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公开(公告)号：US5863896A
公开(公告)日：1999-01-26
申请号：US555423
申请日：1995-11-09
申请人： Jan Rosing , Guido Tans , Katalin Varadi , Hans Peter Schwarz
发明人： Jan Rosing , Guido Tans , Katalin Varadi , Hans Peter Schwarz
CPC分类号： G01N33/86 , A61K38/36 , C12Q1/56 , G01N2333/745 , G01N2333/96461 , G01N2333/96463 , G01N2405/04
摘要： The present invention provides methods, reagents, and test kits for evaluating the effect of a test composition on APC response by employing factor Va.sup.R506Q Methods and compositions for treating patients suffering from reduced APC response are also provided.
摘要翻译： 本发明提供了通过使用因子VaR506Q来评估测试组合物对APC反应的影响的方法，试剂和测试试剂盒。还提供了用于治疗患有APC反应降低的患者的组合物。
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12.发明授权
公开(公告)号：US5804181A
公开(公告)日：1998-09-08
申请号：US452169
申请日：1995-05-26
申请人： Johann Eibl , Hans Peter Schwarz , Katalin Varadi
发明人： Johann Eibl , Hans Peter Schwarz , Katalin Varadi
CPC分类号： A61K38/36 , A61K38/482
摘要： A pharmaceutical preparation for the prevention and treatment of blood coagulation disorders is described which is characterized in that it comprises Factor V as a native protein, derivative and/or fragment thereof and Protein S in suitable pharmaceutical carrier.
摘要翻译： 描述了用于预防和治疗凝血障碍的药物制剂，其特征在于其包含作为天然蛋白质的因子V，其衍生物和/或片段以及合适的药物载体中的蛋白S。
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公开(公告)号：US5643739A
公开(公告)日：1997-07-01
申请号：US432018
申请日：1995-05-01
申请人： Katalin Varadi , Hans Peter Schwarz , Hartmut Lang , Berta Moritz
发明人： Katalin Varadi , Hans Peter Schwarz , Hartmut Lang , Berta Moritz
CPC分类号： C12Q1/56 , G01N2333/96444 , G01N2333/9645 , G01N2333/96461 , G01N2333/974 , G01N2405/04 , Y10S435/81 , Y10S436/808 , Y10S514/834
摘要： An improved assay for determining sensitivity to activated protein C in test samples has been developed to ensure rapid and accurate evaluations. This assay is based on measuring the conversion, by activated factor VIII within a test sample, of added factor X to an activated form. The activated protein C sensitivity of the test sample is determined by the relative inhibition of factor X conversion as compared to a control. A test sample that has decreased sensitivity to activated protein C will show relatively low inhibition, and vice versa.
摘要翻译： 已经开发了用于确定测试样品中对活化蛋白C的敏感性的改进测定法，以确保快速和准确的评估。 该测定法是基于测试样品中活化因子VIII的转化，将添加的因子X转化为活化形式。 与对照相比，测试样品的活化蛋白C敏感性由因子X转化的相对抑制决定。 对活化蛋白C的敏感性降低的测试样品将显示相对较低的抑制作用，反之亦然。
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14.发明授权Von willebrand factor- and factor VIII-polymer conjugates having a releasable linkage 有权具有释放键的冯维勒布兰因子和因子VIII-聚合物共轭物公开(公告)号：US09493544B2
公开(公告)日：2016-11-15
申请号：US13620285
申请日：2012-09-14
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08 , A61K47/48
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译： 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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公开(公告)号：US20100168391A1
公开(公告)日：2010-07-01
申请号：US12719265
申请日：2010-03-08
IPC分类号： C07K14/755
CPC分类号： C07K14/755 , A61K47/60 , C07K14/745
摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。
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公开(公告)号：US20070244301A1
公开(公告)日：2007-10-18
申请号：US11729625
申请日：2007-03-29
IPC分类号： C07K14/745
CPC分类号： C07K14/755 , A61K47/60 , C07K14/745
摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。
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17.发明授权Method and compositions for specifically detecting physiologically acceptable polymer molecules 有权专门检测生理上可接受的聚合物分子的方法和组合物公开(公告)号：US08557534B2
公开(公告)日：2013-10-15
申请号：US12342405
申请日：2008-12-23
申请人： Peter Turecek , Juergen Siekmann , Alfred Weber , Herbert Gritsch , Katalin Varadi , Susanne Vejda
发明人： Peter Turecek , Juergen Siekmann , Alfred Weber , Herbert Gritsch , Katalin Varadi , Susanne Vejda
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
摘要： The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.
摘要翻译： 本发明涉及一种用于测定与蛋白质结合的生理学上可接受的聚合物分子的量的方法，能够特异性结合生理上可接受的聚合物分子的抗体或其它组合物，以及含有所述抗体或组合物的试剂盒。
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18.发明授权Von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage 有权Von Willebrand因子和因子VIII-聚合物缀合物具有可释放的连接公开(公告)号：US08349800B2
公开(公告)日：2013-01-08
申请号：US13371275
申请日：2012-02-10
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译： 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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19.发明申请Von Willebrand Factor- and Factor VIII-Polymer Conjugates Having a Releasable Linkage 有权Von Willebrand因子和因子VIII-聚合物缀合物具有可释放的连接公开(公告)号：US20120142594A1
公开(公告)日：2012-06-07
申请号：US13371275
申请日：2012-02-10
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译： 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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公开(公告)号：US08053561B2
公开(公告)日：2011-11-08
申请号：US12719265
申请日：2010-03-08
IPC分类号： A61K38/00 , A61K38/37 , C07K14/435 , C07K14/755
CPC分类号： C07K14/755 , A61K47/60 , C07K14/745
摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。
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