公开(公告)号：US20140051720A1

公开(公告)日：2014-02-20

申请号：US14110437

申请日：2012-04-05

申请人： Keith Biggadike ,  Gianpaolo Bravi ,  Aurelie Cecile Champigny ,  Diane Mary Coe ,  Deborah Needham ,  Dainiel Terence Tape

发明人： Keith Biggadike ,  Gianpaolo Bravi ,  Aurelie Cecile Champigny ,  Diane Mary Coe ,  Deborah Needham ,  Dainiel Terence Tape

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： A compound of formula (I) wherein X represents a H atom, or a CH2OH group, Y represents a H atom, or a CH2OH group, but X and Y are not both CH2OH groups and Ar is selected from or a pharmaceutically acceptable salt thereof.

摘要翻译： 式（I）的化合物，其中X表示H原子，或CH 2 OH基，Y表示H原子或CH 2 OH基，但X和Y不同时为CH 2 OH基，Ar选自其药学上可接受的盐 。

公开(公告)号：US09346806B2

公开(公告)日：2016-05-24

申请号：US13272956

申请日：2011-10-13

申请人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  A61P11/06 ,  C07D473/18 ,  C07D473/16

CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D473/16 ,  C07D473/18

摘要： Compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 式（I）化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US20120035193A1

公开(公告)日：2012-02-09

申请号：US13272956

申请日：2011-10-13

申请人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  A61P11/06

CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D473/16 ,  C07D473/18

摘要： Compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 式（I）化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US20110135671A1

公开(公告)日：2011-06-09

申请号：US13058489

申请日：2009-08-07

申请人： Helene Bazin-Lee ,  Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Naimisha Trivedi

发明人： Helene Bazin-Lee ,  Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Naimisha Trivedi

IPC分类号： A61K39/00 ,  C07D473/18 ,  C07D473/16 ,  A61K31/522 ,  A61P35/00 ,  A61P31/00 ,  A61P29/00 ,  A61P37/08 ,  A61P37/04

CPC分类号： C07D473/16 ,  C07D473/18

摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 2 to 6; R2 is hydrogen, C1-6alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为2〜6的整数; R 2是氢，C 1-6烷基或C 3-7环烷基C 1-6烷基; 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US20100075995A1

公开(公告)日：2010-03-25

申请号：US12537392

申请日：2009-08-07

申请人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  C07D473/18 ,  A61P11/06

CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D473/16 ,  C07D473/18

摘要： Compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 式（I）化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US08754101B2

公开(公告)日：2014-06-17

申请号：US14110437

申请日：2012-04-05

申请人： Keith Biggadike ,  Gianpaolo Bravi ,  Aurelie Cecile Champigny ,  Diane Mary Coe ,  Deborah Needham ,  Daniel Terence Tape

发明人： Keith Biggadike ,  Gianpaolo Bravi ,  Aurelie Cecile Champigny ,  Diane Mary Coe ,  Deborah Needham ,  Daniel Terence Tape

IPC分类号： C07D491/02 ,  C07D498/02 ,  A01N43/42 ,  A61K31/44

CPC分类号： C07D471/04

摘要： A compound of formula (I) wherein X represents a H atom, or a CH2OH group, Y represents a H atom, or a CH2OH group, but X and Y are not both CH2OH groups and Ar is selected from or a pharmaceutically acceptable salt thereof.

摘要翻译： 式（I）的化合物，其中X表示H原子，或CH 2 OH基，Y表示H原子或CH 2 OH基，但X和Y不同时为CH 2 OH基，Ar选自其药学上可接受的盐 。

公开(公告)号：US08067426B2

公开(公告)日：2011-11-29

申请号：US12537392

申请日：2009-08-07

申请人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： C07D473/18 ,  A61K31/522 ,  C07D473/40 ,  C07D473/16 ,  A61P37/08 ,  A61P11/06

CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D473/16 ,  C07D473/18

摘要： Compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 式（I）化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US20110229500A1

公开(公告)日：2011-09-22

申请号：US13058470

申请日：2009-08-07

申请人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Keith Biggadike ,  Diane Mary Coe ,  Xiao Qing Lewell ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  C07D473/34 ,  A61K31/55 ,  A61K39/00 ,  A61P37/00 ,  A61P11/06 ,  A61P37/08 ,  A61P29/00

CPC分类号： A61K31/522 ,  A61K9/0043 ,  A61K31/55 ,  A61K45/06 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D473/16 ,  C07D473/18

摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。

公开(公告)号：US20070004807A1

公开(公告)日：2007-01-04

申请号：US11207967

申请日：2005-08-19

申请人： Keith Biggadike ,  Diane Coe ,  Dean Edney ,  Stephen Guntrip ,  Abigai Halton ,  Brian Looker ,  Michael Monteith ,  Rebecca Moore ,  Rajnikant Patel ,  Panayiotis Procopiou

发明人： Keith Biggadike ,  Diane Coe ,  Dean Edney ,  Stephen Guntrip ,  Abigai Halton ,  Brian Looker ,  Michael Monteith ,  Rebecca Moore ,  Rajnikant Patel ,  Panayiotis Procopiou

IPC分类号： A61K31/18 ,  C07C311/35

CPC分类号： C07D295/26 ,  C07C311/27 ,  C07C311/29 ,  C07C311/58 ,  C07C2601/04 ,  C07C2601/14 ,  C07D295/13

摘要： The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.

摘要翻译： 本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。

公开(公告)号：US20120142651A1

公开(公告)日：2012-06-07

申请号：US13370493

申请日：2012-02-10

申请人： Keith Biggadike ,  Ian Buxton ,  Steven John Coote ,  Rosalyn Kay Nice ,  Kenton Lewis Reed ,  Amyn Sayani ,  Avinash Chander Sharma

发明人： Keith Biggadike ,  Ian Buxton ,  Steven John Coote ,  Rosalyn Kay Nice ,  Kenton Lewis Reed ,  Amyn Sayani ,  Avinash Chander Sharma

IPC分类号： A61K31/58 ,  A61P11/02

CPC分类号： A61K9/0078 ,  A61K9/0043 ,  A61K31/56 ,  A61K31/58 ,  A61K47/38

摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.

摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。