公开(公告)号：US20230008022A1

公开(公告)日：2023-01-12

申请号：US17295497

申请日：2019-11-25

Applicant: Dane CLAUSEN ,  Ping CHEN ,  Xavier FRADERA ,  Liangqin GUO ,  Yongxin HAN ,  Shuwen HE ,  Xianhai HUANG ,  Joseph KOZLOWSKI ,  Guoqing LI ,  Theodore A. MARTINOT ,  Alexander PASTERNAK ,  Andreas VERRAS ,  Li XIAO ,  Wensheng YU ,  Rui ZHANG ,  Merck Sharp & Dohme Corp.

Inventor： Dane Clausen ,  Ping Chen ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Xianhai Huang ,  Joseph Kozlowski ,  Guoqing Li ,  Theodore A. Martinot ,  Alexander Pasternak ,  Andreas Verras ,  Li Xiao ,  Feng Ye ,  Wensheng Yu ,  Rui Zhang

IPC: C07D231/56 ,  C07D491/052 ,  C07D231/54 ,  A61K31/496 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  A61K31/5377 ,  C07D498/10 ,  C07D491/107 ,  C07D498/08 ,  C07D471/10 ,  C07D403/12 ,  C07D405/12 ,  C07D498/04 ,  C07D487/04 ,  C07D487/10 ,  A61K31/541 ,  C07D413/14

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20210380572A1

公开(公告)日：2021-12-09

申请号：US17282821

申请日：2019-10-11

Applicant: Merck Sharp & Dohme Corp.

Inventor： Dane Clausen ,  Ping Chen ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Jongwon Lim ,  Theodore A. Martinot ,  Alexander Pasternak ,  Li Xiao ,  Wensheng Yu

IPC: C07D413/14 ,  C07D401/06 ,  C07D401/14 ,  C07D413/06

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11034661B2

公开(公告)日：2021-06-15

申请号：US16495883

申请日：2018-03-23

Applicant: Merck Sharp & Dohme Corp. ,  Liangqin Guo ,  Yongxin Han ,  Kun Liu ,  Shuwen He ,  Joseph Kozlowski ,  Ravi Nargund ,  Wensheng Yu ,  Hongjun Zhang ,  Qinglin Pu ,  Derun Li ,  Abdelghani Achab ,  Guoqing Li

Inventor： Liangqin Guo ,  Yongxin Han ,  Kun Liu ,  Shuwen He ,  Joseph Kozlowski ,  Ravi Nargund ,  Wensheng Yu ,  Hongjun Zhang ,  Qinglin Pu ,  Derun Li ,  Abdelghani Achab ,  Guoqing Li

IPC: C07D271/08 ,  C07D413/12

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10988487B2

公开(公告)日：2021-04-27

申请号：US16326408

申请日：2017-08-24

Applicant: Merck Sharp & Dohme Corp.

Inventor： Kun Liu ,  Abdelghani Achab ,  Purakkattle Biju ,  Timothy A. Cernak ,  Yongqi Deng ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Joseph Kozlowski ,  Derun Li ,  Guoqing Li ,  Qinglin Pu ,  Zhi-Cai Shi ,  Wensheng Yu ,  Hongjun Zhang

IPC: C07F5/02 ,  C07D271/08 ,  C07D413/12

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10538497B2

公开(公告)日：2020-01-21

申请号：US16061597

申请日：2016-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yongxin Han ,  Abdelghani Achab ,  Purakkattle Biju ,  Yongqi Deng ,  Xavier Fradera ,  Liangqin Guo ,  Shuwen He ,  Joseph Kozlowski ,  Ravi Kurukulasuriya ,  Kun Liu ,  Meredeth Ann McGowan ,  Qinglin Pu ,  Nunzio Sciammetta ,  Hongjun Zhang ,  Hua Zhou

IPC: A61K31/4245 ,  A61K31/433 ,  C07D271/08 ,  C07D285/10 ,  C07D413/12 ,  C07D417/12 ,  A61P35/00 ,  A61P31/12 ,  A61P25/24 ,  A61P25/28 ,  A61P37/06 ,  A61P27/12 ,  A61P31/14 ,  A61P35/02

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20150361101A1

公开(公告)日：2015-12-17

申请号：US14766462

申请日：2014-02-03

Applicant: Xing DAI ,  Anandan PALANI ,  Shuwen HE ,  Linda L. BROCKUNIER ,  Ravi NARGUND ,  Karen MARCANTONO ,  Nicolas Zorn ,  Dong XIAO ,  Xuanjia PENG ,  Tao GUO ,  MERCK SHARP & DOHME CORP.

