NOVEL DNA SEQUENCES, VECTORS AND PROTEINS OF AVIAN INFLUENZA HEMAGGLUTININ
    17.
    发明申请
    NOVEL DNA SEQUENCES, VECTORS AND PROTEINS OF AVIAN INFLUENZA HEMAGGLUTININ 失效
    AVIAN INFLUENZA HEMAGGLUTININ的新型DNA序列,载体和蛋白

    公开(公告)号:US20090106864A1

    公开(公告)日:2009-04-23

    申请号:US12299404

    申请日:2007-06-08

    摘要: The subject invention provides novel amino acid sequences (including a consensus sequence) of the Avian Influenza A virus hemagglutinin protein. These newly constructed genes are designed to provide a broader spectrum of activity across the serotype family thus providing a basis for a vaccine that has broad heterologous disease protection. The novel genes have been further improved by the addition of strategic glycosylation sites into the amino acids sequences that they encode. These genes can also, optionally, be codon optimized for plant expression, inserted into the appropriate vector and cloned into plants for expression. Polypeptides produced by recombinant host cells or transgenic plants can also be used as source of antigen for the formulation of vaccines for the control of influenza in susceptible individuals. Additionally, transgenic plant material may also be used as source of antigen for the formulation of vaccines for the control of influenza in susceptible individuals.

    摘要翻译: 本发明提供禽流感A病毒血凝素蛋白的新型氨基酸序列(包括共有序列)。 这些新构建的基因被设计为提供跨血清型家族的更广泛的活性范围,从而为具有广泛异源疾病保护的疫苗提供基础。 通过在其编码的氨基酸序列中加入战略糖基化位点,进一步改善了这些新基因。 这些基因也可任选地优化用于植物表达的密码子,插入合适的载体中并克隆到植物中用于表达。 通过重组宿主细胞或转基因植物产生的多肽也可以用作疫苗来源,用于制定用于控制易感个体中的流感的疫苗。 另外,转基因植物材料也可以用作疫苗的来源,用于制定用于控制易感个体中的流感的疫苗。