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11.发明授权Sulfonamide derivatives and methods of use thereof for improving the pharmacokinetics of a drug 有权磺酰胺衍生物及其用于改善药物的药代动力学的方法公开(公告)号：US09556202B2
公开(公告)日：2017-01-31
申请号：US14410846
申请日：2013-06-25
发明人： Craig A. Coburn , Milana Maletic , Richard Soll , Chunsing Li , Yunfu Luo , Zhiqi Qi
IPC分类号： C07D498/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04 , C07D401/14 , A61K31/496 , A61K31/4545 , A61K31/4985 , A61K31/4402 , A61K31/513 , A61K31/5377 , A61K31/5383 , C07D471/10 , C07D471/04 , A61K38/05 , C07D403/14 , C07D491/04 , A61K45/06
CPC分类号： C07D498/04 , A61K31/4402 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/5377 , A61K31/5383 , A61K38/05 , A61K45/06 , C07D401/14 , C07D403/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/04
摘要： The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.
摘要翻译： 本发明涉及式（I）的磺酰胺衍生物及其药学上可接受的盐，其中A，W，X，R 1，R 2，R 3，R 4和R 5如本文所定义。 本发明还涉及包含至少一种磺酰胺衍生物的组合物，以及使用磺酰胺衍生物来改善药物的药代动力学的方法。
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12.发明授权公开(公告)号：US09981969B2
公开(公告)日：2018-05-29
申请号：US14895406
申请日：2014-06-02
发明人： Craig A. Coburn , Milana Maletic , Yunfu Luo , Zhiqi Qi , Chunsing Li , Tingting Yu , Richard Soll
IPC分类号： C07D487/04 , C07D401/14 , C07D413/14 , A61K31/4985 , A61K31/5365 , C07D401/06 , C07D471/04 , C07D498/04 , A61K45/06 , A61K31/4375 , A61K31/4545 , A61K31/513 , A61K31/55 , C07D405/14 , A61K31/454 , A61K31/496 , A61K31/5383 , A61K31/551
CPC分类号： C07D487/04 , A61K31/4375 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/5365 , A61K31/5383 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/04 , C07D498/04 , A61K2300/00
摘要： The present invention relates to Imidazole Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, B, Y, R1 and R2 are as defined herein. The present invention also relates to compositions comprising at least one Imidazole Derivative, and methods of using the Imidazole Derivatives for inhibiting CYP450 3A. Inhibition of CYP450 3A can be used to improve the pharmacokinetics of a drug that is metabolized by CYP450 3A4.
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公开(公告)号：US20150246917A1
公开(公告)日：2015-09-03
申请号：US14711345
申请日：2015-05-13
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4985 , C07D401/14 , A61K31/4439 , C07D403/14 , A61K31/4184 , C07D403/12 , C07D413/14 , A61K31/423 , C07D405/14 , A61K31/4025 , C07D405/12 , A61K31/404 , A61K31/506 , A61K31/5377 , C07D498/04 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K31/437
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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公开(公告)号：US20170008906A1
公开(公告)日：2017-01-12
申请号：US15272669
申请日：2016-09-22
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D498/04 , A61K31/4178 , A61K31/553 , A61K45/06 , A61K31/5365
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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15.发明授权Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases 有权取代的苯并呋喃化合物及其用于治疗病毒性疾病的方法公开(公告)号：US09364482B2
公开(公告)日：2016-06-14
申请号：US14898768
申请日：2014-06-19
发明人： Xing Dai , Hong Liu , Anandan Palani , Shuwen He , Ravi Nargund , Dong Xiao , Nicolas Zorn , Qun Dang , Casey C. McComas , Xuanjia Peng , Peng Li , Richard Soll
IPC分类号： A61K31/65 , A61K31/519 , A61K31/517 , A61K31/437 , A61K31/4725 , A61K31/06 , C07D498/04 , C07D471/04 , C07D405/04 , C07D475/02 , C07D405/14 , A61K31/5365 , A61K31/53 , A61K45/06
CPC分类号： A61K31/5365 , A61K31/437 , A61K31/4725 , A61K31/517 , A61K31/519 , A61K31/53 , A61K45/06 , C07D405/04 , C07D405/14 , C07D471/04 , C07D475/02 , C07D498/04
摘要： The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的用途的式I化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。 （一世）
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16.发明申请TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C 有权四环杂环化合物及其用于治疗乙型肝炎的方法公开(公告)号：US20150368265A1
公开(公告)日：2015-12-24
申请号：US14766491
申请日：2014-02-03
发明人： Shuwen He , Xing Dai , Anandan Palani , Ravi Nargund , Zhong Lai , Nicolas Zorn , Dong Xiao , Qun Dang , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
IPC分类号： C07D498/14 , A61K31/5365 , A61K31/5377 , A61K45/06
CPC分类号： C07D498/14 , A61K31/5365 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. I
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。 一世
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公开(公告)号：US20140371138A1
公开(公告)日：2014-12-18
申请号：US14473117
申请日：2014-08-29
发明人： Craig A. Coburn , John A. McCauley , Steven W. Ludmerer , Kun Liu , Joseph P. Vacca , Hao Wu , Bin Hu , Richard Soll , Fei Sun , Xinghai Wang , Man Yan , Chengren Zhang , Mingwei Zheng , Bin Zhong , Jian Zhu
IPC分类号： C07K5/08 , A61K38/05 , A61K38/06 , C07D471/04 , A61K31/437 , C07K5/06 , A61K45/06
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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公开(公告)号：US20220356182A1
公开(公告)日：2022-11-10
申请号：US17324799
申请日：2021-05-19
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D471/04 , C07D407/14 , A61K31/4985 , A61K31/4439 , A61K31/4184 , A61K31/423 , A61K31/4025 , A61K31/519 , A61K31/404 , A61K31/506 , A61K31/5377 , A61K31/427 , A61K31/4245 , A61K31/475 , A61K31/536 , A61K31/4178 , A61K31/517 , A61K31/5386 , A61K31/553 , C07D487/04 , C07D401/14 , C07D403/14 , C07D403/12 , C07D413/14 , C07D405/14 , C07D405/12 , C07D417/14 , C07D409/14 , A61K31/437
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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公开(公告)号：US20200262836A1
公开(公告)日：2020-08-20
申请号：US16829878
申请日：2020-03-25
发明人： CRAIG A. COBURN , STEVEN W. LUDMERER , KUN LIU , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D471/04 , A61K31/437 , C07D409/14 , C07D417/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D403/12 , C07D403/14 , C07D401/14 , C07D487/04 , A61K31/553 , A61K31/5386 , A61K31/517 , A61K31/4178 , A61K31/536 , A61K31/475 , A61K31/4245 , A61K31/427 , A61K31/5377 , A61K31/506 , A61K31/404 , A61K31/519 , A61K31/4025 , A61K31/423 , A61K31/4184 , A61K31/4439 , A61K31/4985 , C07D407/14
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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公开(公告)号：US09090661B2
公开(公告)日：2015-07-28
申请号：US14473117
申请日：2014-08-29
发明人： Craig A. Coburn , John A. McCauley , Steven W. Ludmerer , Kun Liu , Joseph P. Vacca , Hao Wu , Bin Hu , Richard Soll , Fei Sun , Xinghai Wang , Man Yan , Chengren Zhang , Mingwei Zheng , Bin Zhong , Jian Zhu
IPC分类号： A61K31/4178 , C07D405/14 , C07K5/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/10 , A61K31/437 , A61K38/05 , A61K38/06 , A61K45/06 , C07K5/06
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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