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28 条记录 (耗时 0.038 秒)

    Control of function of intracellular Ca ion
    11.
    发明授权
    Control of function of intracellular Ca ion 失效
    细胞内Ca离子的功能控制

    公开(公告)号：US07276582B2

    公开(公告)日：2007-10-02

    申请号：US11283193

    申请日：2005-11-18

    申请人： Katsuhiko Mikoshiba ,  Junji Hirota ,  Hideaki Ando

    发明人： Katsuhiko Mikoshiba ,  Junji Hirota ,  Hideaki Ando

    IPC分类号： A61K38/44 ,  A61K38/00

    CPC分类号： A61K38/1709 ,  C07K14/4702

    摘要： Analysis of substance capable of binding with inositol-1, 4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4, 5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calsium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.

    摘要翻译： 分析能够与肌醇-1,4,5-三磷酸（IP 3 N 3）受体（IP 3 R R）结合的物质，优选具有IP 3 < 分析IP 3的功能; 以及建立与IP 3 R相关的各种故障和疾病的治疗或诊断方法。 特别地，控制细胞内Ca 2+释放的活性。 更具体地，由碳酸酐酶相关蛋白质（肌醇-1,5,5-三磷酸（IP 3 N 3 R））的肌醇-1,4,5-三磷酸（IP 3 N 3 R）活性调节剂 鲤鱼）; 由碳酸酐酶相关蛋白（CARP）组成的用于细胞内钙离子释放的控制剂; 及其控制方法。

    Numb protein expression inhibitors by Musashi
    12.
    发明授权
    Numb protein expression inhibitors by Musashi 有权
    Musashi的Numb蛋白表达抑制剂

    公开(公告)号：US07264793B2

    公开(公告)日：2007-09-04

    申请号：US10343311

    申请日：2001-11-22

    申请人： Takao Imai ,  Akinori Tokunaga ,  Tetsu Yoshida ,  Katsuhiko Mikoshiba ,  Masato Nakafuku ,  Hideyuki Okano

    发明人： Takao Imai ,  Akinori Tokunaga ,  Tetsu Yoshida ,  Katsuhiko Mikoshiba ,  Masato Nakafuku ,  Hideyuki Okano

    IPC分类号： A61K49/00 ,  A61K38/00 ,  C12P21/06 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide.By the present invention, a new function of Musashi protein has been elucidated. Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.

    摘要翻译： 一种Numb蛋白质表达抑制剂，其包含Musashi蛋白质作为活性成分的具有通过在Musashi蛋白质的氨基酸序列中替换，缺失，添加或插入至少一个氨基酸而获得的氨基酸序列的多肽，或编码所述 多肽。 通过本发明，已经阐明了Musashi蛋白质的新功能。 具体地说，Musashi蛋白抑制具有神经元分化调节功能的Numb蛋白的表达，并增强Notch信号系统的活性，使得Musashi蛋白可以用作中枢神经系统各种疾病的治疗剂。

    REAGENT FOR DETECTION OF AUTOANTIBODY AND KIT FOR DIAGNOSIS OF AUTOIMMUNE DISEASE
    16.
    发明申请
    REAGENT FOR DETECTION OF AUTOANTIBODY AND KIT FOR DIAGNOSIS OF AUTOIMMUNE DISEASE 审中-公开
    用于检测自身免疫性疾病的诊断试剂和试剂盒的试剂

    公开(公告)号：US20100035360A1

    公开(公告)日：2010-02-11

    申请号：US12306577

    申请日：2007-06-28

    申请人： Katsuhiko Mikoshiba

    发明人： Katsuhiko Mikoshiba

    IPC分类号： G01N33/566

    CPC分类号： C07K14/705 ,  G01N33/564 ,  G01N2800/101

    摘要： This invention is intended to discover a novel autoantibody that can be used as a marker for an autoimmune disease and to provide an effective means for diagnosing an autoimmune disease. Disclosed is a reagent for detecting an autoantibody comprising an inositol 1,4,5-trisphosphate receptor (IP3R) protein and/or a fragment thereof.

