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35 条记录 (耗时 0.025 秒)

    Peptides and compositions
    13.
    发明授权
    Peptides and compositions 失效
    肽和组合物

    公开(公告)号：US4816441A

    公开(公告)日：1989-03-28

    申请号：US930481

    申请日：1986-11-14

    申请人： Jesper Zeuthen ,  Lars Thim ,  Niels P. H. Moller

    发明人： Jesper Zeuthen ,  Lars Thim ,  Niels P. H. Moller

    IPC分类号： C12P21/02 ,  A61K35/74 ,  A61K38/00 ,  C07K1/20 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/195 ,  C07K14/31 ,  C07K14/41 ,  C07K14/52 ,  A61K37/02 ,  C07K7/10

    CPC分类号： C07K14/31 ,  A61K38/00

    摘要： Peptides of the formula R.sup.1 -His-Asp-Glu-Ala-R wherein R.sup.1 is Ala-Gln, and R is a polypeptide residue with up to 50 amino acid residues, and wherein one, more or all of the amino acid residues in R.sup.1 and/or R independently may be omitted, can be used to augment cell mediated cytotoxicity and thereby to treat cancers and viral infections. These peptides may be prepared by proteolytic digestion of Staphylococcus aureus protein A, as well as by protein synthesis, recombinant DNA methods or any other methods known in the art.

    摘要翻译： 式R1-His-Asp-Glu-Ala-R的肽，其中R1是Ala-Gln，R是具有至多50个氨基酸残基的多肽残基，并且其中R1中的一个，多个或全部的氨基酸残基 和/或R独立地可以省略，可以用于增加细胞介导的细胞毒性，从而治疗癌症和病毒感染。 这些肽可以通过金黄色葡萄球菌蛋白A的蛋白水解消化，以及通过蛋白质合成，重组DNA方法或本领域已知的任何其它方法来制备。

    Pancreatic spasmolytic polypeptide
    14.
    发明授权
    Pancreatic spasmolytic polypeptide 失效
    胰腺解痉多肽

    公开(公告)号：US4370317A

    公开(公告)日：1983-01-25

    申请号：US241851

    申请日：1981-03-09

    申请人： Klavs H. Jorgensen ,  Karin D. Jorgensen ,  Lars Thim

    发明人： Klavs H. Jorgensen ,  Karin D. Jorgensen ,  Lars Thim

    IPC分类号： A61K38/00 ,  C07K14/575 ,  A61K37/00

    CPC分类号： C07K14/575 ,  A61K38/00

    摘要： The invention relates to a novel purified polypeptide which is recoverable from porcine pancreas glands. The amino acid composition of the said polypeptide has been determined to be as follows:Trp (2), Lys (4), His (1), Arg (5), Asx (10), Thr (3), Ser (9), Glx (12), Pro (12), Gly (6), Ala (6), Cys 1/2 (14), Val (7), Met (2), Ile (3), Leu (1), Try (2), Phe (7), wherein the determinations are subjected to the usual error of .+-.10 percent of the indicated figures. The partial amino acid sequence comprising a total of 45 amino acids from the N-terminal, is believed to be: ##STR1## wherein pyrGlu (residue 1) stands for pyroglutamic acid. The purified polypeptide is of utility as a medicament, for example as a spasmolytic agent, as an agent for treatment of gastroduodenal ulcers and as a diagnostic aid.

    摘要翻译： 本发明涉及可从猪胰腺中回收的新型纯化多肽。 已确定所述多肽的氨基酸组成如下：Trp（2），Lys（4），His（1），Arg（5），Asx（10），Thr（3），Ser（9） ，Glx（12），Pro（12），Gly（6），Ala（6），Cys 1/2（14），Val（7），Met（2），Ile（3） （2），Phe（7），其中所述测定经受所示图的+/- 10％的通常误差。 包含总共45个氨基酸的部分氨基酸序列被认为是：其中pyrGlu（残基1）代表焦谷氨酸。 纯化的多肽可用作药物，例如作为解痉药，作为治疗胃十二指肠溃疡的药剂和诊断辅助剂。

    Mucosal repair by TFF2 peptides
    16.
    发明申请
    Mucosal repair by TFF2 peptides 审中-公开

    公开(公告)号：US20060293221A1

    公开(公告)日：2006-12-28

    申请号：US11349569

    申请日：2006-02-08

    申请人： Lars Thim ,  Steen Poulsen

    发明人： Lars Thim ,  Steen Poulsen

    IPC分类号： A61K38/17

    CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K2319/02

    摘要： The present invention relates to the use of trefoil factor 2 (TFF2) peptides and a pharmaceutical composition comprising TFF2 peptides for increasing the viscosity of mucin in mucus layers and the repair of damaged mucus layers in the gastrointestinal tract (mouth, oesophagus, stomach, small and large intestine, colon) the respiratory passages, the eye, the urinary system (including the bladder) and the cervis uteri.

