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1.发明授权Method and compositions for specifically detecting physiologically acceptable polymer molecules 有权专门检测生理上可接受的聚合物分子的方法和组合物公开(公告)号：US08557534B2
公开(公告)日：2013-10-15
申请号：US12342405
申请日：2008-12-23
申请人： Peter Turecek , Juergen Siekmann , Alfred Weber , Herbert Gritsch , Katalin Varadi , Susanne Vejda
发明人： Peter Turecek , Juergen Siekmann , Alfred Weber , Herbert Gritsch , Katalin Varadi , Susanne Vejda
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
摘要： The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.
摘要翻译： 本发明涉及一种用于测定与蛋白质结合的生理学上可接受的聚合物分子的量的方法，能够特异性结合生理上可接受的聚合物分子的抗体或其它组合物，以及含有所述抗体或组合物的试剂盒。
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2.发明申请Method and Compositions for Specifically Detecting Physiologically Acceptable Polymer Molecules 有权用于特异性检测生理上可接受的聚合物分子的方法和组合物公开(公告)号：US20090220993A1
公开(公告)日：2009-09-03
申请号：US12342405
申请日：2008-12-23
申请人： Peter Turecek , Juergen Siekmann , Alfred Weber , Herbert Gritsch , Katalin Varadi , Susanne Vejda
发明人： Peter Turecek , Juergen Siekmann , Alfred Weber , Herbert Gritsch , Katalin Varadi , Susanne Vejda
IPC分类号： G01N33/566
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
摘要： The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.
摘要翻译： 本发明涉及一种用于测定与蛋白质结合的生理学上可接受的聚合物分子的量的方法，能够特异性结合生理上可接受的聚合物分子的抗体或其它组合物，以及含有所述抗体或组合物的试剂盒。
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3.发明授权Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) 有权使用可释放的PEG试剂（体外去PEG化）测定前药PEG蛋白缀合物中活性成分的方法公开(公告)号：US09274122B2
公开(公告)日：2016-03-01
申请号：US12582497
申请日：2009-10-20
申请人： Katalin Varadi , Gerald Schrenk , Hanspeter Rottensteiner , Peter Turecek , Alfred Weber , Heinz Anderle , Sean M. Culbertson , Zhihao Fang , Harold Zappe , Ping Zhang , Mary J. Bossard
发明人： Katalin Varadi , Gerald Schrenk , Hanspeter Rottensteiner , Peter Turecek , Alfred Weber , Heinz Anderle , Sean M. Culbertson , Zhihao Fang , Harold Zappe , Ping Zhang , Mary J. Bossard
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
摘要： The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
摘要翻译： 本发明涉及从用可逆连接的水溶性聚合物改性的蛋白质强制释放水溶性聚合物如聚乙二醇（PEG）和聚唾液酸（PSA）的体外测定系统的开发。 本发明包括用于分析水溶性聚合物的释放并测量重新获得的蛋白质活性的方法。 本发明还包括适用于用可释放水溶性聚合物（包括聚合物如PEG和PSA）改性的蛋白质的质量控制的方法。
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4.发明申请METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION) 有权使用可释放的PEG试剂（在体外去PEG化）中测定丙型肝素PEG蛋白质结合物中活性成分的方法公开(公告)号：US20100112607A1
公开(公告)日：2010-05-06
申请号：US12582497
申请日：2009-10-20
申请人： Katalin Varadi , Gerald Schrenk , Hanspeter Rottensteiner , Peter Turecek , Alfred Weber , Heinz Anderle , Sean M. Culbertson , Zhihao Fang , Harold Zappe , Ping Zhang , Mary J. Bossard
发明人： Katalin Varadi , Gerald Schrenk , Hanspeter Rottensteiner , Peter Turecek , Alfred Weber , Heinz Anderle , Sean M. Culbertson , Zhihao Fang , Harold Zappe , Ping Zhang , Mary J. Bossard
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
摘要： The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
摘要翻译： 本发明涉及从用可逆连接的水溶性聚合物改性的蛋白质强制释放水溶性聚合物如聚乙二醇（PEG）和聚唾液酸（PSA）的体外测定系统的开发。 本发明包括用于分析水溶性聚合物的释放并测量重新获得的蛋白质活性的方法。 本发明还包括适用于用可释放水溶性聚合物（包括聚合物如PEG和PSA）改性的蛋白质的质量控制的方法。
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5.发明申请DETECTION OF PHYSIOLOGICALLY ACCEPTABLE POLYMER MOLECULES USING NEAR INFRARED SPECTROSCOPY 审中-公开使用近红外光谱检测生理学上可接受的聚合物分子公开(公告)号：US20100152115A1
公开(公告)日：2010-06-17
申请号：US12636382
申请日：2009-12-11
CPC分类号： G01N33/6842 , G01N21/359 , G01N33/86 , G01N2333/745 , G01N2333/755 , G01N2333/76 , Y10T436/203332
摘要： The present invention relates, in general, to methods for detecting the amount of a polymer on a protein using near-infrared spectroscopy. Measurement of the number of polymer moieties per protein molecule allows for production of molecules having a uniform number of polymer moieties, which is useful in the production of pharmaceutical compositions.
