摘要:
A set of N×M signals are acquired from an object, where N is the number of array elements and M corresponds to variations in data acquisition and/or processing parameters. The parameters include transmit aperture functions, transmit waveforms, receive aperture functions, and receive filtering functions in space and/or time. A coherence factor is computed as a ratio of the energy of the coherent sum to the energy of the at-least-partially incoherent sum of channel or image signals acquired with at least one different parameter. Partial beamformed data may be used for channel coherence calculation. For image domain coherence, a component image is formed for each different transmit beam or receive aperture function, and a coherence factor image is computed using the set of component images. The coherence factor image is displayed or used to modify or blend other images formed of the same region.
摘要:
In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of treating non-small cell lung cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor.
摘要:
In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the invention provides a method of treating cancer comprising administering to a subject a combination of topoisomerase inhibitor and PARP inhibitor. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase and a topoisomerase, as well as providing formulations and modes of administering such compositions.
摘要:
Synthetic transmit aperture is provided for three-dimensional ultrasound imaging. A transducer may have separate transmit and receive elements. Broad beams are transmitted, allowing fewer transmit elements and/or more rapid scanning. A multidimensional receive array generates data in response to sequential transmissions, such as transmissions from different angles. The data is combined to increase resolution. A transducer array with offset transmit elements for forming a transmit line source may be used.
摘要:
An improvement to the method for harmonic imaging including the steps of (a) transmitting ultrasonic energy at a fundamental frequency and (b) receiving reflected ultrasonic energy at a harmonic of the fundamental frequency is provided. The transmitting step includes the step of: applying the plurality of waveforms to a respective plurality of transducer elements, a first waveform of the plurality of waveforms characterized by a first value of a harmonic power ratio, waveforms transmitted from the transducer elements and corresponding to the plurality of waveforms summing as an acoustic waveform substantially at the point, the acoustic waveform characterized by a second value of the harmonic power ratio less than the first value. The imaging method can also include a step for subdividing the transmit aperture into two or more subapertures, each subaperture having at least four adjacent transducer elements. The subapertures are phased differently with respect to one another to selectively reduce either fundamental components or harmonic components of echoes from tissue. These techniques can be used to improve contrast agent harmonic imaging as well as tissue harmonic imaging, depending upon the phase shift selected.
摘要:
In one aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating uterine cancer, endometrial cancer, or ovarian cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要:
In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要:
In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要:
A method is provided to improve the frame-rate in color-flow ultrasound imaging using simultaneous spatially-distinct transmit beams with one or more frequency bands per transmit beam. Pulses of different center frequencies are used simultaneously in different (lateral and/or elevational) directions, thereby reducing the scanning time and improving the frame-rates. Optionally, a multi-modal pulse is used, and flow is estimated separately for the different frequencies. The flow estimates for these pulses are appropriately combined to improve low-velocity sensitivity and to reduce aliasing. A flow sample count with two or more different pulse repetition intervals can be used to further improve low-flow sensitivity and minimize aliasing.
摘要:
A medical diagnostic ultrasound transducer system has at least a first and a second set of transducer layers of an element. Each set has one or more transducer layers with independent electrical access. A transmit event through a first set of transducer layers with broadband electrical signals generates acoustic signals containing at least two different frequency bands, and a receive event through a second and different set of transducer layers receives multiple tissue harmonic signals to generate a wide bandwidth response. Fundamental signals can be reduced with a pulse inversion technique through a second transmit event of inverted pulses, a second receive event and superposition of signals from the two receive events.