Inventor： Xing Dai ,  Hong Liu ,  Anandan Palani ,  Shuwen He ,  Linda L. Brockunier ,  Ravi Nargund ,  Karen Marcantonio ,  Nicolas Zorn ,  Dong Xiao ,  Xuanjia Peng ,  Peng Li ,  Tao Guo

IPC: C07D519/00 ,  C07D471/14 ,  A61K31/4375 ,  A61K31/5025 ,  A61K31/438 ,  A61K31/55 ,  C07D471/22 ,  C07D471/04 ,  C07D471/20 ,  A61K45/06 ,  A61K31/519

CPC classification number: C07D519/00 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D471/22 ,  C07D487/14 ,  A61K2300/00

Abstract: The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract translation: 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的用途的式I化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。

公开(公告)号：US11352320B2

公开(公告)日：2022-06-07

申请号：US17057921

申请日：2019-05-28

Applicant: Merck Sharp & Dohme Corp.

Inventor： Shuwen He ,  Dane Clausen ,  Liangqin Guo ,  Yongxin Han ,  Xianhai Huang ,  Alexander Pasternak ,  Qinglin Pu ,  Dong Xiao ,  Li Xiao ,  Feng Ye ,  Hongjun Zhang

IPC: C07C13/06 ,  C07C233/65 ,  C07C233/80 ,  A61K31/166 ,  C07C271/14 ,  A61P35/00 ,  C07D213/74 ,  C07D237/34 ,  C07D239/42 ,  C07D239/94 ,  C07D241/20 ,  C07D471/04 ,  A61K45/06

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11267786B2

公开(公告)日：2022-03-08

申请号：US17057959

申请日：2019-05-28

Applicant: Merck Sharp & Dohme Corp. ,  Shuwen He ,  Yongxin Han ,  Alexander Pasternak

Inventor： Shuwen He ,  Yongxin Han ,  Alexander Pasternak

IPC: C07D215/14 ,  A61K45/06

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20210395240A1

公开(公告)日：2021-12-23

申请号：US17287256

申请日：2019-10-28

Applicant: Dane CLAUSEN ,  Merck Sharp & Dohme Corp.

Inventor： Dane Clausen ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Joseph Kozlowski ,  Guoqing Li ,  Theodore A. Martinot ,  Alexander Pasternak ,  David Sloman ,  Li Xiao ,  Wensheng Yu ,  Rui Zhang

IPC: C07D413/14 ,  C07D401/14

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20210393600A1

公开(公告)日：2021-12-23

申请号：US17047247

申请日：2019-04-15

Applicant: Merck Sharp & Dohme Corp.

Inventor： Liangqin Guo ,  Hongjun Zhang ,  Ping Chen ,  Dane Clausen ,  Xavier Fradera ,  Yongxin Han ,  Shuwen He ,  Xianhai Huang ,  Alexander Pasternak ,  Qinglin Pu ,  Li Xiao ,  Feng Ye

IPC: A61K31/44 ,  A61K45/06 ,  C07C237/22 ,  C07C255/60 ,  C07D213/75 ,  C07C271/36 ,  C07C233/78 ,  C07C271/24 ,  C07C233/79 ,  C07D213/81 ,  C07D271/06 ,  C07D239/28 ,  C07D215/48 ,  C07C275/30 ,  C07C275/28 ,  C07D239/42 ,  C07D305/06 ,  C07D261/08 ,  C07D471/04 ,  C07D261/20 ,  C07D209/34 ,  C07D277/56 ,  C07D217/02 ,  C07D231/14 ,  C07D237/28 ,  C07D241/24 ,  C07D217/26 ,  A61K31/167 ,  A61K31/27 ,  A61K31/4245 ,  A61K31/47 ,  A61K31/17 ,  A61K31/505 ,  A61K31/337 ,  A61K31/437 ,  A61K31/42 ,  A61K31/426 ,  A61K31/472 ,  A61K31/415 ,  A61K31/4965

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.