    摘要翻译： 本发明旨在发现可用作自身免疫性疾病的标志物并提供用于诊断自身免疫性疾病的有效手段的新型自身抗体。 公开了一种用于检测包含肌醇1,4,5-三磷酸受体（IP3R）蛋白和/或其片段的自身抗体的试剂。

    Intracellular calcium concentration increase inhibitors
    17.
    发明授权
    Intracellular calcium concentration increase inhibitors 失效
    细胞内钙浓度增加抑制剂

    公开(公告)号：US07217701B2

    公开(公告)日：2007-05-15

    申请号：US10492150

    申请日：2002-10-10

    申请人： Katsuhiko Mikoshiba ,  Hirohide Iwasaki ,  Takayuki Maruyama ,  Shin-ichi Hamano

    发明人： Katsuhiko Mikoshiba ,  Hirohide Iwasaki ,  Takayuki Maruyama ,  Shin-ichi Hamano

    IPC分类号： A61K31/69 ,  C07F5/02

    CPC分类号： A61K31/69

    摘要： An intracellular calcium concentration increase inhibitor containing as the active ingredient (1) a boron compound represented by the formula (I). The compound represented by the formula (I) inhibits the increase of the intracellular calcium concentration, and therefore it is deemed to be useful as an agent for the prophylaxis and/or treatment of platelet aggregation, ischemic diseases in hearts and brains, immune deficiency diseases, allorgosis, bronchial asthma, hypertension, cerebrovascular spasm, various renal diseases, pancreatitis, Alzheimer's disease, etc.

    摘要翻译： 含有作为活性成分的细胞内钙浓度增加抑制剂（1）由式（I）表示的硼化合物。 由式（I）表示的化合物抑制细胞内钙浓度的增加，因此被认为可用作预防和/或治疗血小板聚集，心脏和脑中缺血性疾病，免疫缺陷病 ，多动症，支气管哮喘，高血压，脑血管痉挛，各种肾脏疾病，胰腺炎，阿尔茨海默病等。

    Neurogenesis inducing gene
    19.
    发明授权
    Neurogenesis inducing gene 失效
    神经发生诱导基因

    公开(公告)号：US06277594B1

    公开(公告)日：2001-08-21

    申请号：US09172045

    申请日：1998-09-28

    申请人： Katsuhiko Mikoshiba ,  Jun Aruga ,  Takeharu Nagai ,  Katsunori Nakata

    发明人： Katsuhiko Mikoshiba ,  Jun Aruga ,  Takeharu Nagai ,  Katsunori Nakata

    IPC分类号： C12P2106

    CPC分类号： C07K14/463

    摘要： A neurogenesis inducing gene coding for the following protein (a) or (b): (a) a protein consisting of the amino acid sequence shown in SEQ ID NO: 2 (b) a protein which consists of the amino acid sequence shown in SEQ ID NO: 2 having deletion, substitution or addition of at least one amino acid and which has neurogenesis inducing activity.

    摘要翻译： 编码以下蛋白质的神经发生诱导基因（a）或（b）:( a）由SEQ ID NO：2（b）所示的氨基酸序列组成的蛋白质，由SEQ ID NO：2（b）所示的氨基酸序列组成的蛋白质 ID NO：2具有至少一个氨基酸的缺失，取代或添加并具有神经发生诱导活性。

    Control of function of intracellular Ca ion
    20.
    发明授权
    Control of function of intracellular Ca ion 有权
    细胞内Ca离子的功能控制

    公开(公告)号：US07709441B2

    公开(公告)日：2010-05-04

    申请号：US11811588

    申请日：2007-06-11

    申请人： Katsuhiko Mikoshiba ,  Junji Hirota ,  Hideaki Ando

    发明人： Katsuhiko Mikoshiba ,  Junji Hirota ,  Hideaki Ando

    IPC分类号： A61K8/66 ,  A61K38/00

    CPC分类号： A61K38/1709 ,  C07K14/4702

    摘要： Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.

    摘要翻译： 分析能够与肌醇-1,4,5-三磷酸（IP3）受体（IP3R）结合的物质，优选具有IP3R的调节结构域; 分析IP3R的功能; 并建立与IP3R相关的各种故障和疾病的治疗或诊断方法。 特别是控制细胞内Ca2 +释放的活性。 更具体地，由碳酸酐酶相关蛋白（CARP）组成的肌醇-1,4,5-三磷酸（IP3）受体（IP3R）的活性调节剂; 由碳酸酐酶相关蛋白（CARP）组成的细胞内钙释放控制剂; 及其控制方法。