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公开(公告)号:US20120058984A1
公开(公告)日:2012-03-08
申请号:US13257098
申请日:2010-03-15
申请人: Catherine Mary Alder , Ian Robert Baldwin , Nicholas Paul Barton , Amanda Jennifer Campbell , Aurelie Cecile Champigny , John David Harling , Aoife Caitriona Maxwell , Juliet Kay Simpson , Ian Edward David Smith , Christopher John Tame , Caroline Wilson , James Michael Woolven
发明人: Catherine Mary Alder , Ian Robert Baldwin , Nicholas Paul Barton , Amanda Jennifer Campbell , Aurelie Cecile Champigny , John David Harling , Aoife Caitriona Maxwell , Juliet Kay Simpson , Ian Edward David Smith , Christopher John Tame , Caroline Wilson , James Michael Woolven
IPC分类号: A61K31/506 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P11/00 , A61P37/08 , A61P37/00 , A61P37/06 , A61P29/00 , A61P31/18 , A61P7/06 , A61P25/00 , A61P11/06 , A61P11/08 , A61P17/00 , A61P17/06 , A61P3/10 , A61P5/16 , A61P27/02 , A61P1/00 , C07D417/12
CPC分类号: C07D513/04 , C07D417/12 , C07D417/14
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Itk activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是Itk活性。
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2.
公开(公告)号:US08754101B2
公开(公告)日:2014-06-17
申请号:US14110437
申请日:2012-04-05
申请人: Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Daniel Terence Tape
发明人: Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Daniel Terence Tape
IPC分类号: C07D491/02 , C07D498/02 , A01N43/42 , A61K31/44
CPC分类号: C07D471/04
摘要: A compound of formula (I) wherein X represents a H atom, or a CH2OH group, Y represents a H atom, or a CH2OH group, but X and Y are not both CH2OH groups and Ar is selected from or a pharmaceutically acceptable salt thereof.
摘要翻译: 式(I)的化合物,其中X表示H原子,或CH 2 OH基,Y表示H原子或CH 2 OH基,但X和Y不同时为CH 2 OH基,Ar选自其药学上可接受的盐 。
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3.N-Cyclobutyl - Imidazopyridine - Methylamine As TRPV1 Antagonists 失效
标题翻译: N-环丁基 - 咪唑并吡啶 - 甲胺作为TRPV1拮抗剂公开(公告)号:US20140051720A1
公开(公告)日:2014-02-20
申请号:US14110437
申请日:2012-04-05
申请人: Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Dainiel Terence Tape
发明人: Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Dainiel Terence Tape
IPC分类号: C07D471/04
CPC分类号: C07D471/04
摘要: A compound of formula (I) wherein X represents a H atom, or a CH2OH group, Y represents a H atom, or a CH2OH group, but X and Y are not both CH2OH groups and Ar is selected from or a pharmaceutically acceptable salt thereof.
摘要翻译: 式(I)的化合物,其中X表示H原子,或CH 2 OH基,Y表示H原子或CH 2 OH基,但X和Y不同时为CH 2 OH基,Ar选自其药学上可接受的盐 。
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