase enzymes such as ARK5/NUAK1, ACK1, FLT3, JAK1, JAK2 and JAK2 (V617F) and thus is useful for treating and preventing leukemia, ovarian cancer, breast cancer, non-small cell carcinoma, colorectal cancer, glioma, and brain protein abnormalities such as Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia, that is, degenerative diseases caused by Tau deposition.

公开(公告)号：US20150148550A1

公开(公告)日：2015-05-28

申请号：US14092151

申请日：2013-11-27

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo ROH ,  Changjoon Justin LEE ,  Soo Jin OH ,  Jong Hoon JUNG

IPC: C07D333/40 ,  C07C205/57 ,  C07C63/70 ,  C07C65/03 ,  C07C65/21 ,  C07C205/58 ,  C07C205/59

CPC classification number: C07D333/40 ,  C07C229/56 ,  C07C229/58

Abstract: Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.

Abstract translation: 公开了一种用作钙依赖性氯离子通道阻断剂的新型化合物。

公开(公告)号：US20180370922A1

公开(公告)日：2018-12-27

申请号：US16015596

申请日：2018-06-22

Applicant: Korea Institute of Science and Technology

Inventor： Eun Joo ROH ,  Karam Mohamed Hasan Fara AHMED ,  So Ra PAIK ,  Woo Young HUR ,  Elkamhawy AHMED

IPC: C07D239/48 ,  C07D413/12 ,  A61P19/02 ,  A61P1/00

Abstract: The present invention relates to a 6-phenoxypyrimidine derivative, a method for preparing the compound and a pharmaceutical composition containing the compound as an active ingredient. Because the 6-phenoxypyrimidine compound represented by Chemical Formula 1 according to the present invention has an activity of inhibiting the production of nitric oxide (NO) as an inflammation-related factor, it is useful in treating and preventing inflammatory diseases including immunological diseases.