摘要翻译： 本发明一般涉及使用近红外光谱法检测蛋白质上的聚合物的量的方法。 每个蛋白质分子的聚合物部分的数量的测量允许生产具有均匀数目的聚合物部分的分子，其可用于制备药物组合物。
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6.发明申请THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME 审中-公开具有增加的半衰期的治疗性蛋白质及其制备方法公开(公告)号：US20120329127A1
公开(公告)日：2012-12-27
申请号：US13481260
申请日：2012-05-25
IPC分类号： C07K1/04 , C07K17/10 , C07K17/08 , C08G79/02 , C08G65/333 , C08G73/06 , C08F16/06 , C12N9/96 , C08G63/91
摘要： The present disclosure relates to materials and methods of conjugating a water soluble polymer to a therapeutic protein.
摘要翻译： 本公开涉及将水溶性聚合物与治疗性蛋白质缀合的材料和方法。
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7.发明申请METHODS FOR DIFFERENTIATING PLASMA- DERIVED PROTEIN FROM RECOMBINANT PROTEIN IN A SAMPLE 有权从样品中重组蛋白质分离衍生的蛋白质的方法公开(公告)号：US20120040379A1
公开(公告)日：2012-02-16
申请号：US13281519
申请日：2011-10-26
申请人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
发明人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
IPC分类号： G01N33/577 , G01N33/82 , G01N33/573 , G01N33/53
CPC分类号： G01N33/6842 , G01N2333/4724 , G01N2333/755 , Y10S436/827 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
摘要： The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.
摘要翻译： 本发明一般涉及当血浆蛋白质和重组蛋白质基本上相同的蛋白质时，基于蛋白质糖基化的差异，在样品中检测和定量血浆衍生的蛋白质和重组蛋白质的方法。
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8.发明授权Methods for differentiating plasma-derived protein from recombinant protein in a sample 有权在样品中从重组蛋白质中分离血浆来源的蛋白质的方法公开(公告)号：US08828676B2
公开(公告)日：2014-09-09
申请号：US13281519
申请日：2011-10-26
申请人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
发明人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
CPC分类号： G01N33/6842 , G01N2333/4724 , G01N2333/755 , Y10S436/827 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
摘要： The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.
摘要翻译： 本发明一般涉及当血浆蛋白质和重组蛋白质基本上相同的蛋白质时，基于蛋白质糖基化的差异，在样品中检测和定量血浆衍生的蛋白质和重组蛋白质的方法。
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9.发明授权Methods for differentiating plasma-derived protein from recombinant protein in a sample 有权在样品中从重组蛋白质中分离血浆来源的蛋白质的方法公开(公告)号：US08114633B2
公开(公告)日：2012-02-14
申请号：US12341098
申请日：2008-12-22
申请人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
发明人： Alfred Weber , Peter Turecek , Hans-Peter Schwarz
CPC分类号： G01N33/6842 , G01N2333/4724 , G01N2333/755 , Y10S436/827 , Y10T436/10 , Y10T436/105831 , Y10T436/106664
摘要： The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.
摘要翻译： 本发明一般涉及当血浆蛋白质和重组蛋白质基本上相同的蛋白质时，基于蛋白质糖基化的差异，在样品中检测和定量血浆衍生的蛋白质和重组蛋白质的方法。
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10.发明授权Ethanol dependence of alpha1 antitrypsin C-terminal lys truncation by basic carboxypeptidases 有权乙酸依赖的α1抗胰蛋白酶C-末端裂解基本羧肽酶公开(公告)号：US08772240B2
公开(公告)日：2014-07-08
申请号：US11749944
申请日：2007-05-17
CPC分类号： C07K1/30 , A61K38/57 , C07K14/473 , C07K14/8125
摘要： Methods of preparing alpha-1-antiproteinase inhibitor and controlling the amount of des-lys alpha-1-antiproteinase inhibitor in the preparation, and compositions comprising the same, as well as methods of treatment using the same are provided.
摘要翻译： 提供了制备α-1-抗蛋白酶抑制剂并控制制剂中des-lysα-1-抗蛋白酶抑制剂的量的方法，以及包含其的组合物以及使用其的治疗方法。
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