    Mucosal repair by TFF dimer peptides
    17.
    发明申请
    Mucosal repair by TFF dimer peptides 审中-公开

    公开(公告)号：US20060211605A1

    公开(公告)日：2006-09-21

    申请号：US11439690

    申请日：2006-05-23

    申请人： Lars Thim ,  Steen Poulsen

    发明人： Lars Thim ,  Steen Poulsen

    IPC分类号： A61K38/17

    CPC分类号： A61K38/22 ,  A61K38/1735 ,  A61K2300/00

    摘要： The present invention relates to the use of trefoil factor 1 (TFF1) and trefoil factor 3 (TFF3) dimers and a pharmaceutical composition comprising TFF dimers for increasing the viscosity of mucin in mucus layers and the repair of damaged mucus layers in the gastrointestinal tract (mouth, oesophagus, stomach, small and large intestine, colon) the respiratory passages, the eye, the urinary system (including the bladder) and the cervis uteri.

    Modified .beta..sub.2 -microglobulin
    19.
    发明授权
    Modified .beta..sub.2 -microglobulin 失效
    改良的β2-微球蛋白

    公开(公告)号：US5175113A

    公开(公告)日：1992-12-29

    申请号：US550919

    申请日：1990-03-29

    申请人： Mogens H. Nissen ,  Jesper Zeuthen ,  Flemming S. Larsen ,  Lars Thim ,  Mogens Christensen

    发明人： Mogens H. Nissen ,  Jesper Zeuthen ,  Flemming S. Larsen ,  Lars Thim ,  Mogens Christensen

    IPC分类号： A61K38/00 ,  C07K14/74 ,  C07K16/28 ,  G01N33/68

    CPC分类号： C07K14/70539 ,  C07K16/2833 ,  G01N33/6893 ,  A61K38/00 ,  Y10S436/804

    摘要： Substantially pure modified .beta..sub.2 -microglobulin (m.beta..sub.2 m) of the formula I ##STR1## wherein R.sub.1 is 24-amino acid residue, with the sequence Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-Asn-Gly-Lys-Ser-Asn-Phe-Leu-Asn, R.sub.2 is a 30-amino acid residue with the sequence Tyr-Val-Ser-Gly-Phe-His-Pro-Ser-Asp-Ile-Glu-Val-Asp-Leu-Leu-Lys-Asn-Gly-Glu-Arg-Ile-Gly-Lys-Val-Glu-His-Ser-Asp-Leu-Ser, R.sub.3 is a 20-amino acid residue with the sequence Trp-Ser-Phe-Tyr-Leu-Leu-Tyr-Tyr-Glu-Phe-Thr-Pro-Thr-Glu-Lys-Asp-Glu-Tyr-Ala, R.sub.4 is a 19-amino acid residue with the sequence Arg-Val-Asn-His-Val-Thr-Leu-Ser-Gln-Pro-Lys-Ile-Val-Lys-Trp-Asp-Arg-Asp-Met, X is Phe, Phe-Ser, or Phe-Ser-Lys, and Y is Asp, Lys-Asp, or Ser-Lys-Asp is disclosed. The presence of the protein in body fluids is a diagnostic and/or prognostic marker for the development of a variety of disorders such as different types of cancer and diseases involving the immune system. Also disclosed are specific anti-m.beta..sub.2 m antibodies used for the detection and quantification of m.beta..sub.2 m.

    摘要翻译： 其中R1是24个氨基酸残基的具有Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr序列的基本上纯的经修饰的β2-微球蛋白（mβ2m） -Ser-Arg-His-Pro-Ala-Glu-Asn-Gl y-Lys-Ser-Asn-Phe-Leu-Asn，R2是30-氨基酸残基，具有序列Tyr-Val-Ser-Gly-Phe -His-Pro-Ser-Asp-Ile-Glu-Val-Asp-Leu-Leu-Lys-Asn-Gl y-Glu-Arg-Ile-Gly-Lys-Val-Glu-His-Ser-Asp-Leu- Ser，R3是具有序列Trp-Ser-Phe-Tyr-Leu-Leu-Tyr-Tyr-Glu-Phe-Thr-Pro-Thr-Glu-Lys-Asp-Glu-Tyr- Ala，R4是序列Arg-Val-Asn-His-Val-Thr-Leu-Ser-Gln-Pro-Lys-Ile-Val-Lys-Trp-Asp-Arg-As p- Met，X是Phe，Phe-Ser或Phe-Ser-Lys，Y是Asp，Lys-Asp或Ser-Lys-Asp。 体液中蛋白质的存在是用于发展各种疾病如诊断和/或预后的标志物，例如不同类型的癌症和涉及免疫系统的疾病。 还公开了用于检测和定量m 2 m的特异性抗-mβ2m抗体。