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公开(公告)号：US20200032312A1
公开(公告)日：2020-01-30
申请号：US16589634
申请日：2019-10-01
发明人： Naveen Bhatnagar , Robin Meccariello , Jonathan C. Lansing , Daniel Ortiz , Hetal Sarvaiya , Nathaniel J. Washburn
摘要： Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
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公开(公告)号：US20180305725A1
公开(公告)日：2018-10-25
申请号：US15954146
申请日：2018-04-16
发明人： Naveen Bhatnagar , Robin Meccariello , Jonathan C. Lansing , Daniel Ortiz , Hetal Sarvaiya , Nathaniel Washburn
CPC分类号： C12P21/005 , C07K16/00 , C07K2317/41 , C07K2317/52 , C12N9/1081 , C12Q1/48 , C12Y204/99001 , C12Y204/99003 , G01N2333/91091 , G01N2440/38
摘要： Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
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公开(公告)号：US20220267460A1
公开(公告)日：2022-08-25
申请号：US17259480
申请日：2019-07-11
发明人： Jonathan C. Lansing , Daniel Ortiz
IPC分类号： C07K16/28
摘要： The present disclosure relates to compositions and methods of engineered Fc-antigen binding domain constructs, where the Fc-antigen binding domain constructs include at least two Fc domains and at least one antigen binding domain.
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公开(公告)号：US11220531B2
公开(公告)日：2022-01-11
申请号：US16474640
申请日：2018-01-05
摘要： The present disclosure relates to engineered IgG Fc constructs and uses thereof.
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公开(公告)号：US20210317227A1
公开(公告)日：2021-10-14
申请号：US17259443
申请日：2019-07-11
IPC分类号： C07K16/28
摘要： The present disclosure relates to compositions and methods of engineered Fc-antigen binding domain constructs, where the Fc-antigen binding domain constructs include at least two Fc domains and at least one antigen binding domain.
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公开(公告)号：US20210284717A1
公开(公告)日：2021-09-16
申请号：US17259051
申请日：2019-07-11
发明人： Jonathan C. Lansing , Daniel Ortiz
摘要： The present disclosure relates to compositions and methods of engineered Fc-antigen binding domain constructs, where the Fc-antigen binding domain constructs include at least two Fc domains and at least one antigen binding domain.
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公开(公告)号：US20210277438A1
公开(公告)日：2021-09-09
申请号：US17100428
申请日：2020-11-20
发明人： Naveen Bhatnagar , Robin Meccariello , Jonathan C. Lansing , Daniel Ortiz , Hetal Sarvaiya , Nathaniel J. Washburn
摘要： Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
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18.发明申请公开(公告)号：US20210147549A1
公开(公告)日：2021-05-20
申请号：US17259067
申请日：2019-07-11
IPC分类号： C07K16/28
摘要： Fc-antigen binding constructs having a PD-L1 binding domain and two or more Fc domains are described as are methods for using such constructs. Also described are polypeptides making up such constructs. Fc domain monomers that are included in the constructs can include amino acid substitutions that promote homodimerization or heterodimerization.
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公开(公告)号：US20240141401A1
公开(公告)日：2024-05-02
申请号：US18217401
申请日：2023-06-30
发明人： Naveen Bhatnagar , Robin Meccariello , Jonathan C. Lansing , Daniel Ortiz , Hetal Sarvaiya , Nathaniel J. Washburn
CPC分类号： C12P21/005 , C07K16/00 , C12N9/1081 , C12Q1/48 , C12Y204/99001 , C12Y204/99003 , C07K2317/41 , C07K2317/52 , G01N2333/91091 , G01N2440/38
摘要： Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.
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公开(公告)号：US20220153833A1
公开(公告)日：2022-05-19
申请号：US16081829
申请日：2017-03-02
发明人： Carlos J. Bosques , James S. Huston , Jonathan C. Lansing , Leona E. Ling , James Meador, III , Daniel Ortiz , Laura Rutitzky , Birgit C. Schultes
IPC分类号： C07K16/28
摘要： The present invention relates to methods of using biologically active Fc domain-containing therapeutic constructs (Fc constructs) to induce immune cell activation of the immune response in a subject, and for example, to treat diseases such as cancers and infections in a subject. Such Fc constructs may include 5 or more Fc domains.
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