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公开(公告)号：US20120157429A1
公开(公告)日：2012-06-21
申请号：US13280670
申请日：2011-10-25
申请人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
发明人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
IPC分类号： A61K31/506 , C07D403/04 , C07D413/14 , A61K31/5377 , C07D403/10 , C12N9/99 , A61P9/00 , A61P25/28 , A61P37/00 , A61P37/06 , A61P29/00 , C07D401/04 , A61P35/00
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20100160287A1
公开(公告)日：2010-06-24
申请号：US12564156
申请日：2009-09-22
申请人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
发明人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
IPC分类号： A61K31/506 , C07D401/04 , C07D403/04 , C07D417/10 , C07D403/10 , C07D405/10 , A61P35/00 , A61P9/00 , A61P19/08 , A61P37/06 , A61P29/00 , A61P37/00 , A61P31/12 , C12N5/00
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120165307A1
公开(公告)日：2012-06-28
申请号：US13409702
申请日：2012-03-01
申请人： Luc Farmer , Gabriel Matinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Matinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/53 , A61K31/517 , A61P35/00 , A61P9/00 , A61P25/28 , A61P37/06 , A61P29/00 , A61P37/00 , A61P25/00 , A61P3/10 , A61P37/04 , A61P37/08 , A61P11/06 , A61P25/16 , A61P25/18 , A61P9/10 , A61P17/14 , A61P35/02 , C12N9/99
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08501446B2
公开(公告)日：2013-08-06
申请号：US13441287
申请日：2012-04-06
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： C12N9/99 , C07D471/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20090176763A1
公开(公告)日：2009-07-09
申请号：US12273799
申请日：2008-11-19
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： A61K31/55 , C07D401/14 , A61K31/506 , C07D243/08 , A61K31/551 , C07D403/14 , A61K31/496 , C07D471/02 , A61K31/437 , C07D413/14 , A61K31/5377 , A61P37/00 , A61P29/00 , A61P25/00 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20060183761A1
公开(公告)日：2006-08-17
申请号：US11346048
申请日：2006-02-01
申请人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
发明人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120258958A1
公开(公告)日：2012-10-11
申请号：US13441287
申请日：2012-04-06
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： A61K31/551 , A61K31/55 , A61P37/08 , A61P11/06 , C12N9/99 , A61P29/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61K31/506 , A61P37/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08188281B2
公开(公告)日：2012-05-29
申请号：US12273799
申请日：2008-11-19
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07507826B2
公开(公告)日：2009-03-24
申请号：US11093821
申请日：2005-03-30
申请人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号： C07D471/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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![Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein kinases](/abs-image/US/2014/01/21/US08633205B2/abs.jpg.150x150.jpg)
20.发明授权公开(公告)号：US08633205B2
公开(公告)日：2014-01-21
申请号：US11346048
申请日：2006-02-02
申请人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
发明人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
IPC分类号： C07D487/04 , A61K31/519 , A61K31/497 , A61P35/00 , A61P37/06 , A61P25/28
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of the following formula: which are useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及下式的化合物：其可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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