公开(公告)号：US20050090460A1

公开(公告)日：2005-04-28

申请号：US10946339

申请日：2004-09-21

申请人： Guoqiang Wang ,  Yulin Peng ,  Yanchun Wang ,  Ly Phan ,  Yat Or

发明人： Guoqiang Wang ,  Yulin Peng ,  Yanchun Wang ,  Ly Phan ,  Yat Or

IPC分类号： A61K31/7052 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20050282758A1

公开(公告)日：2005-12-22

申请号：US11154260

申请日：2005-06-16

申请人： Deqiang Niu ,  Guoqiang Wang ,  Yat Or ,  Ly Phan

发明人： Deqiang Niu ,  Guoqiang Wang ,  Yat Or ,  Ly Phan

IPC分类号： A61K31/7052 ,  A61K45/06 ,  C07H17/08

CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20060058248A1

公开(公告)日：2006-03-16

申请号：US11257680

申请日：2005-10-25

申请人： Guoyou Xu ,  Datong Tang ,  Yonghua Gai ,  Heejin Kim ,  Guoqiang Wang ,  Ly Phan ,  Yat Or ,  Zhe Wang

发明人： Guoyou Xu ,  Datong Tang ,  Yonghua Gai ,  Heejin Kim ,  Guoqiang Wang ,  Ly Phan ,  Yat Or ,  Zhe Wang

IPC分类号： C07H17/08 ,  A61K31/7052 ,  C07D403/04

CPC分类号： C07D401/04

摘要： The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (IX-c):

摘要翻译： 本发明涉及制备6-11双环红霉素衍生物的方法和中间体。 特别地，本发明涉及制备式（Ⅸ-c）化合物的方法和中间体：

公开(公告)号：US20050143326A1

公开(公告)日：2005-06-30

申请号：US10745856

申请日：2003-12-24

申请人： Ly Phan ,  Yat Or ,  Jay Farmer

发明人： Ly Phan ,  Yat Or ,  Jay Farmer

IPC分类号： A61K31/365 ,  A61K31/70 ,  A61K31/7048 ,  C07D313/00 ,  C07D313/06 ,  C07D313/20 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formulae I, II, III or IV or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

公开(公告)号：US20070082853A1

公开(公告)日：2007-04-12

申请号：US11545241

申请日：2006-10-10

申请人： Yat Or ,  Guoqiang Wang ,  Tongzhu Liu ,  Ly Phan

发明人： Yat Or ,  Guoqiang Wang ,  Tongzhu Liu ,  Ly Phan

IPC分类号： C07H17/08 ,  A61K31/7052

CPC分类号： C07H17/08

摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

公开(公告)号：US20050009763A1

公开(公告)日：2005-01-13

申请号：US10841249

申请日：2004-05-07

申请人： Yat Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Phan

发明人： Yat Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Phan

IPC分类号： C07H17/08 ,  A61K31/7048

CPC分类号： C07H17/08

摘要： Novel 6, 11-4-carbon bridged erythromycin derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are methods for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.

摘要翻译： 描述了新颖的6,11-碳桥连红霉素衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。

公开(公告)号：US20050267054A1

公开(公告)日：2005-12-01

申请号：US11167493

申请日：2005-06-27

申请人： Richard Clark ,  Stevan Djuric ,  Zhenkun Ma ,  Ly Phan ,  Michael Rupp

发明人： Richard Clark ,  Stevan Djuric ,  Zhenkun Ma ,  Ly Phan ,  Michael Rupp

IPC分类号： A61K31/7048 ,  C07H17/08

CPC分类号： C07H17/08

摘要： Antibacterial compounds with improved pharmacokinetic profiles having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.

摘要翻译： 具有式（I）的具有改善的具有式（I）的药代动力学特征的抗菌化合物及其前体药物的盐，前药和盐，用于制备该方法中使用的化合物和中间体的方法，含有该化合物的组合物，以及使用该方法预防和治疗细菌感染的方法 公开了化合物。

公开(公告)号：US20060166906A1

公开(公告)日：2006-07-27

申请号：US09978990

申请日：2001-10-16

申请人： Zhenkun Ma ,  Ly Phan ,  Richard Clark ,  Suoming Zhang ,  Stevan Djuric

发明人： Zhenkun Ma ,  Ly Phan ,  Richard Clark ,  Suoming Zhang ,  Stevan Djuric

IPC分类号： A61K31/7052 ,  C07H17/08

CPC分类号： C07H17/08

摘要： Compounds having formula (I) are useful for treating bacterial infections while avoiding the concomitant liability of gastrointestinal intolerance. Compositions containing the compounds and methods of treatment using the compounds are also disclosed.

摘要翻译： 具有式（I）的化合物可用于治疗细菌感染，同时避免胃肠道不耐受的伴随的责任。 还公开了含有化合物的组合物和使用该化合物的处理方法。